Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Identification of Plasma Lipid Biomarkers for Prostate Cancer by Lipidomics and Bioinformatics

Published: Monday, April 08, 2013
Last Updated: Monday, April 08, 2013
Bookmark and Share
This study explores a new approach to seeking biomarkers for prostate cancer and other diseases.

Background:
Lipids have critical functions in cellular energy storage, structure and signaling. Many individual lipid molecules have been associated with the evolution of prostate cancer; however, none of them has been approved to be used as a biomarker. The aim of this study is to identify lipid molecules from hundreds plasma apparent lipid species as biomarkers for diagnosis of prostate cancer.

Methodology/Principal Findings:
Using lipidomics, lipid profiling of 390 individual apparent lipid species was performed on 141 plasma samples from 105 patients with prostate cancer and 36 male controls. High throughput data generated from lipidomics were analyzed using bioinformatic and statistical methods. From 390 apparent lipid species, 35 species were demonstrated to have potential in differentiation of prostate cancer. Within the 35 species, 12 were identified as individual plasma lipid biomarkers for diagnosis of prostate cancer with a sensitivity above 80%, specificity above 50% and accuracy above 80%. Using top 15 of 35 potential biomarkers together increased predictive power dramatically in diagnosis of prostate cancer with a sensitivity of 93.6%, specificity of 90.1% and accuracy of 97.3%. Principal component analysis (PCA) and hierarchical clustering analysis (HCA) demonstrated that patient and control populations were visually separated by identified lipid biomarkers. RandomForest and 10-fold cross validation analyses demonstrated that the identified lipid biomarkers were able to predict unknown populations accurately, and this was not influenced by patient's age and race. Three out of 13 lipid classes, phosphatidylethanolamine (PE), ether-linked phosphatidylethanolamine (ePE) and ether-linked phosphatidylcholine (ePC) could be considered as biomarkers in diagnosis of prostate cancer.

Conclusions/significance:
Using lipidomics and bioinformatic and statistical methods, we have identified a few out of hundreds plasma apparent lipid molecular species as biomarkers for diagnosis of prostate cancer with a high sensitivity, specificity and accuracy.

The article is published online in the journal PLoS ONE and is free to access.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Rapid Sub-attomole MicroRNA Detection on a Portable Microfluidic Chip
Researchers describe two key technologies to solve one of the major issues for point of care testing application.
Thursday, February 06, 2014
Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance
Significant advances have been made in the development of plant-based hepatoprotective drugs mostly because of their lower toxicity.
Tuesday, December 03, 2013
Applications of Metabolomics in Cancer Research
This review focuses on specific areas within cancer and carcinogenesis research on which metabolomics has been brought to bear.
Monday, July 22, 2013
Anti-cancer Drug Discovery and Development: Bcl-2 Family Small Molecule Inhibitors
In this article, researchers from The Pennsylvania University College of Medicine discuss the current status of Bcl-2 family small molecule inhibitors in preclinical and clinical development.
Thursday, January 31, 2013
Remodeling of Central Metabolism in Invasive Breast Cancer Compared to Normal Breast Tissue
Researchers from Charité University Hospital have constructed the first comprehensive metabolic map of breast cancer by GC-TOF analysis of a large cohort of breast cancer and normal tissues.
Friday, September 07, 2012
Using Liposomes as Carriers for Polyphenolic Compounds: The Case of Trans-Resveratrol
In this paper scientists designed and characterized liposome formulations based on rigid bilayers, in order to obtain good compatibility with the rigid aromatic portion of the polyphenol molecular structure.
Tuesday, September 04, 2012
Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease
Researchers have utilized X-ray crystallography to demonstrate how these inhibitors coordinate the two-metal endonuclease active site and engage the active site residues.
Tuesday, August 14, 2012
MALDI Imaging Mass Spectrometry for In Situ Proteomic Analysis of Preneoplastic Lesions in Pancreatic Cancer
Researchers from Technische Universität München have shown MALDI-IMS on sections from endogenous mouse models of PDAC is a valuable approach for proteomic investigations of diseased tissue.
Monday, July 16, 2012
Prediction of Gastric Cancer Metastasis through Urinary Metabolomic Investigation using GC/MS
This aim of this article is to gain new insights into tumor metabolism and to identify possible biomarkers with potential diagnostic values to predict tumor metastasis.
Monday, July 16, 2012
Stabilizing Fanconi Anemia with Antioxidants
Fanconi anemia (FA) is a rare genetic disorder which affects one person in 350,000.
Monday, May 14, 2012
DNA Methylation Analysis of Bone Marrow Cells at Diagnosis of Acute Lymphoblastic Leukemia and at Remission
The aim of this study was to identify genes that display aberrant DNA methylation independently of cytogenetic ALL subtype for further mechanistic studies of ALL.
Monday, April 16, 2012
Differential Diagnosis in Idiopathic Granulomatous Mastitis and Tuberculous Mastitis
The purpose of this study is to develop a new algorithm for the differential diagnosis and treatment of IGM and TM.
Monday, April 16, 2012
Integrated Analyses of microRNAs Demonstrate Their Widespread Influence on Gene Expression in High-Grade Serous Ovarian Carcinoma
The Cancer Genome Atlas (TCGA) Network recently catalogued the molecular aberrations in 487 high-grade serous ovarian cancers. This study surveys the miRNAs, in the context of their predicted gene targets.
Monday, April 16, 2012
Real-Time Visualization and Quantitation of Vascular Permeability In Vivo: Implications for Drug Delivery
This paper presents an integrated method to visualize and quantify the real-time dynamics of dextrans in a shell-less chick chorioallantoic (CAM) model.
Monday, April 16, 2012
Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Nanomolar Potency
This article looks at prediction of cancer drug efficacy in its ultimate user, the human patient and reviews current knowledge followed by illustrative examples that, in the absence of definitive data, provide an empirical perspective.
Friday, April 13, 2012
Scientific News
Fighting Cancer with Sticky Nanoparticles
Treatment that uses bioadhesive nanoparticles drug carriers proved more effective than conventional treatments for certain cancers.
Fighting Plant Pathogens with RNA
Researchers develop strategy that could lead to environmentally friendly fungicide to fight pathogens.
Smart Material Hunts Cancers
Team has created smart material that locates and images cancer or tumour sites in tissue.
Examining mtDNA May Help Identify Unknown Ancestry That Influences Breast Cancer Risk
Researchers studying mtDNA in a group of triple negative breast cancer patients found that 13 percent of participants were unaware of ancestry that could influence their risk of cancer.
Gene Therapy Technique May Help Prevent Cancer Metastasis
Gene-regulating RNA molecules could help treat early-stage breast cancer tumors before they spread.
Enhancing Antibiotics to Defeat Resistant Bacteria
Scientists enhance ability of antibiotics to defeat resistant types of bacteria using molecules called PPMOs
MRI Guidance Aids Stem Cell Delivery
Scientists have delivered stem cells to the brain with unprecedented precision, infusing the cells under real-time MRI guidance.
High-Capacity Nanoparticles
New type of nanoparticle can now have three or more drugs packaged within it, allowing for customised cancer therapy.
UTSW Creates Nanoparticles That Target Lung Cancer Cells
Researchers at UTSW have developed a synthetic polymers that could deliver nucleic acid drugs while possessing enough structural diversity to discover cancer cell-specific nanoparticles.
Delivering Beneficial Bacteria
Method that transports microbes through the stomach to the intestine may benefit human health.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!