Thursday, February 23, 2012
Technology Networks
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 | Crop Biotechnology: Prospects and Opportunities Jeff Newman, Professor, University of Reading, Speaking at Agrigenomics Congress |
 | Current Perspectives in Fragment Based Ligand Discovery Roderick Hubbard, Professor, University of York, speaking at Medchem Europe 2011 |
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
Protein Dynamics at Eph Receptor-Ligand Interfaces as Revealed by Crystallography, NMR and MD Simulations
The research highlights the key role of protein dynamics in Eph-ephrin signalling, demonstrating how this would benefit future design of agonists/antagonists targeting Eph receptors.
Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
Some of the compounds prepared were shown to possess remarkable antibacterial, antifungal and anti-inflammatory activities.
Analyzing and Mapping Sweat Metabolomics by High-Resolution NMR Spectroscopy
Researchers from the Russian Academy of Sciences have utilized high-resolution to NMR to study and identify the content of human sweat.
Noninvasive Detection of Filaggrin Gene Mutations Using Raman Spectroscopy
In this article researchers assess filaggrin content in the skin using Raman spectroscopy, comparing the results to FLG genotyping of Mexican-mestizo patients.
Infrared Spectroscopy and Microscopy in Cancer Research and Diagnosis
This review illustrates some principles of Fourier transform Infrared vibrational spectroscopy and microscopy as a useful method to interrogate molecules in specimen by mid-IR radiation.
Revisiting the NMR Structure of the Ultrafast Downhill Folding Protein gpW from Bacteriophage?
In this study researchers from the Spanish National Research Council have utilised multidimensional NMR to re-determine the high-resolution structure of gpW.
Agilent Technologies Awards 2011 Russell Varian Prize for Innovation in Nuclear Magnetic Resonance
Prize is awarded to a researcher based on a single innovative contribution proven to have a significant impact on state-of-the-art nuclear magnetic resonance (NMR) technology.
Combining Portable Raman Probes with Nanotubes for Theranostic Applications
This study reports the simultaneous detection and irradiation of carbon nanotubes in 2D monolayers of cancer cells and in 3D spheroids using a portable Raman probe.
2011 Russell Varian Prize for Innovation in Nuclear Magnetic Resonance
Agilent Technologies Inc. announces Gareth Alun Morris, professor of physical chemistry at the University of Manchester, as the winner of the 2011 Russell Varian Prize.
Accessing Protein Conformational Ensembles Using Room-Temperature X-Ray Crystallography
This article describes how monitoring room-temperature conformational ensembles by X-ray crystallography can reveal motions crucial for catalysis, ligand binding, and allosteric regulation.
The research highlights the key role of protein dynamics in Eph-ephrin signalling, demonstrating how this would benefit future design of agonists/antagonists targeting Eph receptors.
Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs
Some of the compounds prepared were shown to possess remarkable antibacterial, antifungal and anti-inflammatory activities.
Analyzing and Mapping Sweat Metabolomics by High-Resolution NMR Spectroscopy
Researchers from the Russian Academy of Sciences have utilized high-resolution to NMR to study and identify the content of human sweat.
Noninvasive Detection of Filaggrin Gene Mutations Using Raman Spectroscopy
In this article researchers assess filaggrin content in the skin using Raman spectroscopy, comparing the results to FLG genotyping of Mexican-mestizo patients.
Infrared Spectroscopy and Microscopy in Cancer Research and Diagnosis
This review illustrates some principles of Fourier transform Infrared vibrational spectroscopy and microscopy as a useful method to interrogate molecules in specimen by mid-IR radiation.
Revisiting the NMR Structure of the Ultrafast Downhill Folding Protein gpW from Bacteriophage?
In this study researchers from the Spanish National Research Council have utilised multidimensional NMR to re-determine the high-resolution structure of gpW.
Agilent Technologies Awards 2011 Russell Varian Prize for Innovation in Nuclear Magnetic Resonance
Prize is awarded to a researcher based on a single innovative contribution proven to have a significant impact on state-of-the-art nuclear magnetic resonance (NMR) technology.
Combining Portable Raman Probes with Nanotubes for Theranostic Applications
This study reports the simultaneous detection and irradiation of carbon nanotubes in 2D monolayers of cancer cells and in 3D spheroids using a portable Raman probe.
2011 Russell Varian Prize for Innovation in Nuclear Magnetic Resonance
Agilent Technologies Inc. announces Gareth Alun Morris, professor of physical chemistry at the University of Manchester, as the winner of the 2011 Russell Varian Prize.
Accessing Protein Conformational Ensembles Using Room-Temperature X-Ray Crystallography
This article describes how monitoring room-temperature conformational ensembles by X-ray crystallography can reveal motions crucial for catalysis, ligand binding, and allosteric regulation.
Tecan and Artel Partner to Offer QC Kit
QC Kit - a fully integrated performance verification solution for Freedom EVO® workstations.
LipoScience Names Timothy J. Fischer Chief Operating Officer
LipoScience Names Timothy J. Fischer Chief Operating Officer In his new role, Mr. Fischer will oversee research and development, commercial operations and medical affairs.
BMG LABTECH is a Diamond Sponsor of the First Annual SLAS 2012
Stop by booth #921 to see The Microplate Reader Company and to see what is new with microplate reader technology.
BioTek Continues International Growth with Launch of BioTek France
BioTek France team includes Dr. Dirk Frese, Philippe Vivier, Damien Brechet and Lionel Capelle.
FEI Collaborates with NIH to Create New ‘Living Lab’ for Structural Biology Research
Collaboration combines electron microscopy, NMR and X-ray diffraction methods to provide advances in structural biology using cryo-EM to accelerate discoveries about the causes, treatments and cures for disease.
BioTek Offers Service Through Serlabo in France
Serlabo will provide IQ/OQ/PQ, primary training, service, preventative maintenance and service contracts for users of BioTek's microplate instrumentation.
Bruker and Berkeley Lab Collaborate on Novel Technology for Structural Biology
Berkeley Lab and Bruker intend to integrate SAXS and NMR data for 3D structure determination of multi-domain proteins and protein complexes with DNA, RNA or other proteins.
Winner of 2012 Winter Conference Award in Plasma Spectrochemistry Announced
Dr. J. Sabine Becker is head of Trace and UltraTrace Analysis, Central Division of Analytical Chemistry at the Research Center Juelich, Germany.
Starna Scientific Appoints Director
Nathan Hulme has been appointed to help guide the company’s expansion plans.
Photonex 2011 - Leading Speakers Announced for the Biophotonics Programme
Register for this free event now as seats are limited.
QC Kit - a fully integrated performance verification solution for Freedom EVO® workstations.
LipoScience Names Timothy J. Fischer Chief Operating Officer
LipoScience Names Timothy J. Fischer Chief Operating Officer In his new role, Mr. Fischer will oversee research and development, commercial operations and medical affairs.
BMG LABTECH is a Diamond Sponsor of the First Annual SLAS 2012
Stop by booth #921 to see The Microplate Reader Company and to see what is new with microplate reader technology.
BioTek Continues International Growth with Launch of BioTek France
BioTek France team includes Dr. Dirk Frese, Philippe Vivier, Damien Brechet and Lionel Capelle.
FEI Collaborates with NIH to Create New ‘Living Lab’ for Structural Biology Research
Collaboration combines electron microscopy, NMR and X-ray diffraction methods to provide advances in structural biology using cryo-EM to accelerate discoveries about the causes, treatments and cures for disease.
BioTek Offers Service Through Serlabo in France
Serlabo will provide IQ/OQ/PQ, primary training, service, preventative maintenance and service contracts for users of BioTek's microplate instrumentation.
Bruker and Berkeley Lab Collaborate on Novel Technology for Structural Biology
Berkeley Lab and Bruker intend to integrate SAXS and NMR data for 3D structure determination of multi-domain proteins and protein complexes with DNA, RNA or other proteins.
Winner of 2012 Winter Conference Award in Plasma Spectrochemistry Announced
Dr. J. Sabine Becker is head of Trace and UltraTrace Analysis, Central Division of Analytical Chemistry at the Research Center Juelich, Germany.
