Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Purdue University Researchers Use Nanoscale IR Spectroscopy via AFM-IR

Published: Friday, May 11, 2012
Last Updated: Friday, May 11, 2012
Bookmark and Share
Utilizing this technique has provided key insights into drug-polymer blends.

Two new papers are going to press featuring the use of Anasys Instruments' nanoIR™ system by Professor Lynne S. Taylor's group in the Department of Industrial and Physical Pharmacy at Purdue University.

In each study, miscibility of pharmaceutically relevant blends was examined and specific sub-micrometer-sized domains characterized using standard atomic force microscopy (AFM) and nanoscale Infrared spectroscopy (AFM-IR).

The first of the two papers, entitled "Nanoscale Mid-Infrared Imaging of Phase Separation in a Drug-Polymer Blend" is being published in the June 2012 issue of the Journal of Pharmaceutical Sciences.

The researchers at Purdue explored the applicability of nanoscale IR spectroscopy and imaging to analyze a partially miscible model pharmaceutical drug-polymer system consisting of felodipine and poly(acrylic acid) (PAA).

By combining AFM topography imaging with AFM-IR chemical information obtained at a high spatial resolution, it was possible to interrogate both the structure and chemical composition of phases in the felodipine-PAA blends.

The second of the papers "Nanoscale Mid-Infrared Evaluation of the Miscibility Behavior of Blends of Dextran or Maltodextrin with Poly(vinylpyrrolidone)" has been accepted for publication in the Journal of Molecular Pharmaceuticals.

In this study, the AFM topography data combined with AFM-IR chemical information provided structural insights into the formation of phase-separated systems.

The size, shape, and distribution of the different domains formed and the dependence of these features on the molecular weights of the polymers was analyzed.

AFM-IR analysis is an important complement to more traditional miscibility evaluation probes currently available in the field.

According to Professor Taylor "being able to obtain infrared spectra at nanoscale spatial resolution is a dramatic development that should provide new insights into the microstructure of pharmaceutical formulations. This will enable us perform in-depth studies that enable relationships between microstructure, processing and product performance to be elucidated."

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,700+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New NIST AFM-IR Publication has Catalysis Research Implications
Anasys Instruments reports on a new publication from their nanoIR users at NIST which assess the chemical composition of a metal-organic framework with nanoscale resolution.
Tuesday, March 25, 2014
Inventor of AFM-IR Technique to Receive Ernst Abbe Memorial Award
Professor Alexandre Dazzi to receive the award for pioneering field of nanoscale IR Spectroscopy.
Wednesday, March 19, 2014
French Researchers to Identify Best Microbes for Biofuel Production
Scientists used atomic force microscopy combined with infrared spectroscopy.
Wednesday, February 19, 2014
Anasys' NIST Users Report on New AFM-IR Nanoscale Chemical Imaging Method
New application for AFM-IR to study in NIST publication "Tech Beat."
Thursday, July 25, 2013
Invited Award Symposium Presentation Nanoscale IR Spectroscopy at Pittcon 2012
Anasys Instruments announced that Dr. Bruce Chase is presenting an invited talk entitled "Structure and Orientation in Electrospun Nanofibers", as part of the Organized Contributed Session on Analytical Applications of Broadly Tunable Lasers.
Thursday, March 08, 2012
Anasys Instruments Receives Microscopy Today’s 2011 Innovation Award
AFM-IR system has been recognized by Microscopy Today in the receipt of the 2011 Innovation Award.
Thursday, August 18, 2011
Scientific News
Analyzing Protein Structures in Their Native Environment
Enhanced-sensitivity NMR could reveal new clues to how proteins fold.
Proteins with ALS, Cancer Role Do Not Assume a Regular Shape
Our cells contain proteins, essential to functions like protein creation and DNA repair but also involved in forms of ALS and cancer, that never take a characteristic shape, a new study shows.
Michigan Researchers Use Raman Spectroscopy
inVia confocal Raman microscope used in the study of various childhood diseases.
Pittcon Announces Sanford Asher as Recipient of the 2016 SACP Award
Asher will accept this prestigious award at Pittcon 2016 in Atlanta, Georgia.
Metamaterial Absorbers for Infrared Inspection Technologies
A metamaterial absorber capable of highly sensitive infrared detection enhances the spectroscopy of tiny molecular details.
Pancreatic Cancer Stem Cells Could be "Suffocated" by Anti-diabetic Drug
A new study shows that pancreatic cancer stem cells (PancSCs) are virtually addicted to oxygen-based metabolism, and could be “suffocated” with a drug already used to treat diabetes.
Marzipan Made From Pure Almonds
Researchers carry out DNA analyses and use advanced protein identification techniques to determine whether marzipan is made from pure almonds or also contains other nuts or beans.
Evidence of Ancient Life Discovered Deep Below the Seafloor
Ancient rocks harbored microbial life deep below the seafloor, reports a team of scientists from the Woods Hole Oceanographic Institution (WHOI), Virginia Tech, and the University of Bremen.
Kwansei Gakuin University in Hyogo, Japan, Uses Raman Microscopy
Raman Microscopy study crystallographic defects in silicon carbide wafers.
Structural Discoveries Could Aid in Better Drug Design
Scientists have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,700+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos