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 | Towards the Systematic Exploration of Chemical Space: Design, Synthesis and Exploitation of Diverse Small Molecular Libraries Dr Richard Doveston, University of Leeds, speaking at Discovery Chemistry Congress 2013. |
 | Microfluidic Systems for the Analysis of Mass-limited Samples Han Gardeniers, University of Twente, speaking at European Lab Automation 2012 |
Lab Instrument Rental Trends 2012
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Life Science and Chemical Instrumentation Market (2011 - 2016)
MarketsandMarkets
Spectroscopy, Chromatography, DNA Sequencer & Amplifier, Lab Automation, Array, Flow Cytometer, Electrophoresis, Immuno Assay & Others
Single Cell Omics 2011
Select Biosciences Ltd
The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Top 10 Drug Discovery Technologies - Strategic Analysis and Global Forecasts
MarketsandMarkets
The top 10 drug discovery technologies play a vital role in the growth of the entire pharmaceutical industry as they are the key contributors in the swift introduction of blockbusters and innovative drugs. The applications of these technologies in the introduction of drugs have created significant opportunities for market growth. The slow introduction of new blockbuster drugs is a major concern which the drug development companies are catering to by using these top technologies.
1H NMR Spectroscopic Quantification of Plasma Metabolites in Dialysate during Hemodialysis
Researchers from Tohoku University have examined the feasibility of using TSP as a quantitative standard of dialysate.
Use of FT-IR Spectra and PCA to the Bulk Characterization of Cell Wall Residues of Fruits and Vegetables Along a Fraction Process
The study has demonstrated that discrimination between the cell wall residues of fruits and vegetables is possible with the use of FT-IR spectra analysed using the PCA method.
Analysis of Sulfur and Chlorine in Oil by Energy Dispersive X-ray Fluorescence
Monitoring the sulfur and chlorine content is critical in the production of various oils and oil products.
Triple Resonance Three-Dimensional Protein NMR: Before it Became a Black Box
This account provides a personal perspective on three-dimensional triple resonance experiments, providing some historical background.
Watery Research Theme to Flow Through New Tokmakoff Lab
Andrei Tokmakoff to use the world’s shortest infrared light pulses to pluck molecular bonds.
Breakthrough Study Opens Door to Broader Biomedical Applications for Raman Spectroscopy
Wavelength modulation overcomes obstacles to in-situ and in-vivo use – results published in Biomedical Spectroscopy and Imaging.
Raman Microspectroscopy as a Biomarking Tool for In Vitro Diagnosis of Cancer: A Feasibility Study
The potential of Raman and infrared spectroscopy to become complementary to standard histology has recently intensified.
Magnet Sends Lab Capacity ‘Through the Roof’ at Laboratories for Molecular Medicine
As a crane lowered a powerful 3.8-ton magnet through the roof, Brown began work on deploying a powerful new tool for molecular biology research.
Improving the Accuracy of Cancer Diagnoses
New spectroscopy technique could help doctors better identify breast tumors.
A Non-Invasive Method for Estimating Skin Thickness
A novel application of near infrared (NIR) spectroscopy offers skin specialists the ability to monitor skin for medical and cosmetic purposes in a cost-effective and harmless manner.
Researchers from Tohoku University have examined the feasibility of using TSP as a quantitative standard of dialysate.
Use of FT-IR Spectra and PCA to the Bulk Characterization of Cell Wall Residues of Fruits and Vegetables Along a Fraction Process
The study has demonstrated that discrimination between the cell wall residues of fruits and vegetables is possible with the use of FT-IR spectra analysed using the PCA method.
Analysis of Sulfur and Chlorine in Oil by Energy Dispersive X-ray Fluorescence
Monitoring the sulfur and chlorine content is critical in the production of various oils and oil products.
Triple Resonance Three-Dimensional Protein NMR: Before it Became a Black Box
This account provides a personal perspective on three-dimensional triple resonance experiments, providing some historical background.
Watery Research Theme to Flow Through New Tokmakoff Lab
Andrei Tokmakoff to use the world’s shortest infrared light pulses to pluck molecular bonds.
Breakthrough Study Opens Door to Broader Biomedical Applications for Raman Spectroscopy
Wavelength modulation overcomes obstacles to in-situ and in-vivo use – results published in Biomedical Spectroscopy and Imaging.
Raman Microspectroscopy as a Biomarking Tool for In Vitro Diagnosis of Cancer: A Feasibility Study
The potential of Raman and infrared spectroscopy to become complementary to standard histology has recently intensified.
Magnet Sends Lab Capacity ‘Through the Roof’ at Laboratories for Molecular Medicine
As a crane lowered a powerful 3.8-ton magnet through the roof, Brown began work on deploying a powerful new tool for molecular biology research.
Improving the Accuracy of Cancer Diagnoses
New spectroscopy technique could help doctors better identify breast tumors.
A Non-Invasive Method for Estimating Skin Thickness
A novel application of near infrared (NIR) spectroscopy offers skin specialists the ability to monitor skin for medical and cosmetic purposes in a cost-effective and harmless manner.
Analytik Jena Establishes Subsidiary in Thailand
New company to bolster Analytik Jena’s activities in the Southeast Asian market.
Dr. Hashim M. Al-Hashimi Receives Agilent Thought Leader Award
Agilent supports University of Michigan Professor’s work developing transformative NMR applications for structural biology.
Thermo Fisher Scientific to Acquire Life Technologies Corporation
The definitive agreement will see Thermo Fisher will acquire Life Technologies for $76.00 in cash per fully diluted common share or approximately $13.6 billion.
Analytik Jena Increases Stake in Ilmenau-Based ETG to 80.0%
ETG already generates approximately 85.0% of its sales with Analytik Jena.
FACSS Announces the Addition of a New Member Organization
The Federation of Analytical Chemistry and Spectroscopy Societies announces that the Council for Near-Infrared Spectroscopy (CNIRS) has been admitted to the federation as a full member organization.
Oxford Instruments Awarded Best Technology Company 2012
Company has won the award for Best Technology at the annual PLC Awards.
Agilent and Spain’s Centre for Omic Sciences to Collaborate
Both Companies collaborate on integrated systems biology research, establish centre of excellence.
Bruker Opens Two New Centers of Excellence in Mumbai and Bengaluru
The applications, training and service centers will offer extended applications laboratories and customer support capabilities.
Agilent Releases Chromatography and Spectroscopy Catalog
The 2013 catalog lists thousands of products with part numbers, descriptions and configurations, as well as hundreds of applications.
Record Revenues for Thermo Fisher Scientific
Revenue for the quarter grew 6% to $3.26 billion in 2012, versus $3.09 billion in 2011.
New company to bolster Analytik Jena’s activities in the Southeast Asian market.
Dr. Hashim M. Al-Hashimi Receives Agilent Thought Leader Award
Agilent supports University of Michigan Professor’s work developing transformative NMR applications for structural biology.
Thermo Fisher Scientific to Acquire Life Technologies Corporation
The definitive agreement will see Thermo Fisher will acquire Life Technologies for $76.00 in cash per fully diluted common share or approximately $13.6 billion.
Analytik Jena Increases Stake in Ilmenau-Based ETG to 80.0%
ETG already generates approximately 85.0% of its sales with Analytik Jena.
FACSS Announces the Addition of a New Member Organization
The Federation of Analytical Chemistry and Spectroscopy Societies announces that the Council for Near-Infrared Spectroscopy (CNIRS) has been admitted to the federation as a full member organization.
Oxford Instruments Awarded Best Technology Company 2012
Company has won the award for Best Technology at the annual PLC Awards.
Agilent and Spain’s Centre for Omic Sciences to Collaborate
Both Companies collaborate on integrated systems biology research, establish centre of excellence.
Bruker Opens Two New Centers of Excellence in Mumbai and Bengaluru
The applications, training and service centers will offer extended applications laboratories and customer support capabilities.
Agilent Releases Chromatography and Spectroscopy Catalog
The 2013 catalog lists thousands of products with part numbers, descriptions and configurations, as well as hundreds of applications.
Record Revenues for Thermo Fisher Scientific
Revenue for the quarter grew 6% to $3.26 billion in 2012, versus $3.09 billion in 2011.
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Processing and Managing Analytical Data to Extract and Share Knowledge – How Far We’ve Come and Why It’s So Hard?
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data
ACD Labs
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
Characterizing a Nasal Spray Formulation from Droplet to API Particle size
Malvern Instruments
Interaction of a nasal spray product with the patients’ body depends on key variables such as the particle size of the delivered droplets and the suspended active pharmaceutical ingredient (API). The particle size of the drug can be an important parameter for the rate of dissolution and availability to sites of action within the nose.