Starna Scientific Appoints Director
Nathan Hulme has been appointed to help guide the company’s expansion plans.
Photonex 2011 - Leading Speakers Announced for the Biophotonics Programme
Register for this free event now as seats are limited.
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Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data
ACD Labs
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
Characterizing a Nasal Spray Formulation from Droplet to API Particle size
Malvern Instruments
Interaction of a nasal spray product with the patients’ body depends on key variables such as the particle size of the delivered droplets and the suspended active pharmaceutical ingredient (API). The particle size of the drug can be an important parameter for the rate of dissolution and availability to sites of action within the nose.
Trace Analysis of Isothiazolinones in Water Samples by Large-Volume Direct Injection Liquid Chromatography Tandem Mass Spectrometry
KWR
Isothiazolinones are used as preservatives, biocides and desinfectants in variety of industrial and domestic applications. The purpose of this study was to develop and optimize an LC–MS/MS method that would enable the determination without any derivatization or preconcentration step of isothiazolinones used in membrane technology for water purification and in household products, at levels relevant for the water cycle.
An improved data processing pipe-line for comprehensive H-NMR and X/MS -omics data
Dept. Analytical Chemistry
In the post acqusition analysis of comprehensive -omics data the pre-processing pipe-line is crucial to extract the maximum possible amount of information from the data. Here we show a processing pipe-line for (1D)H-NMR and (2D)X/MS data comprising; feature detection, inter-sample feature alignment and internal-standard free normalization that outperforms today’s state-of-the-art processing schemes.
Alignment of 1H-NMR data using a Generalized Fuzzy Hough Transform
Stockholm University,Astra Zeneca
In metabolic profiling, multivariate data analysis techniques are used to interpret 1D 1H–NMR data. Multivariate data analysis techniques require that peaks are located in the same variables in every spectrum – this requirement is not met in native NMR spectra. Current state-of-the-art alignment algorithms are unable to align peaks when the spatial order of the peaks changes. We present the Fuzzy Generalized Hough Transform alignment which solves the alignment problem.
1H NMR for the Accurate Quantification of Analytical Reference Standards
Delft University of Technology / Universidade Estadual do Norte Fluminense
NMR can be used for the quantification of minute quantities of standard compounds. The high specificity of NMR signals permits absolute quantifications independent of the presence of impurities. The feasibility and limits of NMR application are demonstrated through the analysis of algal toxins and polar substances in butter.
Achieving Great Science : Bringing Together Physical Measurements and Chemical Analysis
ACD Labs
Many problems in analytical spectroscopy require insight from several different techniques to adequately resolve the problem. A common difficulty with using several techniques is often the ability to manage the various data types and making the data available for review, analysis and reporting.
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data
ACD Labs
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
Characterizing a Nasal Spray Formulation from Droplet to API Particle size
Malvern Instruments
Interaction of a nasal spray product with the patients’ body depends on key variables such as the particle size of the delivered droplets and the suspended active pharmaceutical ingredient (API). The particle size of the drug can be an important parameter for the rate of dissolution and availability to sites of action within the nose.
Trace Analysis of Isothiazolinones in Water Samples by Large-Volume Direct Injection Liquid Chromatography Tandem Mass Spectrometry
KWR
Isothiazolinones are used as preservatives, biocides and desinfectants in variety of industrial and domestic applications. The purpose of this study was to develop and optimize an LC–MS/MS method that would enable the determination without any derivatization or preconcentration step of isothiazolinones used in membrane technology for water purification and in household products, at levels relevant for the water cycle.
An improved data processing pipe-line for comprehensive H-NMR and X/MS -omics data
Dept. Analytical Chemistry
In the post acqusition analysis of comprehensive -omics data the pre-processing pipe-line is crucial to extract the maximum possible amount of information from the data. Here we show a processing pipe-line for (1D)H-NMR and (2D)X/MS data comprising; feature detection, inter-sample feature alignment and internal-standard free normalization that outperforms today’s state-of-the-art processing schemes.
