Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Finding, Fighting the Fat that Fuels Cancer

Published: Monday, May 20, 2013
Last Updated: Monday, May 20, 2013
Bookmark and Share
UT Southwestern research examines role of certain fat cells in tumorigenesis.

Scientists at UT Southwestern Medical Center have made a key observation regarding how fat cells (also referred to as adipocytes) interact with tumor cells and thereby allow a cancer to thrive in dense breast tissue or fatty livers.

Fat cells near tumors secrete a variety of extracellular factors, some of which boost tumor development and progression, the UT Southwestern researchers report in the November issue of the Journal of Clinical Investigation.

The correlation between obesity and various solid and hematological cancers - along with other diseases like diabetes, osteoarthritis, and cardiovascular disease - has long been known.

The ongoing challenge - and the focus of this latest investigation by Dr. Philipp Scherer, Director of the Touchstone Center for Diabetes Research at UT Southwestern - is to identify which extracellular factors are most important in driving tumor growth and to determine how to target them.

The UTSW research has found that endotrophin is a fat cell-derived extracellular factor that fuels the growth of breast tumors in mice.

Working with the lead author, Dr. Jiyoung Park, assistant instructor of internal medicine, Dr. Scherer showed that blocking endotrophin secreted by the rodent’s fat cells had a remarkable effect on breast cancer tumors: blocking endotrophin with an antibody not only reduced tumor growth, but also prevented the cancer from metastasizing to other parts of the body.

“Not all fat is bad, but endotrophin happens to be more abundant in unhealthy fat tissue,” Dr. Scherer said.

“In the context of tumor growth, fat cell-derived endotrophin stimulates the growth of blood vessels that in turn feed cancer cells and enables the tumor to grow more rapidly.
“As we gain weight, we not only have an increased risk of developing cancer, but we also decrease the chance of successfully fighting the tumor,” Dr. Scherer said.

The researchers said future efforts will explore various pathological settings to establish whether this blocking approach is a viable strategy in the clinic.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Researchers Discover Molecule that Accelerates Tissue Regeneration
Newly discovered molecule, SW033291 accelerate cell recovery following bone marrow transplants.
Friday, June 12, 2015
UT Southwestern Faculty Members Named HHMI Investigators
Appointment of Dr. Kim Orth and Dr. Joshua Mendell to HHMI.
Saturday, May 23, 2015
Scientists Identify Key Receptors Behind Development of AML
Blocking ITIM-receptor signaling in combination with conventional therapies may represent a novel strategy for AML treatment.
Saturday, May 02, 2015
Study Reveals Molecular Genetic Mechanisms Driving Breast Cancer Progression
The findings are published online and in the journal Molecular Cell.
Saturday, April 04, 2015
New Cyclotron Facility at UT Southwestern
Expands research opportunities and imaging capabilities for detecting, tracking cancer.
Friday, March 20, 2015
Acetate Supplements Shown to Speed Up Cancer Growth
A major compound produced in the gut by host bacteria.
Friday, February 20, 2015
MAGE Genes Provide Insight into Optimizing Chemotherapy
UT Southwestern Medical Center scientists have identified a new biomarker that could help identify patients who are more likely to respond to certain chemotherapies.
Tuesday, February 17, 2015
Researchers Identify ‘Achilles heel’ in Metabolic Pathway
Achilles heel could lead to new lung cancer treatments.
Saturday, February 14, 2015
Study Links Deficiency of Cellular Housekeeping Gene with Aggressive Forms of Breast Cancer
Research team studies genes involved in the autophagy process and their roles in cancer, aging, infections, and neurodegenerative diseases.
Saturday, January 31, 2015
Targeting The Cell’s ‘Biological Clock’
Researchers target the cell’s ‘biological clock’ in promising new therapy to kill cancer cells, shrink tumor growth.
Monday, January 05, 2015
Whole-Genome Sequencing Successfully Identifies Cancer-Related Mutations
UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients’ risk for hereditary cancer.
Wednesday, December 24, 2014
Scientists Identify New and Beneficial Function of Endogenous Retroviruses
Researchers found that ERV play a critical role in the body’s immune defense against common bacterial and viral pathogens.
Friday, December 19, 2014
Signaling Mechanism Could Be Target For Survival, Growth Of Tumor Cells In Brain Cancer
Non-canonical EGFR signalling shown to make glioblastoma tumor cells more resistant to chemotherapy treatment.
Monday, December 15, 2014
Cancer Researchers Identify Gene Mutations and Process for How Kidney Tumors Develop
Researchers have identified more than 3,000 new mutations by using next generation gene sequencing techniques.
Saturday, November 29, 2014
Study Identifying Cell of Origin for Large, Disfiguring Nerve Tumors
Lays groundwork for development of new therapies.
Wednesday, November 12, 2014
Scientific News
Long Telomeres Associated with Increased Lung Cancer Risk
Genetic predisposition for long telomeres predicts increased lung adenocarcinoma risk.
First Artificial Ribosome Designed
Researchers at the University of Illinois at Chicago and Northwestern University have engineered a tethered ribosome that works nearly as well as the authentic cellular component, or organelle, that produces all the proteins and enzymes within the cell.
Identifying a Key Growth Factor in Cell Proliferation
Researchers discover that aspartate is a limiter of cell proliferation.
A Gene-Sequence Swap Using CRISPR to Cure Haemophilia
For the first time chromosomal defects responsible for hemophilia have been corrected in patient-specific iPSCs using CRISPR-Cas9 nucleases
New Tool Uses 'Drug Spillover' to Match Cancer Patients with Treatments
Researchers have developed a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best "kinase inhibitor" to silence these dangerous genetic causes of disease.
New Material Opens Possibilities for Super-Long-Acting Pills
A pH-responsive polymer gel could create swallow able devices, including capsules for ultra-long drug delivery.
New Tool For Investigating RNA Gone Awry
A new technology – called “Sticky-flares” – developed by nanomedicine experts at Northwestern University offers the first real-time method to track and observe the dynamics of RNA distribution as it is transported inside living cells.
Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support
A new study reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
TOPLESS Plants Provide Clues to Human Molecular Interactions
Scientists at Van Andel Research Institute have revealed an important molecular mechanism in plants that has significant similarities to certain signaling mechanisms in humans, which are closely linked to early embryonic development and to diseases such as cancer.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!