Trace Analysis of Isothiazolinones in Water Samples by Large-Volume Direct Injection Liquid Chromatography Tandem Mass Spectrometry
KWR
Isothiazolinones are used as preservatives, biocides and desinfectants in variety of industrial and domestic applications. The purpose of this study was to develop and optimize an LC–MS/MS method that would enable the determination without any derivatization or preconcentration step of isothiazolinones used in membrane technology for water purification and in household products, at levels relevant for the water cycle.
An improved data processing pipe-line for comprehensive H-NMR and X/MS -omics data
Dept. Analytical Chemistry
In the post acqusition analysis of comprehensive -omics data the pre-processing pipe-line is crucial to extract the maximum possible amount of information from the data. Here we show a processing pipe-line for (1D)H-NMR and (2D)X/MS data comprising; feature detection, inter-sample feature alignment and internal-standard free normalization that outperforms today’s state-of-the-art processing schemes.
Alignment of 1H-NMR data using a Generalized Fuzzy Hough Transform
Stockholm University,Astra Zeneca
In metabolic profiling, multivariate data analysis techniques are used to interpret 1D 1H–NMR data. Multivariate data analysis techniques require that peaks are located in the same variables in every spectrum – this requirement is not met in native NMR spectra. Current state-of-the-art alignment algorithms are unable to align peaks when the spatial order of the peaks changes. We present the Fuzzy Generalized Hough Transform alignment which solves the alignment problem.
1H NMR for the Accurate Quantification of Analytical Reference Standards
Delft University of Technology / Universidade Estadual do Norte Fluminense
NMR can be used for the quantification of minute quantities of standard compounds. The high specificity of NMR signals permits absolute quantifications independent of the presence of impurities. The feasibility and limits of NMR application are demonstrated through the analysis of algal toxins and polar substances in butter.
Advanced Chemistry Development Inc.
This paper discusses the ACD/Spectrus Processor, the new all-in-one analytical data processing and chemical characterization software.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
SpectraMax® Microplate Readers: A complete solution for Transcreener® assays
Molecular Devices
Transcreener® ADP2 Assays are homogenous assays with fluorescent readouts that enable the detection and screening of established drug targets including protein and lipid kinases, as well as emerging targets such as carbohydrate kinases, triphosphatases, heat shock proteins and other ATPases.
Ensuring the Quality of Registered Compounds in a Drug Discovery Environment – A Multidisciplinary Approach
ACD Labs
Lexicon Pharmaceuticals have demonstrated that a practical automated verification system using HPLC, LC/MS, and 1D and 2D NMR can be implemented in an industrial/pharmaceutical environment. This system has proven to be robust, and provides added value to compound collection integrity and quality.
A Self-Monitoring Quality Management System Incorporating Spectral and Chromatographic Data
ACD Labs
LIMS are useful in managing certain types of data for quality management and sample tracking. However, these systems are generally limited in the types of information they can process and store. A unique automated quality management system has been developed and implemented at a fragrance manufacturer to evaluate chromatographic and spectral data of samples during quality testing.
Characterizing a Nasal Spray Formulation from Droplet to API Particle size
Malvern Instruments
Interaction of a nasal spray product with the patients’ body depends on key variables such as the particle size of the delivered droplets and the suspended active pharmaceutical ingredient (API). The particle size of the drug can be an important parameter for the rate of dissolution and availability to sites of action within the nose.
Trace Analysis of Isothiazolinones in Water Samples by Large-Volume Direct Injection Liquid Chromatography Tandem Mass Spectrometry
KWR
Isothiazolinones are used as preservatives, biocides and desinfectants in variety of industrial and domestic applications. The purpose of this study was to develop and optimize an LC–MS/MS method that would enable the determination without any derivatization or preconcentration step of isothiazolinones used in membrane technology for water purification and in household products, at levels relevant for the water cycle.
An improved data processing pipe-line for comprehensive H-NMR and X/MS -omics data
Dept. Analytical Chemistry
In the post acqusition analysis of comprehensive -omics data the pre-processing pipe-line is crucial to extract the maximum possible amount of information from the data. Here we show a processing pipe-line for (1D)H-NMR and (2D)X/MS data comprising; feature detection, inter-sample feature alignment and internal-standard free normalization that outperforms today’s state-of-the-art processing schemes.
