Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

MiRacle Consortium Receives a € 1.2 Million FP7 Grant from the European Union

Published: Monday, November 04, 2013
Last Updated: Monday, November 04, 2013
Bookmark and Share
Therapeutic development of cancer cell-specific targeting of novel tumor-selective lethal miRNAs for the treatment of head and neck cancer – acronym: MiRacle.

InteRNA Technologies B.V. and VU University Medical Center (VUmc) announce today they have been granted funding from the European Union’s FP7program “Research for the benefit of SMEs”. InteRNA and VUmc, who are leading this consortium, together with Quiet Therapeutics Ltd (Israel), a biopharma SME engaged in the development of a new class of highly selective targeted therapeutics for oncology and inflammation, have been granted around € 1.2 million, to develop the targeted delivery of novel tumor-selective lethal miRNAs for the treatment of head and neck cancer. The consortium further includes BioSpring (Germany), OctoPlus (the Netherlands) and the Laboratory of Pharmacology and Toxicology LPT (Germany).

MiRacle focuses on the development of a targeted therapeutic formulation for the treatment of head and neck cancer. Head and neck (H&N) cancer is the sixth most common cancer worldwide and the incidence increases. Unfortunately the majority of H&N cancer patients present with advanced stages of disease. These patients frequently develop locoregional recurrences, distant metastasis and/or second primary tumors resulting in 5-years survival rates of less than 60% The development of novel anti-cancer agents to improve outcome is therefore urgently awaited.

The goal of MiRacle is the advancement of the safe, targeted delivery of therapeutic tumor-selective lethal miRNA formulation towards the clinic by combining two innovative technologies, i.e. application of therapeutic miRNAs using cancer cell-specific targeted drug delivery.

Besides the expertise on the therapeutic application of miRNA and the in depth knowledge of the therapeutic indication, e.g. H&N cancer, the MiRacle consortium brings together the knowledge on the synthesis of biochemical active miRNAs, the expertise in drug formulation to specifically deliver therapeutic miRNA into humans, the understanding for synthesis of complex drug formulations, the preclinical testing, and the skillfulness in toxicity tests that are required for RNA based drug registration.

 “The unique tumor-selective lethal miRNAs identified display a very interesting biology and potential therapeutic effect that warrants further development towards the clinic. This FP7 grant exemplifies that with this consortium we have all the expertise in place to bring a tumor killing miRNA in a targeted and safe manner towards registration for first in human testing”, said Roel Schaapveld, Chief Executive Officer of InteRNA Technologies.

“This FP7 grant enables the next step in the translation of the tumor-selective lethal microRNAs that we discovered” said Ruud Brakenhof, Professor of Cancer Genetics, Tumor Biology Section at the Department of Otolaryngology/Head-Neck Surgery of VUmc.

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,200+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

InteRNA Technologies Secures Final Extension Series A Financing
Company has announced Hans Schikan as new chairman of its Supervisory Board.
Saturday, October 31, 2015
InteRNA Technologies, UCB and University of Bonn to Collaborate
Agreement on the role of microRNAs in neurodegenerative disease.
Friday, January 10, 2014
InteRNA Technologies Announces Closing of Equity Financing Round
Company secures additional equity financing to progress lead program for melanoma treatment.
Friday, September 06, 2013
InteRNA Technologies Receives Notice of Allowance from USPTO
Patent covers the precursor and mature sequences of miRNA-3157, the Company's lead product in its B-Raf/melanoma program.
Tuesday, October 16, 2012
InteRNA Technologies Receives Notice of Allowance for miRNA Sequences of its Lead Pre-Clinical Product
Patent covers the precursor and mature sequences of miRNA-3157, the Company's lead product in its B-Raf/melanoma program.
Monday, October 15, 2012
Scientific News
Unravelling the Role of Key Genes and DNA Methylation in Blood Cell Malignancies
Researchers from the University of Nebraska Medical Center have demonstrated the role of Dnmt3a in safeguarding normal haematopoiesis.
50-Year-Old Bacteria Could Be Alternative Treatment Option for Cancer
Researchers have developed a non-toxic strain of Salmonella to penetrate and target cancer cells.
Promising Blood Test Fails to Yield Clues About Best Strategies for Bladder Cancer Treatment
Penn Medicine research challenges previous findings on utility of neutrophil-to-lymphocyte ratio as a biomarker.
Fighting Cancer with the Power of Immunity
Researchers at MIT have used a combination of four different therapies to activate both of the immune system’s two branches, producing a coordinated attack that led to the complete disappearance of large, aggressive tumors in mice.
Influential Cancer Researcher Receives Agilent Thought Leader Award
Biologist Scott Lowe receives award in recognition for his contributions to cancer biology.
Gene-Editing Cures Genetic Blood Disorder in Mice
New technology may offer minimally invasive treatment for genetic disorders of the blood.
New Compound Shows Promise in Treating Multiple Human Cancers
The research presents a new way to efficiently kill these cancerous cells and holds promise for the treatment of all cancers.
ALS Study Reveals Role of RNA-Binding Proteins
The findings are a significant step forward in validating RNA-based therapy as a treatment for ALS.
IU Research Reveals Link between Molecular Mechanisms in Prostate Cancer and Ewing's sarcoma
Researchers at IU have suggested that the molecular mechanism that triggers the rare disease Ewing's sarcoma could act as a potential new direction for the treatment of more than half of patients with prostate cancer.
Nanomedicine Aims to Improve HIV Drug Therapies
New research aims to improve the administration and availability of drug therapies to HIV patients using nanotechnology.

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos