Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Epigenetic Mechanism through which Protein SirT2 Regulates Cell Cycle Progression and Genomic Stability

Published: Wednesday, March 20, 2013
Last Updated: Wednesday, March 20, 2013
Bookmark and Share
The study of IDIBELL researchers confirms antitumor properties of sirtuin 2.

The group of Chromatin Biology of the IDIBELL, led by Alex Vaquero, studies the role of a family of proteins called sirtuins in response to metabolic and genotoxic stress and their contribution to the development of diseases such as cancer and aging control .
 
In this study conducted in collaboration with the research group of Lourdes Serrano Institute of Human Genetics at Rutgers University in New Jersey (USA) and published  in the journal Genes & Development, researchers describe epigenetic mechanisms whereby one of these proteins, the sirtuin 2 (SIRT2) regulates cell cycle progression and genomic stability.
 
Clinical applications of SIRT2

Recently, sirtuins, particularly SIRT1 and SIRT2, have been linked to neurodegenerative diseases. One of the many factors behind these disorders is oxidative stress and the primary response mechanism of our cells to these conditions is regulated for these proteins.
 
According to Àles Vaquero, "SirT1 seems to have a guard role against this type of stress while SIRT2 would have in many cases the opposite effect. The pharmaceutical industry seeks SIRT2 inhibitor drugs for use against these diseases. "
 
The researcher notes that "for this reason it is important to know the tumor suppressor function of SIRT2, and it should be taken into account if, finally, it is offered as treatment."
 
Control of epigenetic marks

Epigenetic modifications are chemical markers in the genome that result in changes in the expression of genes. One of these brands, the acetylation of the amino acid lysine 16 of histone H4 protein (H4K16Ac), appears to be particularly important in regulating the organization and genome integrity. Thus, alteration of this mark causes genome instability and has been linked directly to cancer.
 
A few years ago, Vaquero showed that SIRT2 regulates the removal of this epigenetic mark just before beginning the process of cell division (mitosis), probably to allow adequate compaction of chromosomes during mitosis.
 
In the study published now Genes & Development, IDIBELL researchers have explored the functional relationship between SIRT2, this epigenetic mark and mitosis, to try to understand the consequences of SIRT2 activity and loss of epigenetic marks H4K16Ac during mitosis and cell cycle in general.
 
Vaquero group found that the deacetylation (eliminating chemical mark) of lysine 16 on histone 4 by SIRT2 promotes the enzyme activity of PR-Set7 whose mission is to deposit another epigenetic mark, methylation, in a position very close to K16, lysine 20 of histone H4 same (H4K20me1). SIRT2 not only regulates the activity of PR-Set7 eliminating H4K16Ac also deacetylating PR-Set7 allowing the expansion of the mark throughout the genome.
 
"These marks" explained Vaquero "are key to the process of DNA replication and repair in the progression of mitosis, and chromatin compaction."
 
"SIRT2 acts as the controlling agent: until conditions are right, it doesn't continue the cell cycle" Vaquero explained. "We found that mice in the absence of SirT2, make mitosis and cell division but accumulates genetic damage and increased levels of genomic instability, so these animals are more likely to develop tumors."
 
"In this job," the researcher said "we have found the mechanism that confirms and explains the antitumor properties of SIRT2 and further linking the role of sirtuins in the control of cell epigenetic memory".


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Keeping Growth in Check
Ribosomal proteins RPL5 and RPL11 play an essential role in normal cell proliferation.
Friday, December 13, 2013
Discovered a Mechanism that Induces Migration of Tumor Cells in Liver Cancer
Coordinated overactivation of TGFb and CXCR4 signaling pathways confer migratory properties to the hepatocellular carcinoma cells.
Wednesday, November 06, 2013
High Levels of RANK Protein Interferes with the Differentiation of Mammary Cells
Levels of this protein increase with age, which could explain the increase in breast cancer risk associated with age.
Wednesday, September 11, 2013
Discovered a Future Therapeutic Target for Lung Cancer Treatment
One of the goals of research in cancer genetics and molecular biology is to get an "on demand" treatment, with maximum effect and minimal toxicity.
Monday, July 22, 2013
Discovered the Role of Noncoding 5S rRNA in Protecting the p53 Tumor Suppressor Gene
Over 50% of tumors are associated with mutations in p53.
Thursday, July 04, 2013
An Epigenetic Change Causes the Block of Antitumor Genes
Healthy cells live in a delicate balance between growth-promoting genes (oncogenes) and those who restrain it (anti-oncogenes or tumor suppressor genes).
Wednesday, June 12, 2013
Identified a Key Protein in Maintaining the Identity of B Lymphocytes
This finding could be useful for the study of blood diseases such as lymphoma and leukemia.
Monday, June 10, 2013
Found in Amish a Genetic Mutation Causing Mental Retardation Very Similar to Angelman Syndrome
It is the first time that associates a mutation in HERC2 with human disease.
Wednesday, March 20, 2013
Octavio Romero, RTICC 2012 Cooperative Research Award in Oncology
Gene and cancer group at IDIBELL reqarded for cancer suppression paper.
Thursday, November 22, 2012
Scientific News
Turning Skin Cells into Heart, Brain Cells
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
Shape Of Tumor May Affect Whether Cells Can Metastasize
Illinois researchers found that the shape of a tumor may play a role in how cancer cells become primed to spread.
MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment
Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Analysis of Dog Genome will Provide Insight into Human Disease
An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies – according to a new study led by The Genome Analysis Centre (TGAC).
New Blood Test for The Earlier Diagnosis of Breast Cancer Spread
Researchers at University of Westminster have confirmed that a new blood test can detect if breast cancer has spread to other parts of the body.
First Gene Therapy Successful Against Human Aging
American woman gets biologically younger after gene therapies.
Targeting an ‘Undruggable’ Cancer Gene
RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers.
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!