Alignment of 1H-NMR data using a Generalized Fuzzy Hough Transform
Stockholm University,Astra Zeneca
In metabolic profiling, multivariate data analysis techniques are used to interpret 1D 1H–NMR data. Multivariate data analysis techniques require that peaks are located in the same variables in every spectrum – this requirement is not met in native NMR spectra. Current state-of-the-art alignment algorithms are unable to align peaks when the spatial order of the peaks changes. We present the Fuzzy Generalized Hough Transform alignment which solves the alignment problem.
1H NMR for the Accurate Quantification of Analytical Reference Standards
Delft University of Technology / Universidade Estadual do Norte Fluminense
NMR can be used for the quantification of minute quantities of standard compounds. The high specificity of NMR signals permits absolute quantifications independent of the presence of impurities. The feasibility and limits of NMR application are demonstrated through the analysis of algal toxins and polar substances in butter.
Determination of Antioxidant potential using an Oxygen Radical Absorbance Capacity (ORAC) Assay with Synergy™ H4
BioTek Instruments
The oxygen radical absorbance capacity (ORAC) assay has emerged as a robust analytical method to determine the antioxidant potential of a range of substances found in neutraceutical, pharmaceutical and food products. This application note demonstrates the ability to perform the assay in a 96-well microplate format amenable to higher throughput platforms.
Micro-Volume Purity Assessment of Nucleic Acids using A260/A280 Ratio and Spectral Scanning
BioTek Instruments
The spectrophotometric ratio of absorbance measurements at 260 nm and 280 nm provides a rapid indication of protein contamination in nucleic acid isolates and less commonly, nucleic acid contamination in protein isolates. UV-Vis scanning can also identify contamination from chemical additives used in the isolation procedure. This application note assesses the capability in micro-volume analysis using the BioTek Take3™ microplate accessory.
BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
BMG LABTECH
The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech
This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability
BMG Labtech
The blood fluke Schistosoma is a parasitic trematode that is responsible for more than 200,000 human deaths per year. The state of the art to detect Schistosoma viability involves microscopy and knowledge of parasite morphology. The lack of appropriate methods for quantifying Schistosoma viability blocks the development of new anthelmintics.
The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
BMG LABTECH
ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
BMG Labtech
During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.
An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega
BMG LABTECH
G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.
Pathway independent cell-based assays on the EnSpire Multimode Plate Reader with Epic® label-free technology
PerkinElmer
This application note details how the PerkinElmer EnSpire® Multimode Plate Reader with Corning® Epic® label-free technology can be used in multi-well microplate formats to non-invasively identify and characterize multiple G protein-coupled receptor (GPCR) pathways in living cells using an orthogonal approach.
Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
PerkinElmer
In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
BioTek Instruments
The oxygen radical absorbance capacity (ORAC) assay has emerged as a robust analytical method to determine the antioxidant potential of a range of substances found in neutraceutical, pharmaceutical and food products. This application note demonstrates the ability to perform the assay in a 96-well microplate format amenable to higher throughput platforms.
Micro-Volume Purity Assessment of Nucleic Acids using A260/A280 Ratio and Spectral Scanning
BioTek Instruments
The spectrophotometric ratio of absorbance measurements at 260 nm and 280 nm provides a rapid indication of protein contamination in nucleic acid isolates and less commonly, nucleic acid contamination in protein isolates. UV-Vis scanning can also identify contamination from chemical additives used in the isolation procedure. This application note assesses the capability in micro-volume analysis using the BioTek Take3™ microplate accessory.
BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
BMG LABTECH
The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech
This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability
BMG Labtech
The blood fluke Schistosoma is a parasitic trematode that is responsible for more than 200,000 human deaths per year. The state of the art to detect Schistosoma viability involves microscopy and knowledge of parasite morphology. The lack of appropriate methods for quantifying Schistosoma viability blocks the development of new anthelmintics.
The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
BMG LABTECH
ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
BMG Labtech
During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.
An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega
BMG LABTECH
G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.
Pathway independent cell-based assays on the EnSpire Multimode Plate Reader with Epic® label-free technology
PerkinElmer
This application note details how the PerkinElmer EnSpire® Multimode Plate Reader with Corning® Epic® label-free technology can be used in multi-well microplate formats to non-invasively identify and characterize multiple G protein-coupled receptor (GPCR) pathways in living cells using an orthogonal approach.
Comparison of Performance: EnSpire Multimode Plate Reader and Corning® Epic® System
PerkinElmer
In recent years, label-free technology has gained momentum as an innovative tool in the fields of cellular research and biochemical binding assays. This application note demonstrates the comparable performance of the EnSpire Multimode Plate Reader to the Corning® Epic® System.
