Corporate Banner
Satellite Banner
Spectroscopy
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

BioTools Celebrates Growth of VCD at Chirality Meeting

Published: Monday, July 16, 2012
Last Updated: Monday, July 16, 2012
Bookmark and Share
Vibrational circular dichroism determine the absolute configuration of chiral molecules.

Vibrational circular dichroism (VCD), a new tool for determining the absolute configuration of chiral molecules, was a key highlight of the recent 24th International Symposium on Chirality, held June 10-13 in Fort Worth, Texas.

VCD pioneer, BioTools (Jupiter, FL) was on hand, not only sponsoring the exhibitor’s luncheon and the poster awards, but also proudly awarding the Best Poster Given by a Young Scientist for the thirteenth year.

VCD is especially important for the pharmaceutical industry because the sooner the specific chiral structure is defined, the sooner the bioactivity can be determined.

The drug can then come to market more rapidly, saving money and, often, lives. Many of today’s blockbuster drugs are chiral molecules, including Lipitor, Plavix, and Nexium.

NASA’s Mars program is also interested in VCD because chirality is the ultimate differentiator between just a soup of organic molecules and life.

However, VCD experiments were difficult until BioTools developed the first commercial vibrational circular dichroism spectrometer in partnership with ABB Bomem in 1997.

“We commercialized a new technology that solves fundamental questions which organic chemists encounter every day”, stated BioTool’s president, Dr. Rina Dukor.

Chiral molecules exist widely, both in nature and among man-made materials. Like our own left and right hands, they are non-superimposable mirror images of each other and form pairs of “stereoisomers” or “enantiomorphs.”

Proteins, amino and nucleic acids, carbohydrates and many pharmaceuticals exhibit chirality.

Because our chemistry and that of all biological organisms recognizes and responds only to specific chiral patterns (just the right or just the left stereoisomer), chiral molecules define critical biological activities such as metabolism and drug uptake.

While the VCD experiment to characterize chirality has been challenging, the principle is straightforward. When plane polarized light is passed through a chiral material, this molecular “handed-ness” causes the plane of polarization to rotate.

The direction and amount of rotation are key optical properties. If instead circularly polarized infrared light is used, delicate differences in IR absorption can be measured between the right versus left circularly polarized beams.

These differences arise from vibrational changes (ex: bending and stretching) in the molecular geometry as the material interacts with the IR illumination, providing definitive information about the molecule’s three-dimensional chiral structure and its potential bioactivity.

A quick scan of the Chirality meeting program reveals VCD’s dramatic growth. Originally, the program contained only one technical talk. Now multiple sessions offer over a dozen presentations.

In addition to a symposium dedicated specifically to molecular chirality there are also two sessions on chiral spectroscopy, primarily devoted to VCD or its sister technology, ROA (Raman Optical Activity) which uses the selective scattering of circularly polarized light to make a chemical “fingerprint” of the molecule.

The patent record adds further credence to the spread of this new technology: VCD has been mentioned as the source for the determination of absolute configuration in over 100 patent applications for new chiral molecular entities.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Low-Cost, Portable NQR Spectroscopy
A researcher at Case Western Reserve University is developing a low-cost, portable prototype designed to detect tainted medicines and food supplements that otherwise can make their way to consumers. The technology can authenticate good medicines and supplements.
Structure of Brain Plaques in Huntington's
Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.
Insights into the Function of the Main Class of Drug Targets
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.
The Power of Three
Overlooked portion of cell “death receptor” critical in some cancers, autoimmune diseases.
Revealing the Secrets of 19th Century Fashion Industry
The dye industry of the 19th century was fast-moving and international, according to a state-of-the-art analysis of four purple dresses.
How Nanoparticles Damage Immune Cells
New evidence points to protein oxidation, a common means of molecular damage.
Single Molecule Detection of Contaminants, Explosives or Diseases
A technique that combines the ultrasensitivity of surface-enhanced Raman scattering (SERS) with a slippery surface invented by Penn State researchers will make it feasible to detect single molecules of a number of chemical and biological species from gaseous, liquid or solid samples.
Extracting Uranium from Seawater
An ultra-high-resolution technique used for the first time to study polymer fibers that trap uranium in seawater may cause researchers to rethink the best methods to harvest this potential fuel for nuclear reactors.
Innovation Boosts Study of Fragile Biological Samples
Researchers have found a simple new way to study very delicate biological samples – like proteins at work in photosynthesis and components of protein-making machines called ribosomes – at the atomic scale using SLAC's X-ray laser.
Clues for Battling Botulism
Scientists decipher details of deadly toxin's cloaking mechanism that could guide development of new vaccines, treatments.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!