Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Gene Signature Can Predict Who Will Survive Chemotherapy

Published: Tuesday, April 16, 2013
Last Updated: Tuesday, April 16, 2013
Bookmark and Share
An eight gene ‘signature’ can predict length of relapse-free survival after chemotherapy, finds new research in Biomed Central’s open access journal BMC Medicine.

Researchers from Academia Sinica and the National Taiwan University College of Medicine first identified genes that were involved in cellular invasion, a property of many cancer cells, using the National Cancer Institute’s 60 human cancer cell line panel (NCI-60). Comparing the pattern of activation of each of these genes in different cell lines with how these cell lines responded to 99 different anti-cancer drugs,  helped narrow down the list of genes to just those which could potentially influence the outcome of chemotherapy.

Testing this link, Prof Ker-Chau Li, from Academia Sinica and UCLA, commented, “Our study found eight genes which were involved in invasion, and the relative activation of these genes correlated to  chemotherapy outcome, including the receptor for growth factor EGF. We also found that some invasion genes had unique patterns of expression that reflect  the differential cell  responses to each of the chemotherapy agents - five drugs (paclitaxel, docetaxel, erlotinib, everolimus and dasatinib) had the greatest effect.”

When the researchers looked at gene expression data of these eight genes from cancer cell lines they found that there was an obvious difference between cells which responded to chemotherapy and those who did not (albeit with some overlap). In clinical studies, looking at lung and breast cancer, the patients, whose gene signature put them in the low-risk group, had a longer relapse free survival than the high-risk group.

Prof Pan-Chyr Yang of National Taiwan University  added, “The discovery of prognostic biomarkers for chemotherapy patients remains critical toward improving the efficacy of cancer treatment. The eight-gene signature obtained here may help choice of treatment as part of individualized cancer therapy and our method of gene discovery may be applicable in studying other cancers.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Imaging Software Could Speed Up Breast Cancer Diagnosis
Researchers use high speed optical microscopy of intact breast tissue specimens to analyze breast tissue.
Friday, August 21, 2015
Leukaemia Drug Could Help Treat Breast Cancer
A drug currently used to treat leukaemia might also help prevent breast cancer from spreading to other parts of the body.
Friday, August 23, 2013
A Possible Blood Test for Alzheimer’s Disease
A new blood test can be used to discriminate between people with Alzheimer's disease and healthy controls.
Monday, July 29, 2013
Oxygen-Free Energy Designed to Fuel Brain Development Spurs on Growth of Cancer
The metabolic process which fuels the growth of many cancers has its origins in normal brain growth finds a new study published in BioMed Central's open access journal Cancer & Metabolism.
Wednesday, January 23, 2013
Genetic Predictor of Breast Cancer Response to Chemotherapy
Gene expression 'signatures' to measure the susceptibility of tumor cells to chemotherapy.
Friday, May 11, 2012
Cellular 'Glue' Resists Breast Cancer
New research demonstrates that the protein Perp provides a potential new target for future treatment of breast cancer.
Thursday, April 19, 2012
DIMming Cancer Growth - STAT: diindolylmethane Suppresses Ovarian Cancer
New research published in BioMed Central’s open access journal BMC Medicine has looked in detail at the action of DIM and showed that it works by blocking the activation and production of the transcription factor STAT3.
Wednesday, January 25, 2012
Relatives of Melanoma Patients Ignore their Skin Cancer Risk
New research shows that young people in ‘at risk’ group are still ignoring sun safety advice.
Thursday, December 29, 2011
Elevated Hormone Levels Add Up to Increased Breast Cancer Risk
New research found that the risk of breast cancer increased with the high levels of estrogen or testosterone hormones.
Monday, October 24, 2011
Modeling Cancer Using Ecological Principles
New research uses Tilman model of competition between invasive species to study the metastasis of prostate cells into bone.
Tuesday, October 04, 2011
Heart Disease Beats Breast Cancer as the Biggest Killer
Research shows that women with breast cancer died from other causes and that over the length of the study cardiovascular disease was the leading cause of death.
Tuesday, June 21, 2011
C-reactive Protein Levels Predict Breast Cancer Survival Rates
BioMed Central's new research shows that elevated CRP levels are predictive of a poor prognosis for breast cancer sufferers.
Friday, June 03, 2011
Coffee Reduces Breast Cancer Risk
Research shows that drinking coffee specifically reduces the risk of antiestrogen-resistant estrogen-receptor (ER)-negative breast cancer.
Wednesday, June 01, 2011
High Throughput RNAi Assay Optimization Using Adherent Cell Cytometry
Researchers from Harvard Medical School have detailed how adherent cell cytometry can be used as a high throughput-screening tool for the optimization of RNAi assays, accelerating in vitro cell assays and reducing costs.
Tuesday, May 03, 2011
Quantitative miRNA Expression Analysis Using Fluidigm Microfluidics Dynamic Arrays
An article published in the journal BMC Genomics demonstrates how the qPCR-array based microfluidic dynamic array platform can be used in conjunction with multiplexed RT reactions for miRNA gene expression profiling.
Tuesday, April 12, 2011
Scientific News
Tolerant Immune System Increases Cancer Risk
Researchers have found that individuals with high immunoCRIT ratios may have an increased risk of developing certain cancers.
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
New Gene Therapy for Vision Loss From a Mitochondrial Disease
NIH-funded study shows success in targeting mitochondrial DNA in mice.
Predictive Model for Breast Cancer Progression
Biomedical engineers have demonstrated a proof-of-principle technique that could give women and their oncologists more personalized information to help them choose options for treating breast cancer.
Specific Variations in RNA Splicing Linked to Breast Cancer
Researchers have identified cellular changes that may play a role in converting normal breast cells into tumors. Targeting these changes could potentially lead to therapies for some forms of breast cancer.
Gene Expression: A Snapshot of Stem Cell Development
New genes found that regulate development of stem cells.
Assessing Cancer Patient Survival and Drug Sensitivity
RNA editing events another way to investigate biomarkers and therapy targets.
Editing Genes to Create HIV Killers
Seattle scientists have managed to genetically transform human cells in the lab from HIV targets to HIV killers, and the technique could have implications for cancer and other diseases.
Researchers Disguise Drugs As Platelets to Target Cancer
Researchers have for the first time developed a technique that coats anticancer drugs in membranes made from a patient’s own platelets.
A New Single-Molecule Tool to Observe Enzymes at Work
A team of scientists at the University of Washington and the biotechnology company Illumina have created an innovative tool to directly detect the delicate, single-molecule interactions between DNA and enzymatic proteins.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos