Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

New Study Changes View about the Genetics of Leukemia Risk

Published: Tuesday, October 15, 2013
Last Updated: Tuesday, October 15, 2013
Bookmark and Share
A gene that helps keep blood free of cancer is controlled by tiny pieces of RNA, a finding that may lead to better ways to diagnose blood cancers.

In the past few years researchers have identified the crucial role of the gene TET2 in keeping blood cells healthy. Mutations of the gene have been found in about 20% of leukemias and indicate a poor prognosis for patients. However, the gene was thought to be irrelevant in 80% of leukemia cases.

The new study changes this view. The researchers identified the agents that could be responsible for many leukemias without TET2 mutation — a host of microRNAs from the large expanse of DNA that do not code for proteins. They found that patients with large numbers of these microRNAs are more likely to have impaired TET2 function, even without a known mutation, and are thus likely to have aggressive forms of cancer.

This knowledge could help doctors develop a course of treatment for leukemia patients, said Jun Lu, assistant professor of genetics, researcher in the Yale Stem Cell Center and Yale Cancer Center, and senior author of the paper.

Lu points out that half of leukemia patients who lack these markers may be spared side effects of aggressive treatments.

“If these markers are absent and TET2 gene is not mutated, then the 50% of leukemia patients without this marker would be spared harsher treatment such as high-dose chemotherapy or bone marrow transplants,” Lu said.

New therapies that could block these microRNAs could in theory help treat blood cancers, he said.

“However, there is currently no good way to do that, but it is a problem I am very hopeful will be resolved,” Lu said.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
Tuesday, February 17, 2015
Yale Team Identifies Key Process In Brain Development
miR-107 shown to play essential role in regulating normal brain development.
Friday, February 06, 2015
Healthy Brain Development Balanced on Edge of a Cellular ‘Sword’
The study helps explain the molecular basis of complex brain abnormalities.
Wednesday, December 24, 2014
New Class of Synthetic Molecules Mimics Antibodies
A Yale University lab has crafted the first synthetic molecules that have both the targeting and response functions of antibodies.
Wednesday, December 24, 2014
Reversing The Effects Of Pulmonary Fibrosis
Study shows potential for reversing the effects of pulmonary fibrosis with a microRNA mimic.
Wednesday, September 24, 2014
Immune Cells get Cancer-Fighting Boost From Nanomaterials
Yale researchers used bundled carbon nanotubes to incubate cytotoxic T cells.
Monday, August 18, 2014
Awakening Genes that Suppress Tumors
When genes that normally suppress tumor growth are themselves suppressed, cancer cells can grow and proliferate uncontrollably.
Tuesday, October 15, 2013
Analysis of Little-Explored Regions of Genome Reveals Dozens of Cancer Triggers
A massive data analysis of natural genetic variants in humans and variants in cancer tumors has implicated dozens of mutations in the development of breast and prostate cancer.
Friday, October 04, 2013
Detecting Breast Cancer: 3-D Screening Reduces Recall Rates
Tomosynthesis, or 3-D mammography, significantly reduced the number of patients being recalled for additional testing after receiving a mammogram.
Tuesday, July 30, 2013
Surprising Mechanism Discovered in Polycystic Kidney Disease
A study has uncovered a new and unexpected molecular mechanism in the development of polycystic kidney disease, or PKD.
Monday, July 29, 2013
Metastatic Tumor a Hybrid of Cancer Cell and White Blood Cell
Scientists have found evidence that a human metastatic tumor can arise when a leukocyte and a cancer cell fuse to form a genetic hybrid.
Monday, July 08, 2013
Brain-Penetrating Particle Attacks Deadly Tumors
Researchers have shown that a new approach extends the lives of laboratory animals and are preparing to seek government approval for a human clinical trial.
Wednesday, July 03, 2013
Promising Drug Prevents Cancer Cells from Shutting Down Immune System
An investigational drug that targets the immune system’s ability to fight cancer is showing promising results in Yale Cancer Center (YCC) patients.
Monday, June 10, 2013
Combined Immunotherapy Shows Promising Results Against Advanced Melanoma
Combining two cancer immunotherapy drugs in patients with advanced melanoma produced rates of tumor regression that appeared greater than in prior trials with either drug alone.
Monday, June 10, 2013
Combined Immunotherapy Shows Promising Results Against Advanced Melanoma
Tumor regression rates are produced by combining two cancer immunotherapy drugs.
Wednesday, June 05, 2013
Scientific News
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Nanocarriers May Carry New Hope for Brain Cancer Therapy
Berkeley lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier.
RNA-Based Drugs Give More Control Over Gene Editing
CRISPR/Cas9 gene editing technique can be transiently activated and inactivated using RNA-based drugs, giving researchers more precise control in correcting and inactivating genes.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
Dead Bacteria to Kill Colorectal Cancer
Scientists from Nanyang Technological University (NTU Singapore) have successfully used dead bacteria to kill colorectal cancer cells.
CRISPR-Cas9 Gene Editing: Check Three Times, Cut Once
Two new studies from UC Berkeley should give scientists who use CRISPR-Cas9 for genome engineering greater confidence that they won’t inadvertently edit the wrong DNA.
Genetically Engineering Algae to Kill Cancer Cells
New interdisciplinary research has revealed the frontline role tiny algae could play in the battle against cancer, through the innovative use of nanotechnology.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos