Corporate Banner
Satellite Banner
RNAi
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Route to Boost Pancreatic Cancer Treatment

Published: Monday, June 02, 2014
Last Updated: Monday, June 02, 2014
Bookmark and Share
Cancer Research UK scientists have uncovered new insights into how the key pancreatic cancer drug gemcitabine is broken down in tumour cells.

The scientists, based at the Cancer Research UK Cambridge Institute, have discovered that gemcitabine interacts with an important pathway in cells – called the Kennedy Pathway – which cells use to make special fats.

This research has identified that the drug is broken down in tumour cells by enzymes in the Kennedy Pathway, which might be an alternative way in which it works. 

The findings also suggest that using linoleic acid in combination with gemcitabine increases the amount of gemcitabine in tumour cells, possibly making it more effective.

Study author, Professor Duncan Jodrell, group leader at the Cancer Research UK Cambridge Institute, said: “Gemcitabine is one of the drugs that we use commonly to treat pancreatic cancer, but the number of patients who benefit from it is still relatively small.”

“Improving our understanding of how gemcitabine interacts with cellular metabolism may allow us to develop combination treatments that improve outcomes for patients with pancreatic cancer.”

Around 8,800 people are diagnosed with pancreatic cancer in the UK every year but progress has been slow, with only around three per cent of people surviving their disease five years or more.

Nell Barrie, Cancer Research UK’s senior science communications officer, said: “Sadly, survival from pancreatic cancer is still low and we must do everything we can to fight this challenging disease with better treatments and ways to diagnose it early, when treatment is more effective.

“We’re making progress but it needs to be much faster, which is why Cancer Research UK is prioritising research into pancreatic cancer to save more lives from the disease.”

The research is published in the British Journal of Cancer (BJC).


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Genetic Chaos in Tumours Could Help Predict Chemo Response
Researchers have shown how the level of genetic chaos in tumours could help predict patients’ response to chemotherapy according to new research.
Friday, August 07, 2015
Childhood Cancer Cells Drain Immune System’s Batteries
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body’s immune cells, leaving them too physically drained to fight the disease.
Tuesday, August 04, 2015
‘Liquid Biopsies’ Could Help Spot Genetic Faults in Lung Cancer
Study analyze blood samples from 97 patients who took part in the EURTAC clinical trial.
Saturday, March 07, 2015
New Companies Join Cancer Research UK Consortium
Three new biomarker companies have been selected to work with the Early Diagnosis Consortium, a collaboration between Cancer Research UK, its commercial arm, Cancer Research Technology and Abcodia.
Thursday, December 11, 2014
Why Bowel Cancer Sometimes Outsmarts Treatment
New study challenges the prevailing view of how bowel cancer develops in the large intestine.
Tuesday, December 02, 2014
Cancer Cell Fingerprints in the Blood May Speed up Childhood Cancer Diagnosis
Researchers found unique molecular fingerprints for 11 types of children’s tumours, to develop blood tests to diagnose these cancers.
Tuesday, November 04, 2014
Cancer Research UK, Cancer Research Technology And Asterias Biotherapeutics Partner
Partnership Developed to Trial Immunotherapy Vaccine For Lung Cancer
Friday, September 12, 2014
Cancer Research UK, Astellas Partner on Cancer Treatments
The new collaboration will conduct a two-year research programme in the UK to find promising new drug targets for pancreatic cancer.
Friday, August 08, 2014
Cancer Research UK, AZ and Pfizer Partner to Advance Lung Cancer Treatment
Partnership creates a pioneering clinical trial for patients with advanced lung cancer, marking a new era of research into personalised medicines to treat cancer.
Thursday, April 17, 2014
Final Results from the Phase III TeloVac Trial in Pancreatic Cancer
Results from the trial showed no significant difference in overall survival between the groups that received the vaccine and the control group receiving chemotherapy.
Tuesday, June 04, 2013
Astronomy Algorithms Help Diagnose Aggressive Tumors
Scientists have honed techniques originally developed to spot distant galaxies and used them to identify biomarkers that signal a cancer’s aggressiveness among some 2,000 breast tumours.
Monday, February 25, 2013
Study Points to Potential New Treatment for Deadly Pancreatic Cancer
Cancer Research UK-funded scientists have shown how a promising new class of drugs might be used to treat aggressive forms of pancreatic cancer, according to a study published in Nature.
Tuesday, May 01, 2012
Scientists Find New Drug Target for Hard-to-Treat Leukaemia
Cancer Research UK scientists have discovered a promising new approach to treat a type of myeloid leukaemia – a cancer with limited treatment options and relatively poor survival.
Friday, March 30, 2012
Scientific News
Microscopic Fish are 3D-Printed to do More Than Swim
Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Reprogramming Cancer Cells
Researchers on Mayo Clinic’s Florida campus have discovered a way to potentially reprogram cancer cells back to normalcy.
New Strategy for Combating Adenoviruses
Using an animal model they developed, Saint Louis University and Utah State university researchers have identified a strategy that could keep a common group of viruses called adenoviruses from replicating and causing sickness in humans.
Surprising Mechanism Behind Antibiotic-Resistant Bacteria Uncovered
Now, scientists at TSRI have discovered that the important human pathogen Staphylococcus aureus, develops resistance to this drug by “switching on” a previously uncharacterized set of genes.
Fat in the Family?
Study could lead to therapeutics that boost metabolism.
Imaging Software Could Speed Up Breast Cancer Diagnosis
Researchers use high speed optical microscopy of intact breast tissue specimens to analyze breast tissue.
A Metabolic Master Switch Underlying Human Obesity
Researchers find pathway that controls metabolism by prompting fat cells to store or burn fat.
Synthetic DNA Vaccine Against MERS Shows Promise
A novel synthetic DNA vaccine can, for the first time, induce protective immunity against the Middle East Respiratory Syndrome (MERS) coronavirus in animal species.
How Small RNA Helps Form Memories
In a new study, a team of scientists at Scripps Florida has found that a type of genetic material called "microRNA" (miRNA) plays surprisingly different roles in the formation of memory in animal models.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!