Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Plexpress Launches Dedicated Canine ADME-Tox Service

Published: Friday, July 05, 2013
Last Updated: Friday, July 05, 2013
Bookmark and Share
TRACPACK DOG INDUCTION for preclinical drug candidate screening.

Plexpress has launched a specific ADME-Tox service for canine preclinical drug candidate screening, in collaboration with Admescope.

The new TRACPACK DOG INDUCTION screening service provides canine cytochrome P450 (CYP) mRNA analysis using primary dog hepatocytes followed by CYP enzyme activity measurements.

Hepatocytes from three separate donors are used, generating CYP mRNA expression and protein activity data produced in line with the FDA recommendations for human hepatocytes.

Reliable canine-specific CYP analysis is important in order to improve predictions for human pharmaceutical development.

The validated Dog ADME-Tox mRNA panel from Plexpress includes all relevant CYP targets and reference genes, ready-to-analyze in a single well for high throughput multiplexing.

Additional genes can also be included according to study needs.

The combination of high sample throughput with gene multiplexing increases assay speed while minimizing technical variation, making TRAC highly cost- and time-efficient, boosting efficiency in CRO and Pharma laboratories.

In addition to mRNA analysis, TRACKPACK DOG INDUCTION also offers subsequent CYP activity measurements thanks to Plexpress’ collaboration with Admescope.

To investigate metabolites, study compounds are exposed for 72h, after which substrates for CYP-specific model reactions are added, and the samples analyzed.

TRACPACK DOG INDUCTION provides a single, integrated service for all canine CYP induction analysis, ensuring consistent and reliable data.

All TRACPACK results are delivered electronically, in an easy-to-use, summarized report for quick and easy data analysis.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Plexpress Announces ADME-Tox Programs for CRO’s
EMA and FDA recommend mRNA testing in ADME-Tox studies for superior sensitivity.
Friday, May 03, 2013
Scientific News
Microscopic Fish are 3D-Printed to do More Than Swim
Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
New Strategy for Combating Adenoviruses
Using an animal model they developed, Saint Louis University and Utah State university researchers have identified a strategy that could keep a common group of viruses called adenoviruses from replicating and causing sickness in humans.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Imaging Software Could Speed Up Breast Cancer Diagnosis
Researchers use high speed optical microscopy of intact breast tissue specimens to analyze breast tissue.
A Metabolic Master Switch Underlying Human Obesity
Researchers find pathway that controls metabolism by prompting fat cells to store or burn fat.
Synthetic DNA Vaccine Against MERS Shows Promise
A novel synthetic DNA vaccine can, for the first time, induce protective immunity against the Middle East Respiratory Syndrome (MERS) coronavirus in animal species.
How Small RNA Helps Form Memories
In a new study, a team of scientists at Scripps Florida has found that a type of genetic material called "microRNA" (miRNA) plays surprisingly different roles in the formation of memory in animal models.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!