Alignment of 1H-NMR data using a Generalized Fuzzy Hough Transform
Stockholm University,Astra Zeneca
In metabolic profiling, multivariate data analysis techniques are used to interpret 1D 1H–NMR data. Multivariate data analysis techniques require that peaks are located in the same variables in every spectrum – this requirement is not met in native NMR spectra. Current state-of-the-art alignment algorithms are unable to align peaks when the spatial order of the peaks changes. We present the Fuzzy Generalized Hough Transform alignment which solves the alignment problem.
1H NMR for the Accurate Quantification of Analytical Reference Standards
Delft University of Technology / Universidade Estadual do Norte Fluminense
NMR can be used for the quantification of minute quantities of standard compounds. The high specificity of NMR signals permits absolute quantifications independent of the presence of impurities. The feasibility and limits of NMR application are demonstrated through the analysis of algal toxins and polar substances in butter.
Achieving Great Science : Bringing Together Physical Measurements and Chemical Analysis
ACD Labs
Many problems in analytical spectroscopy require insight from several different techniques to adequately resolve the problem. A common difficulty with using several techniques is often the ability to manage the various data types and making the data available for review, analysis and reporting.
BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
BMG LABTECH
The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech
This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability
BMG Labtech
The blood fluke Schistosoma is a parasitic trematode that is responsible for more than 200,000 human deaths per year. The state of the art to detect Schistosoma viability involves microscopy and knowledge of parasite morphology. The lack of appropriate methods for quantifying Schistosoma viability blocks the development of new anthelmintics.
The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
BMG LABTECH
ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
BMG Labtech
During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.
An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega
BMG LABTECH
G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.
Pathway independent cell-based assays on the EnSpire Multimode Plate Reader with Epic® label-free technology
PerkinElmer
This application note details how the PerkinElmer EnSpire® Multimode Plate Reader with Corning® Epic® label-free technology can be used in multi-well microplate formats to non-invasively identify and characterize multiple G protein-coupled receptor (GPCR) pathways in living cells using an orthogonal approach.
Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
PerkinElmer
In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
Quantitative Determination of Caffeine in Beverages and soft Drinks Using UV Wavelength Spectroscopy
Jenway
Numerous studies, employing a wide variety of methods, have been carried out to determine the typical caffeine content of commonly consumed beverages. This application note details how UV spectroscopy can be used to analyse and quantify the caffeine content of some common beverages and soda drinks.
Quantitative Determination of the Aspirin Content of Tablets Using UV and Visible Wavelength Spectroscopy
Jenway
The aspirin content of commercial tablets is routinely determined using the acid/base titration method. This application note details the UV and Visible spectrophotometric methods for determining the aspirin content of tablets.
BMG LABTECH
The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech
This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability
BMG Labtech
The blood fluke Schistosoma is a parasitic trematode that is responsible for more than 200,000 human deaths per year. The state of the art to detect Schistosoma viability involves microscopy and knowledge of parasite morphology. The lack of appropriate methods for quantifying Schistosoma viability blocks the development of new anthelmintics.
The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
BMG LABTECH
ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
BMG Labtech
During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.
An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega
BMG LABTECH
G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.
Pathway independent cell-based assays on the EnSpire Multimode Plate Reader with Epic® label-free technology
PerkinElmer
This application note details how the PerkinElmer EnSpire® Multimode Plate Reader with Corning® Epic® label-free technology can be used in multi-well microplate formats to non-invasively identify and characterize multiple G protein-coupled receptor (GPCR) pathways in living cells using an orthogonal approach.
Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
PerkinElmer
In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
Quantitative Determination of Caffeine in Beverages and soft Drinks Using UV Wavelength Spectroscopy
Jenway
Numerous studies, employing a wide variety of methods, have been carried out to determine the typical caffeine content of commonly consumed beverages. This application note details how UV spectroscopy can be used to analyse and quantify the caffeine content of some common beverages and soda drinks.
Quantitative Determination of the Aspirin Content of Tablets Using UV and Visible Wavelength Spectroscopy
Jenway
The aspirin content of commercial tablets is routinely determined using the acid/base titration method. This application note details the UV and Visible spectrophotometric methods for determining the aspirin content of tablets.
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