Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>Videos>This Video


Plate Reader versus High Content RNAi Screens. Who's Right?
Sheffield University

There are few research areas that have expanded as quickly and spectacularly as the field of RNA interference (RNAi). RNAi based research is now maturing into a multi-billion pound industry. The notion that we can systematically switch off every gene in the genome and screen for important biological processes has become both practical and routine. Marrying this technology with High Content Microscopy we are capable of asking important phenotypic questions in a systematic way. The Sheffield RNAi Screening Facility was born from the fundamentals of the initially highly successful Drosophila melanogaster screening platform and now we operate both the Fruit Fly and Human systems. Due to the ability to compare two screens from different organisms for the first time, results will be presented from a high content siRNA screen in a Human cell line, comparing results to previously intensive screens from 3 genome-wide Drosophila screens completed using a plate reader platform. We will present the benefits and difficulties of both cellular platforms. While presenting the results, we will discuss issues such as the complexities of the type of screening approach adopted.

Request more information
Company product page

Scientific News
New Class of RNA Tumor Suppressors Identified
Two short, “housekeeping” RNA molecules block cancer growth by binding to an important cancer-associated protein called KRAS. More than a quarter of all human cancers are missing these RNAs.
Mathematical Model Forecasts the Path of Breast Cancer
Chances of survival depend on which organs breast cancer tumors colonize first.
Exploring the Causes of Cancer
Queen's research to understand the regulation of a cell surface protein involved in cancer.
Nanocarriers May Carry New Hope for Brain Cancer Therapy
Berkeley lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier.
RNA-Based Drugs Give More Control Over Gene Editing
CRISPR/Cas9 gene editing technique can be transiently activated and inactivated using RNA-based drugs, giving researchers more precise control in correcting and inactivating genes.
University of Glasgow Researchers Make An Impact in 60 Seconds
Early-career researchers were invited to submit an engaging, dynamic and compelling 60 second video illuminating an aspect of their research.
Metabolic Profiles Distinguish Early Stage Ovarian Cancer with Unprecedented Accuracy
Studying blood serum compounds of different molecular weights has led scientists to a set of biomarkers that may enable development of a highly accurate screening test for early-stage ovarian cancer.
Dead Bacteria to Kill Colorectal Cancer
Scientists from Nanyang Technological University (NTU Singapore) have successfully used dead bacteria to kill colorectal cancer cells.
CRISPR-Cas9 Gene Editing: Check Three Times, Cut Once
Two new studies from UC Berkeley should give scientists who use CRISPR-Cas9 for genome engineering greater confidence that they won’t inadvertently edit the wrong DNA.
Genetically Engineering Algae to Kill Cancer Cells
New interdisciplinary research has revealed the frontline role tiny algae could play in the battle against cancer, through the innovative use of nanotechnology.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos