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Small Footprint Capillary-Flow NMR and t...
AC Extraction Plate* with Freedom EVO an...Manual Removal of Push Caps...Catalysis in Flow: Operando Study of Pd ...

Featured Products
Featured Product - Maya2000 Pro-NIR: High-sensitivity Spectrometer for Raman and NIR Applications
Maya2000 Pro-NIR: High-sensitivity Spectrometer for Raman and NIR Applications

Webcasts
Webcast - Small Footprint Capillary-Flow NMR and the Process EnvironmentSmall Footprint Capillary-Flow NMR and the Process Environment
John Frost, Thermo Fisher Scientific, speaking at Flow Chemistry Congress 2014
Webcast - Development of High-content Assays for Compound Screening and Hit ValidationDevelopment of High-content Assays for Compound Screening and Hit Validation
Kamyar Hadian, Helmholtz Zentrum Munchen, speaking at Hight Content Analysis 2014

Market Reports
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Atomic Spectroscopy Market by Technology & Application - Competitive Landscape, Global Forecasts & Trends to 2018
MarketsandMarkets

The global atomic spectroscopy market was valued at an estimated $4.02 billion in 2013 and is expected to grow at a CAGR of 6.4%.
Molecular Spectroscopy Market by Technology & Application - Forecast to 2018
MarketsandMarkets

Over the years, the molecular spectroscopy market, comprising instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of molecular spectroscopy applications.
Multi-Mode Microplate Reader Trends 2013
HTStec

This market report summarizes the results of HTStec’s 4th industry-wide global web-based benchmarking survey on multi-mode microplate readers carried out in September 2013.
Biomarkers
RI Technologies

This report on focuses on the different types of biomarkers and their impact on various disease areas. The study also provides global market analysis for biomarkers by disease area and by prominent biomarker identification technologies.
Pathways to Efficient Drug Development - Advances in Modeling and Simulation Outcomes to Fuel Pipeline Productivity
GBI Research

The report examines the reasons why the pharmaceutical industry is looking for improvements in efficiency whilst acknowledging that pharmaceutical R&D remains a long and risky process. It looks in detail at precompetitive research and evaluates how the industry is pulling together to research solutions to problems that are common to all companies.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Single Cell Omics 2011
Select Biosciences Ltd

The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Scientific News
A Molecular Physics Experience Through Movement at Stanford
dS, short for danceroom Spectroscopy, is the world's first large-scale, interactive molecular physics experience.
Watching Molecules ‘Dance’ in Real Time
Trapping light at the nanoscale enables real-time monitoring of individual molecules bending and flexing may aid in our understanding of how changes within a cell can lead to diseases such as cancer.
How to Prevent Organic Food Fraud
A new test under development has the potential to authenticate organic tomatoes and other produce.
3-in-1 Spectroscopy System Improves Skin Cancer Detection
The new device may detect cancerous skin lesions early on, leading to better treatment outcomes and ultimately saving lives.
Minuscule Chips for NMR Spectroscopy Promise Portability, Parallelization
Two-by-two-millimeter spectrometer dramatically shrinks footprint for multidimensional analysis of molecules.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
New Spectroscopy Technique Provides Unprecedented Look into Photochemical Reactions
Two-dimensional electronic-vibrational spectroscopy can be used to simultaneously monitor electronic and molecular dynamics on a femtosecond time-scale.
X-rays Used to Examine How DNA Protects Itself from UV Light
Scientists have made detailed observations of a “relaxation response” that protects these molecules, and the genetic information they encode, from UV damage.
Using Spectroscopy to Diagnose Skin Cancer
Autofluorescence and diffuse reflectance spectroscopy identify malignant melanoma with 93% accuracy.
Role of Water in Chromosome Spreading and Swelling Induced by Acetic Acid Treatment
Researchers analysed intact lymphocytes before and at each stage of the chromosome preparation protocol by FTIR spectroscopy.
Business News
Pittcon Releases New Website for 2015
New website with viewing compatibility with most mobile platforms.
Freeze Drying Monitoring & Control
SP Scientific enters into an exclusive agreement with PSI to distribute LyoFlux® 200.
Thermo, University of Birmingham Partner to Study Brominated Flame Retardant Pollution
Research aims to increase understanding of the environmental fate and behavior of brominated persistent organic chemicals through deploying recent advances in analytical instrumentation.
Thermo Completes Sale of Cole-Parmer to GTCR
Thermo Fisher Scientific Inc. announced that it has completed the sale of its Cole-Parmer customer channel business to private equity firm GTCR LLC for approximately $480 million in cash.
Intertek Launches Unique Pharmaceutical NMR
Intertek have launched an industry-unique high resolution pharmaceutical Nuclear Magnetic Resonance capability.
Development of Oral Cancer Diagnostic Receives Backing
Zilico Ltd has received funding from the Technology Strategy Board, the UK’s innovation agency.
Thermo to Sell Cole-Parmer for $480M
Company has signed a definitive agreement to sell its Cole-Parmer channel business to private equity firm GTCR, LLC for $480 million in cash.
Analytik Jena AG Completes Merger of CyBio AG
Merger became effective upon entry into the commercial register of Analytik Jena AG.
Biochrom, Gilson Sign ELISA Distribution Agreement
Companies to co-market and distribute products for automation of ELISAs and other absorbance assays in Europe.
Agilent, Seoul National University to Collaborate on New Research Center
The facility will support new drug development center in the university's college of pharmacy.

Events
World of Technology & Science
30 Sep 2014
World of Technology & Science ...
FACSS Presents SciX 2014
28 Sep 2014
FACSS Presents SciX 2014 ...
The application of chromatogra
05 Nov 2014
The application of chromatogra ...
SLAS2015
07 Feb 2015
SLAS2015 ...

ePosters
Design and Evaluation of High Definition Probe for HPV genotyping Microarray
Labgenomics Co., Republic of Korea

To improve the sensitivity and specificity of the HPV DNA Microarray, we adopted triple oligonucleotide probes for each targets and selected these probes not to have higher similarity of 75% with each others. These triple probes have shown 10 ~ 100 times higher sensitivities with comparable specificities than the conventional HPV DNA microarray of single oligonuclotide probe.

Gut Microbial Metabolites and Hepatic Xenobiotic Metabolism: A High Throughput Screening Approach
University of Reading, AstraZeneca

This poster highlights the combination of metabonomics and high throughput screening by the identification of gut microbial metabolites and a screening assay designed to determine their cytotoxicity to liver-like cell cultures.
Digital PCR to Determine the Number of Transcripts from Single Neurons after Patch-clamp Recording
1AVIDIN Ltd., Szeged, Hungary www.avidinbiotech.com; 2Laboratory for Functional Genomics, Biological Research Center, HAS; 3Research Group for Cortical Microcircuits, HAS, Department of Physiology, An

Whole-cell patch-clamp recording enables detecting electrophysiological signals from neurons, and RNA can be harvested into the patch pipette from the cells.We have optimized a dPCR protocol for determining exact transcript numbers in single neurons after patch-clamp recording by using dPCR based on high-density nanocapillary PCR.
Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
1) Swift Analytical Ltd, The Catalyst, Baird Lane, York, YO10 5GW 2) DeNovix Inc, 3411 Silverside Road, Hanby Building, Wilmington, DE 19810 USA

In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.
Mixtures Analysis of Complex Mixtures
Mestrelab Research

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.
A Complete Wine Analysis Using Multiplets Detection
1Mestrelab Research, www.mestrelab.com; 2Institut Heidger, Germany, www.institut-heidger.de

NMR mixtures analysis can be used to determine the concentration of key components in wine. Here we show the analysis using SMA from Mestrelab.
A Novel Approach Toward Microfluidic Drug Metabolite Synthesis – Electrosynthetic Methodology Simulating Cytochrome (CYP450) Oxidation
Sanford Burnham Medical Research Institute at Lake Nona and Syrris Ltd

A novel microfluidic technology and electrochemical synthesis method is demonstrated for the efficient generation of known drug metabolites. These metabolites are typically generated on first pass hepatic oxidation in vivo. The FLUX Module, a new microfluidic electrochemical cell manufactured by Syrris Ltd., has been employed to generate the metabolites of five commercial drugs: Tolbutamide, Chlorpromazine, Diclofenac, Primidone and Albendazole.
A complete workflow from sample preparation to analysis using SureSelect target enrichment system for Ion Proton semiconductor sequencing
Agilent Technologies

Agilent’s SureSelect Target Enrichment for the Ion Proton Platform provides a comprehensive, efficient, robust, and cost-effective means to sequence subsets of the human genome.

Mutation Induction in Sucrose Synthase 1 to Study Cold Acclimation in Winter Wheat
Institute of Agriculture, Lithuanian Research Centre for Agriculture and Forestry

Sucrose synthase (Ss) catalyzes the reversible conversion of sucrose and a nucleoside diphosphate into the corresponding nucleoside diphosphate-glucose and fructose being one of the main enzymes of carbohydrate metabolism. The objectives of this study were: to create a TILLING population in winter wheat; to identify new alleles of Ss1 gene; to compare relative expression of Ss1 in leaves and crowns of mutant versus wild type plants during cold acclimation.
Characterization of the prehaustorial resistance against leaf rust (Puccinia triticina f. sp. tritici) in Einkorn (Triticum monococcum) by massive analysis of cDNA ends (MACE)
1 Julius Kuehn-Institute (JKI) Federal Research Centre for Cultivated Plants, Institute for Resistance Research and Stress Tolerance, 06484 Quedlinburg, Germany 2 Interdisciplinary Center for Crop Pla

Triticum monococcum, a valuable source for horizontal resistance against P. triticina was analyzed microscopically and by transcriptional profiling. MACE showed the increased expression of chitinases, kinases, peroxidases and pathogenesis related genes in the first 8 hai. The high number of differentially expressd tags and the knowledge about SNPs facilitates in silico mapping and the development of polymorphic markers which may accelerate the transfer of this prehaustorial resistance
Application Notes
Live Cell Biosensor Assay Used To Interrogate GPCRs - Comparative Analysis of Biosensor Variants
BioTek Instruments

This application note compares the performance of the highest and lowest affinity variants using automated methods and the highly-sensitive bottom reading capabilities of an HTS microplate reader. Sensitive detection of the 22F basal signal allows for use of this variant under a broad range of conditions, providing an assay with both superior dynamic range and sensitivity.
Automation of a Homogeneous Proximity Assay for Immunogenicity Testing of Biological Drug Products
BioTek Instruments

Several challenges have surfaced during clinical evaluation of biological drug products due to a commonly associated immune response in patients. Anti-drug antibodies (ADA) are known to be frequently generated during administration of humanized monoclonal antibody therapeutics. A commonly used technology platform for assessment of immunogenicity relies on the bridging immunogenicity assay format typical of the ELISA.
Determination of Antioxidant potential using an Oxygen Radical Absorbance Capacity (ORAC) Assay with Synergy™ H4
BioTek Instruments

The oxygen radical absorbance capacity (ORAC) assay has emerged as a robust analytical method to determine the antioxidant potential of a range of substances found in neutraceutical, pharmaceutical and food products. This application note demonstrates the ability to perform the assay in a 96-well microplate format amenable to higher throughput platforms.
Micro-Volume Purity Assessment of Nucleic Acids using A260/A280 Ratio and Spectral Scanning
BioTek Instruments

The spectrophotometric ratio of absorbance measurements at 260 nm and 280 nm provides a rapid indication of protein contamination in nucleic acid isolates and less commonly, nucleic acid contamination in protein isolates. UV-Vis scanning can also identify contamination from chemical additives used in the isolation procedure. This application note assesses the capability in micro-volume analysis using the BioTek Take3™ microplate accessory.
BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
BMG LABTECH

The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
BMG LabTech

This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.
Quantitative, High-Throughput, Fluorescent-Based Bioassay to Detect Schistosoma Viability
BMG Labtech

The blood fluke Schistosoma is a parasitic trematode that is responsible for more than 200,000 human deaths per year. The state of the art to detect Schistosoma viability involves microscopy and knowledge of parasite morphology. The lack of appropriate methods for quantifying Schistosoma viability blocks the development of new anthelmintics.
The ELISAONE ™ Assay Performed on the POLARstar Omega from BMG LABTECH
BMG LABTECH

ELISAONE ™ technology has been developed by TGR BioSciences to provide a means of running high performance sandwich immunoassays in a user-friendly 96-well format.
Promotion of Aggregation as a Means of Assessing the Stability of Antibody Molecules
BMG Labtech

During manufacture of antibody molecules, they are subjected to mechanical stress generated by processes such as pumping and filtration. This may cause denaturation and consequently aggregation due to exposure of the protein to air-liquid interfaces and shear forces, resulting in the ultimate loss in bioactivity.
An AlphaScreen® SureFire® Phospho-ERK1/2 Assay Performed on BMG LABTECH’s POLARstar Omega
BMG LABTECH

G-protein coupled receptors (GPCRs) are a large family of receptors which have a broad involvement in cellular responses affecting many important body functions both in health and disease.
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