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Synthesis, Characterization and Biological Activity Studies of 1,3,4-Oxadiazole Analogs

Published: Wednesday, February 01, 2012
Last Updated: Wednesday, February 01, 2012
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Some of the compounds prepared were shown to possess remarkable antibacterial, antifungal and anti-inflammatory activities.

Abstract
The reaction of p-bromoanilino acetohydrazide(II) with aromatic aldehydes in alcohol yielded 2-[4-bromo aniline] N-substituted benzylidine hydrazides (IIIa-IIIj), which in presence of yellow mercuric oxide and iodine in DMF, yielded corresponding 4-bromo[(N-5-substituted 1,3,4 oxadiazole-2 -yl)methyl]aniline. Structures of the compounds synthesized were confirmed by IR, 1HNMR and mass spectrometry. The newly synthesized compounds were screened for antibacterial, antifungal and anti-inflammatory activities.

The article is published online in the Journal of Young Pharmacists and is free to access.


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