Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

VolitionRx Expands Sample Size to 11,000 in Pivotal Colorectal Cancer Trial

Published: Friday, November 15, 2013
Last Updated: Friday, November 15, 2013
Bookmark and Share
Sample collection for the study is due to commence in April 2014 and be completed by the end of 2015.

VolitionRx Limited has announced an increase of 55% (from 6,000 to 11,000) in the number of prospective blood samples to be included in its forthcoming colorectal cancer clinical trial at no additional cost beyond the $1.85 million already announced.

The randomized, blinded study is designed to evaluate the validity of VolitionRx’s proprietary NuQ® panel as a first-step screening tool for colorectal cancer.

Sample collection for this prospective study, which is jointly sponsored by VolitionRx and the University of Copenhagen, is due to commence in April 2014 and be completed by the end of 2015.

With the additional blood samples, 8,000 individuals receiving a positive faecal immunological testing (FIT) result and 3,000 individuals receiving a negative FIT result as part of the Danish national screening programme will now be tested using Volition’s NuQ assay panel.

The results will be verified by colonoscopy. Notably, the Danish team is collecting up to 120 data points for each individual included in the trial (e.g. age, gender, other diseases). This will provide an extremely powerful tool in understanding how different diseases and conditions interrelate with colorectal cancer.

The additional blood samples will be collected by Professor Hans Jørgen Nielsen, Professor of Surgical Oncology at the Department of Surgical Gastroenterology at Hvidovre Hospital, part of the University of Copenhagen, and collaborators at 7 additional Danish hospital departments.

Speaking about the expansion, Professor Nielsen says: “Our decision to provide Volition with these extra samples was driven by the promising interim data from other NuQ trials. This expansion is significant as we will be able to make even stronger conclusions about both the accuracy of VolitionRx’s NuQ blood test and the risk factors of colorectal cancer. We also now have the possibility to re-confirm the results of symptom-free individuals who are undergoing screening.”

Dr Jake Micallef, Chief Scientific Officer of VolitionRx, adds: “Professor Nielsen and collaborators' collection of extensive blood samples provides the opportunity to identify and validate other molecules and genetic components associated with the growth, invasion and dissemination processes of colorectal cancer. We will now have further data to analyze in relation to colonoscopy findings, to demonstrate the performance of a simple NuQ blood test to diagnose colorectal cancer at an early stage in a non-invasive way. The 11,000 prospective samples are in addition to the already collected 4,800 retrospective symptomatic samples for a combined 16,000 individuals. We have received the first 1,000 samples from the retrospective trial we are carrying out in conjunction with Hvidovre Hospital, and will begin the analysis this year.”

In addition to analyzing the 16,000 Danish individuals, Volition is carrying out the following trials:
• 3 ongoing multi-cancer studies at University Hospital in Bonn, Germany, including an 800 patient retrospective study and a 2,000 patient prospective study that involves patients with the 20 most prevalent cancers
• a 250 patient study into colorectal cancer at CHU-UCL Mont Godinne Hospital, Belgium.

Data from these trials will be used to apply for a CE mark for a colorectal cancer test, and will also be submitted to the FDA.

Colorectal cancer is the third most prevalent cancer worldwide, after lung and breast cancers, with approximately 1.24 million new cases diagnosed each year. In the United States alone, 136,717 people were diagnosed with colorectal cancer in 2009, with 51,848 dying from the disease that year.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Potential of New Insect Control Traits in Agriculture
Researchers have discovered a protein that shows promise as an alternate corn rootworm control mechanism.
Fighting Cancer with Sticky Nanoparticles
Treatment that uses bioadhesive nanoparticles drug carriers proved more effective than conventional treatments for certain cancers.
Fighting Plant Pathogens with RNA
Researchers develop strategy that could lead to environmentally friendly fungicide to fight pathogens.
Smart Material Hunts Cancers
Team has created smart material that locates and images cancer or tumour sites in tissue.
Examining mtDNA May Help Identify Unknown Ancestry That Influences Breast Cancer Risk
Researchers studying mtDNA in a group of triple negative breast cancer patients found that 13 percent of participants were unaware of ancestry that could influence their risk of cancer.
Gene Therapy Technique May Help Prevent Cancer Metastasis
Gene-regulating RNA molecules could help treat early-stage breast cancer tumors before they spread.
Enhancing Antibiotics to Defeat Resistant Bacteria
Scientists enhance ability of antibiotics to defeat resistant types of bacteria using molecules called PPMOs
MRI Guidance Aids Stem Cell Delivery
Scientists have delivered stem cells to the brain with unprecedented precision, infusing the cells under real-time MRI guidance.
High-Capacity Nanoparticles
New type of nanoparticle can now have three or more drugs packaged within it, allowing for customised cancer therapy.
UTSW Creates Nanoparticles That Target Lung Cancer Cells
Researchers at UTSW have developed a synthetic polymers that could deliver nucleic acid drugs while possessing enough structural diversity to discover cancer cell-specific nanoparticles.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!