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Wednesday, October 01, 2014
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Targeted gene silencing of the MAPK pathway in acute myeloid leukemia cells using RNAi
Mohd Hafiz bin Mohd Rothi and Mohamed Saifulaman bin Mohamed Said

This study explores the potential of multiple gene knockdown in acute myeloid leukemia of pivotal genes controlling the MAPK pathway using RNA interference. Results demonstrate that blocking a major signaling pathway is more complicated than just knocking down the expression of a few genes.

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Neurocognitive correlates of miRNA expression in the CNS of HIV positive subjects with a history of methamphetamine abuse
Erick T Tatro, Stephanie Shumaker, David J Moore, Igor Grant, Cristian L Achim

Methamphetamine (meth) abuse and HIV infection are public health risks that in combination produce a “double epidemic.” MicroRNAs (miRs) were shown to be involved in CNS development, neuronal homeostasis, and brain disease. Past studies linked miR124 and let7-d with cocaine addiction. Our goal was to determine whether miRs were differentially expressed in HIV-infected individuals with a recent history of meth abuse and to identify the neurocognitive correlates.

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mSMRT-qPCR : Robust, Sensitive, Scalable microRNA Quantification

Existing methods for miRNA quantification rely on sequence-dependent probes or chemically modified primers for optimal specificity and often require RNA isolation that is time-consuming labour-intensive and which increase sample variability We have developed a high performance approach for multiplexed detection of mature miRNAs termed modified stem-loop mediated reverse transcription quantitative PCR (mSMRT-qPCR).

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Transfecting Small Molecules, Peptides
Van Q., Atze K., Litzenberger D., Ackerstaff J.T., Strübing Y., Yolcu D., Franke S.,Mobbs K.J. and Kazinski M.

The Nucleofector® Technology enables efficient and reproducible transfection of primary cells and cell lines at throughputs of up to 96 samples per run. Nucleofection® now extends its range of application to deliver small molecules substrates and protein substrates such as peptides, proteins and antibodyconjugates.

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SuperNatural: A Database of Available Natural Compounds
Melanie Füllbeck, Mathias Dunkel and Robert Preissner

The majority of marketed drugs are natural compounds or derivatives thereof. The compounds availability is often unclear. Therefore we have compiled a database of ~50,000 natural compounds. Starting point for in silico screenings are about 2,500 well-known, classified natural compounds or imported molecules. Possible medical applications can be detected and about three million conformers computed to account for the flexibility during usage of the 3D-superposition algorithm.

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MicroRNA let-7b targets Akt-1: possible implication for skeletal muscle atrophy in diabetic rats
Sousa, TA*; Mitsuo, K**; Paula-Gomes, S*; Silva, VAO*; Tragante, V*; Zanon, NM*; Wang M**; Kettelhut, IC*; Natarajan R**; De Lucca, FL*

In diabetic animals there is marked muscle atrophy, but the molecular mechanisms underlying muscle wasting are still unclear. Our in silico analysis and the inverse correlation between let-7b and Akt1 expression in soleus of diabetic animals indicated Akt1 as a potential let-7b target. The assays of luciferase and inhibition of endogenous expression of Akt1 with mimic let-7b were used to validate Akt1 as a direct target of let-7b.

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Microsphere Approach to Gene Silencing
J. M. Cardenas-Maestre, A. Seth, R. M. Sanchez-Martin

The design of a new generation of bio-compatible polymeric particles (by introduction of polycationic chains as terminal groups) that can be employed as transfecting agents.

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Argonaute 1 regulates germ cell division and oocyte determination in Drosophila melanogaster
Mohd Ghows Mohd Azzam and Ji-Long Liu

We find that Ago1 protein is be enriched in the oocytes and also distributed in the cytoplasm of follicle cells. Using mitotic clonal analysis, we analyze multiple ago1 mutant alleles. Here, we find that the oocyte do not form in many mutant clones and they only have 8 nurse cells. These results indicate that the level of Ago1 affects the number of cystoblast divisions and oocyte determination.

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NEW TECHNOLOGIES FOR FFPE SAMPLES: Improved RNA Isolation and novel cDNA priming for qPCR and for universal mRNA amplification
G Krupp1; R Jaggi2; D Englert3, DJ Wilson3, S Laken3, S, ES Quabius4

Improved FFPE RNA isolation, novel TR priming for complete recovery of FFPE mRNA fragments. Differential expression defines Scores for tumor classification: comparing fresh-frozen with FFPE. Novel flow-through Ziplex microarray platform demonstrates MAQC performance level of data obtained with FFPE samples.

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Showing Results 41 - 50 of 146
Scientific News
Chemists Recruit Anthrax to Deliver Cancer Drugs
With some tinkering, a deadly protein becomes an efficient carrier for antibody drugs.
Biologists Find An Early Sign Of Cancer
Patients show boost in certain amino acids years before diagnosis of pancreatic cancer.
Protein ‘Map’ Could Lead to Potent New Cancer Drugs
Findings will help scientists to design drugs that could target NMT enzyme.
New Approach Aims to Silence Cancer ‘Survival Genes’
Scientists at the University of York are working on a promising new approach for tackling colorectal cancer, the second most common cause of cancer-related death.
DNA in ‘Gene Deserts’ Linked with Breast Cancer
Non-coding DNA raised the risk of breast cancer by affecting the activity of key genes.
Inivata Raises £4m to Realize the Potential of ctDNA Analysis
New spin-out from Cancer Research UK launched with funding from Imperial Innovations, Cambridge Innovation Capital and Johnson & Johnson Development Corporation.
Reversing The Effects Of Pulmonary Fibrosis
Study shows potential for reversing the effects of pulmonary fibrosis with a microRNA mimic.
Gene Expression Patterns in Pancreatic CTCs Revealed
Distinct patterns of gene expression in several groups of CTCs were identified, including significant differences from the primary tumor that may contribute to the ability to generate metastases and prove to be targets for improved treatment of the deadly tumor.
Promise for Treatment of Pancreatic Cancer
Ultrasound microbubbles can improve tumor absorption of cancer drugs.
Novel Drug Targeting Leukemia Cells Enters Clinical Trial
Phase 1 human clinical trial to assess the safety and efficacy of a new monoclonal antibody for CLL patients.
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