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Friday, December 19, 2014
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Using Metabolomics to Study Malaria...
World of Technology & Science 2014...Quantification of Bacterial DNA for Meta...Algae for food, feed and fuel...

Featured Products
Featured Product - Jenway 7310 and 7315 Spectrophotometers
Jenway 7310 and 7315 Spectrophotometers

Webcasts
Webcast - Characterizing the Early Drug Development Outsourcing Landscape Characterizing the Early Drug Development Outsourcing Landscape
Stella Stergiopoulos, Tufts Center for the Study of Drug Design, speaking at Drug Discovery and Development 2014
Webcast - Small Footprint Capillary-Flow NMR and the Process EnvironmentSmall Footprint Capillary-Flow NMR and the Process Environment
John Frost, Thermo Fisher Scientific, speaking at Flow Chemistry Congress 2014

Market Reports
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Molecular Spectroscopy Market by Technology & Application - Forecast to 2018
MarketsandMarkets

Over the years, the molecular spectroscopy market, comprising instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of molecular spectroscopy applications.
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Pathways to Efficient Drug Development - Advances in Modeling and Simulation Outcomes to Fuel Pipeline Productivity
GBI Research

The report examines the reasons why the pharmaceutical industry is looking for improvements in efficiency whilst acknowledging that pharmaceutical R&D remains a long and risky process. It looks in detail at precompetitive research and evaluates how the industry is pulling together to research solutions to problems that are common to all companies.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Single Cell Omics 2011
Select Biosciences Ltd

The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Scientific News
Raman Spectroscopy May Enable Non-Invasive Diagnosis of Bone Diseases
Detection of a genetic ‘brittle bone’ disease known as Osteogenesis Imperfecta (OI) is possible by simply scanning a patient’s limbs.
New Test For Detecting Horse Meat
New test compares differences in chemical compositions of the fat found in meats.
Turkeys may be Lifesavers
Antibiotic to target staph infections, strep, comes from good bacteria in turkeys.
Did You Hear The One About The Two Businessmen On A Plane?
EquipNet’s vision ‘to revolutionize the way companies manage their surplus assets’ was first conceived at 30,000 feet somewhere between Chicago and Boston in 1999. Here we learn more about the company's first 15 years.
Research to Assist Forensic Investigations
Grant will see OSU professor Dr Barry Lavine research the analysis of automobile paint samples to improve how forensic scientists track down vehicles in criminal investigations.
Watching the Hidden Life of Materials
Ultrafast electron diffraction experiments open a new window on the microscopic world.
An Unlikely Use for Diamonds
Tiny diamonds provide new possibilities for accurate measurements of processes inside living cells with potential to improve drug delivery and cancer therapeutics.
Chemists Show That ALS is a Protein Aggregation Disease
Using a technique that illuminates subtle changes in individual proteins, chemistry researchers at Cornell have uncovered new insight into the underlying causes of Amyotrophic Lateral Sclerosis (ALS).
New Catalyst could Improve Production of Biofuels
Washington State University researchers have developed a new catalyst that could lead to making biofuels cheaply and more efficiently.
A Molecular Physics Experience Through Movement at Stanford
dS, short for danceroom Spectroscopy, is the world's first large-scale, interactive molecular physics experience.
Business News
Spinnovation Receives Good Manufacturing Practices Certification
Certification for testing drug substances and drug products to support market release.
Sigma-Aldrich Stockholders Approve Merck Acquisition
The transaction, expected to close mid-2015, remains subject to the satisfaction of the closing conditions set forth in the merger agreement, including regulatory approvals.
ZoBio, Domainex Partner to support FORMA Therapeutics’ Drug Discovery Programs
ZoBio and Domainex Ltd. announce a collaboration with FORMA Therapeutics to provide NMR-based structural biology services for a substantial panel of FORMA drug targets.
Renishaw Receives Queen's Award for Spectroscopy Developments
Award was granted for the continuous development of the company's inVia Raman microscope.
Conference Review: 11th Confocal Raman Imaging Symposium
Raman community presents and discuss its latest scientific results at the conference.
Thermo Fisher Q3 Revenues up 31 Percent
Thermo Fisher announced that revenues grew 31% to $4.17 billion for the third quarter ended September 27, 2014.
Anatrace, Microlytic Partnership to Enable Membrane Protein Research
Partnership will develop and commercialize Analytic, a new brand of products targeted to the membrane protein research community.
Agilent to Close NMR Business
The announcement is part of Agilent's strategy to address the business shortfalls of its Research Products Division.
Rangatira Increases Stake in Magritek
Investment reflects Rangatira’s aim to invest in growing, internationally competitive New Zealand businesses.
Sinensis Life Sciences Acquires Spinnovation
Addition of Spinnovation expands and strengthens Company’s chemical R&D group.

Events
SLAS2015
07 Feb 2015
SLAS2015 ...
European Winter Conference on
22 Feb 2015
European Winter Conference on ...
Pittcon 2015
08 Mar 2015
Pittcon 2015 ...
BIT
25 Apr 2015
BIT's 4th Annual Conference an ...

ePosters
LC-MS/MS METHOD FOR THE QUANTIFICATION OF PITOFENONE IN HUMAN PLASMA
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Mysore – 570 015, Karnataka, India

We developed LCMS/MS bioanalytical method for quantitative estimation of Pitofenone HCl in plasma is simple, sensitive, accurate, precise, and selective. Percentage recovery shows that the method is free from interference of matrix. The analytical method presented here has proved to be useful for investigation of the characteristics of Pitofenone in human plasma in pharmacokinetic and pharmacogenetic studies.
Experimental Evolution in Diatoms - Thermal longterm acclimation in two model diatom species
1 University of East Anglia, School of Environmental Science, Norwich, UK 2Institute of Evolutionary Biology, University of Edinburgh, Kings Building, Ashworth Laboratories, West

Experimental Evolution in two model Diatoms
Antioxidant and Free Radicals Scavenging Activity of Biomolecules: Hydroxamic Acids
School of Study in Chemistry, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

In the present poster attention is focused towards the investigation of antioxidant and free radicals scavenging activity of N-aryl substituted hydroxamic acids by DPPH method which is based on the reduction of alcoholic DPPH solutions in presence of a hydrogen donating antioxidant, hydroxamic acids.
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
Efficacy of Gene Therapy in Restoring Vision in Leber's Congenital Amaurosis
Open University

The research reviews current knowledge of the genetic causes of Leber's congenital amaurosis (LCA) and the development of a gene therapy intervention for LCA. The efficacy as well as the limitations of this form of treatment are evaluated in detail and recommendations are made for the future directions of gene therapy for Leber's congenital amaurosis.

METHOD DEVELOPMENT FOR THE SIMULTANEOUS DETERMINATION OF METHYLMERCURY AND INORGANIC MERCURY IN SEAFOOD
University of Barcelona, Universidade Federal do Rio Grande do Sul

This work reports the method development for the simultaneous determination of methylmercury (MeHg+) and inorganic mercury (iHg) species in seafood. The study focused on the extraction and quantification of MeHg+ by liquid chromatography coupled to on-line UV irradiation and cold vapour atomic fluorescence spectroscopy (LC-UV-HG-AFS), using HCl 4 mol L-1 as extractant agent.
Microextraction techniques combined with X-ray fluorescence spectrometry for determination of different metal ions in water
(a) Institute of Chemistry, University of Silesia, Szkolna 9, 40-006 Katowice, Poland (b) Department of Chemistry, University of Girona, Campus Montilivi s/n, 17170-Girona, Spain (c) Institute of Eart

In present work new preconcentration procedures combining microextraction techniques and X-ray fluorescence spectroscopy were developed. Proposed methodologies are promising tools for multielemental analysis enabling detection of natural pollutants in different water samples.

Artificial Multi-Gene Expression Systems Design Service for Natural Compound Formation and Hetero Protein Complexes
ATG:biosynthetics GmbH, IStLS

Drug discovery of natural compounds drug development and drug target analyses as well as bioproduction can benefit from artificial genetic systems and constructions. The direction in which genes are to be developed is written in the genomes. Synthesis oriented genomic analyses of codon bias and tRNA adaption analyses are prerequisites for generating adaptive, highly functional genes.
Identifying Molecular Signatures of Tumors Using Novel Fluorescence Resonance Energy Transfer Networks
Duke University

We developed FRET sensors that can detect 125 fluorophores simultaneously. From experimental analyses of over 1200 time-resolved fluorescence signatures on 300 prototypical sensors, we show that the optical responses are highly repeatable and minor variations between FRET networks can be discriminated resulting in a total of 10^375 unique responses in theory.

Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Department of Chemistry, Virginia Tech,Virginia Tech Carilion Research Institute

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.
Application Notes
Pharmaceutical Excipient Characterization
Malvern Instruments Limited


Quantifying shear thinning behavior on a rotational rheometer using the power law model
Malvern Instruments Limited

This application note shows how the power law model can be used to quantify shear thinning behavior and for comparing between products and formulations.
Quantifying viscosity recovery following extrusion or spraying using thixotropy assessment on a rotational rheometer
Malvern Instruments Limited

This app note shows how a three step shear rate test can be used to evaluate the extent of viscosity recovery following extrusion from a tube or bottle.
Measuring Exosome Stability with Nanoparticle Tracking Analysis
Malvern Instruments Limited

Here, an LM10 is used to measure the size and concentration of exosomes after storage at two different temperatures, 4°C and room temperature.
Live Cell Biosensor Assay Used To Interrogate GPCRs - Comparative Analysis of Biosensor Variants
BioTek Instruments

This application note compares the performance of the highest and lowest affinity variants using automated methods and the highly-sensitive bottom reading capabilities of an HTS microplate reader. Sensitive detection of the 22F basal signal allows for use of this variant under a broad range of conditions, providing an assay with both superior dynamic range and sensitivity.
Automation of a Homogeneous Proximity Assay for Immunogenicity Testing of Biological Drug Products
BioTek Instruments

Several challenges have surfaced during clinical evaluation of biological drug products due to a commonly associated immune response in patients. Anti-drug antibodies (ADA) are known to be frequently generated during administration of humanized monoclonal antibody therapeutics. A commonly used technology platform for assessment of immunogenicity relies on the bridging immunogenicity assay format typical of the ELISA.
Determination of Antioxidant potential using an Oxygen Radical Absorbance Capacity (ORAC) Assay with Synergy™ H4
BioTek Instruments

The oxygen radical absorbance capacity (ORAC) assay has emerged as a robust analytical method to determine the antioxidant potential of a range of substances found in neutraceutical, pharmaceutical and food products. This application note demonstrates the ability to perform the assay in a 96-well microplate format amenable to higher throughput platforms.
Micro-Volume Purity Assessment of Nucleic Acids using A260/A280 Ratio and Spectral Scanning
BioTek Instruments

The spectrophotometric ratio of absorbance measurements at 260 nm and 280 nm provides a rapid indication of protein contamination in nucleic acid isolates and less commonly, nucleic acid contamination in protein isolates. UV-Vis scanning can also identify contamination from chemical additives used in the isolation procedure. This application note assesses the capability in micro-volume analysis using the BioTek Take3™ microplate accessory.
BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
BMG LABTECH

The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech

This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
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