Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researchers Find Unique Peptide with Therapeutic Potential

Published: Thursday, June 13, 2013
Last Updated: Thursday, June 13, 2013
Bookmark and Share
UTSW researchers identify Tat-beclin 1 against cancers, neurological disorders, and infectious diseases.

UT Southwestern Medical Center scientists have synthesized a peptide that shows potential for pharmaceutical development into agents for treating infections, neurodegenerative disorders, and cancer through an ability to induce a cell-recycling process called autophagy.

Autophagy is a fundamental recycling process in which intracellular enzymes digest unneeded and broken parts of the cell into their individual building blocks, which are then reassembled into new parts.

The role of autophagy is crucial both in keeping cells healthy and in enabling them to fight different diseases. Physician scientists in UT Southwestern’s Center for Autophagy Research are deciphering how to manipulate the autophagy process in an effort to disrupt the progression of disease and promote health.

In their latest findings reported online in the journal Nature, Center researchers were able to synthesize a peptide called Tat-beclin 1, which induces the autophagy process.

Mice treated with Tat-beclin-1 were resistant to several infectious diseases, including West Nile virus and another mosquito-borne virus called chikungunya that is common to Asia, Africa, and India.

In additional experiments, the team demonstrated that human cells treated with the peptide were resistant to HIV infection in a laboratory setting.

“Because autophagy plays such a crucial role in regulating disease, autophagy-inducing agents such as the Tat–beclin 1 peptide may have potential for pharmaceutical development and the subsequent prevention and treatment of a broad range of human diseases,” said Dr. Beth Levine, Director of the Center for Autophagy Research and senior author of the study.

Dr. Levine, Professor of Internal Medicine and Microbiology, is a Howard Hughes Medical Institute investigator at UT Southwestern.

Disruption of the autophagy process is implicated in a wide variety of conditions including aging, and diseases, including cancers, neurodegenerative diseases such as Parkinson’s and Alzheimer’s, and infectious diseases such as those caused by West Nile and HIV viruses.

UT Southwestern has applied for a patent on Tat-beclin-1. Peptides are strings of amino acids found in proteins. The Tat-beclin 1 peptide was derived from sequences in beclin 1, one of the first known proteins in mammals found to be essential for autophagy, a finding that was made by Dr. Levine’s laboratory.

Her research has since demonstrated that defects in beclin 1 contribute to many types of disease. Conversely, beclin 1 activity and the autophagy pathway appear to be important for protection against breast, lung, and ovarian cancers, as well as for fighting off viral and bacterial infections, and for protecting individuals from neurodegenerative diseases and aging.

The study was supported by grants from the National Institutes of Health, the National Science Foundation, the HHMI, the Netherlands Organization for Scientific Research-Earth and Life Sciences Open Program, Cancer Research United Kingdom, and a Robert A. Welch Foundation Award.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Enzyme Link Between Excessive Heart Muscle Growth, Cancer Growth
Researchers at UTSW have found that the drugs currently used to inhibit these enzymes in cancer may also be effective in treating enlargement of the heart muscle.
Saturday, April 16, 2016
Treatment of Common Prostate Cancer
Researchers at UTSW have found that the prostate cancer treatments suppress immune response and may promote relapse.
Friday, April 08, 2016
A Metabolic Twist that Drives Cancer Survival
A novel metabolic pathway that helps cancer cells thrive in conditions that are lethal to normal cells has been identified.
Friday, April 08, 2016
Novel Metabolic Twist that Drives Cancer Survival
Researchers at CRI at UT Southwestern have identified a novel metabolic pathway that helps cancer cells thrive in conditions that are lethal to normal cells.
Thursday, April 07, 2016
Structure of Crucial Enzyme Identified
Researchers at UTSW have determined the atomic structure of an enzyme that plays an essential role in cell division and better treatment of cancer.
Thursday, March 31, 2016
Promoting Liver Tissue Regeneration
Researchers at CRI have reported that inactivating a certain protein-coding gene promotes liver tissue regeneration in mammals.
Saturday, March 26, 2016
Researchers Find New Cytoplasmic Role
Researchers at UT Southwestern Medical Center have found new cytoplasmic role for proteins linked to neurological diseases, cancers.
Friday, March 18, 2016
Researchers’ Work Shines LIGHT on how to Improve Cancer Immunotherapy
Researchers at UT Southwestern Medical Center have reported a strategy to make a major advancement in cancer treatment.
Thursday, March 17, 2016
CRI Develops Innovative Approach for Identifying Lung Cancer
Institute has developed innovative approach for identifying processes that fuel tumor growth in lung cancer patients.
Tuesday, February 09, 2016
UT Southwestern Scientists Synthesize Nanoparticles
Synthetic nanoparticles to deliver tumor-suppressing therapies to damaged livers.
Wednesday, January 27, 2016
Tumor-suppressing Gene Works by Restraining Mobile Genetic Elements
Findings from the study leads to new ways of diagnosing and treating cancer.
Saturday, January 23, 2016
UTSW Researchers Identifies How Drugs Alter Pancreatic Cancer Cells
The findings were published in Cell Reports.
Friday, January 22, 2016
Researchers Find a Small Protein that Plays a Big Role in Heart Muscle Contraction
New protein, DWORF, stimulates a calcium-ion pump that controls muscle contraction.
Friday, January 15, 2016
UT Southwestern Scientists Discover a New Role for RNA
Safeguarding chromosome number in human cells, with implications for cancer biology.
Wednesday, December 30, 2015
UT Southwestern Scientist Honored as Rising Star in Texas Research
Dr. Joshua Mendell selected as the recipient of the 2016 Edith and Peter O’Donnell Award in Medicine.
Saturday, December 12, 2015
Scientific News
Turning Skin Cells into Heart, Brain Cells
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.
Detection of HPV in First-Void Urine
Similar sensitivity of HPV test on first void urine sample compared to cervical smear.
Potential “Good Fat” Biomarker
New method to measure the activity of energy consuming brown fat cells could ease the testing weight loss drugs.
Shape Of Tumor May Affect Whether Cells Can Metastasize
Illinois researchers found that the shape of a tumor may play a role in how cancer cells become primed to spread.
MicroRNA Pathway Could Lead to New Avenues for Leukemia Treatment
Cancer researchers at the University of Cincinnati have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Analysis of Dog Genome will Provide Insight into Human Disease
An important model in studying human disease, the non-coding RNA of the canine genome is an essential starting point for evolutionary and biomedical studies – according to a new study led by The Genome Analysis Centre (TGAC).
New Blood Test for The Earlier Diagnosis of Breast Cancer Spread
Researchers at University of Westminster have confirmed that a new blood test can detect if breast cancer has spread to other parts of the body.
First Gene Therapy Successful Against Human Aging
American woman gets biologically younger after gene therapies.
Targeting an ‘Undruggable’ Cancer Gene
RAS genes are mutated in more than 30 percent of human cancers and represent one of the most sought-after cancer targets for drug developers.
Altered Metabolism of Four Compounds Drives Glioblastoma Growth
Findings suggest new ways to treat the malignancy, slow its progression and reveal its extent more precisely.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!