Corporate Banner
Satellite Banner
Spectroscopy
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

BioTools Celebrates Growth of VCD at Chirality Meeting

Published: Monday, July 16, 2012
Last Updated: Monday, July 16, 2012
Bookmark and Share
Vibrational circular dichroism determine the absolute configuration of chiral molecules.

Vibrational circular dichroism (VCD), a new tool for determining the absolute configuration of chiral molecules, was a key highlight of the recent 24th International Symposium on Chirality, held June 10-13 in Fort Worth, Texas.

VCD pioneer, BioTools (Jupiter, FL) was on hand, not only sponsoring the exhibitor’s luncheon and the poster awards, but also proudly awarding the Best Poster Given by a Young Scientist for the thirteenth year.

VCD is especially important for the pharmaceutical industry because the sooner the specific chiral structure is defined, the sooner the bioactivity can be determined.

The drug can then come to market more rapidly, saving money and, often, lives. Many of today’s blockbuster drugs are chiral molecules, including Lipitor, Plavix, and Nexium.

NASA’s Mars program is also interested in VCD because chirality is the ultimate differentiator between just a soup of organic molecules and life.

However, VCD experiments were difficult until BioTools developed the first commercial vibrational circular dichroism spectrometer in partnership with ABB Bomem in 1997.

“We commercialized a new technology that solves fundamental questions which organic chemists encounter every day”, stated BioTool’s president, Dr. Rina Dukor.

Chiral molecules exist widely, both in nature and among man-made materials. Like our own left and right hands, they are non-superimposable mirror images of each other and form pairs of “stereoisomers” or “enantiomorphs.”

Proteins, amino and nucleic acids, carbohydrates and many pharmaceuticals exhibit chirality.

Because our chemistry and that of all biological organisms recognizes and responds only to specific chiral patterns (just the right or just the left stereoisomer), chiral molecules define critical biological activities such as metabolism and drug uptake.

While the VCD experiment to characterize chirality has been challenging, the principle is straightforward. When plane polarized light is passed through a chiral material, this molecular “handed-ness” causes the plane of polarization to rotate.

The direction and amount of rotation are key optical properties. If instead circularly polarized infrared light is used, delicate differences in IR absorption can be measured between the right versus left circularly polarized beams.

These differences arise from vibrational changes (ex: bending and stretching) in the molecular geometry as the material interacts with the IR illumination, providing definitive information about the molecule’s three-dimensional chiral structure and its potential bioactivity.

A quick scan of the Chirality meeting program reveals VCD’s dramatic growth. Originally, the program contained only one technical talk. Now multiple sessions offer over a dozen presentations.

In addition to a symposium dedicated specifically to molecular chirality there are also two sessions on chiral spectroscopy, primarily devoted to VCD or its sister technology, ROA (Raman Optical Activity) which uses the selective scattering of circularly polarized light to make a chemical “fingerprint” of the molecule.

The patent record adds further credence to the spread of this new technology: VCD has been mentioned as the source for the determination of absolute configuration in over 100 patent applications for new chiral molecular entities.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Kwansei Gakuin University in Hyogo, Japan, Uses Raman Microscopy
Raman Microscopy study crystallographic defects in silicon carbide wafers.
Structural Discoveries Could Aid in Better Drug Design
Scientists have uncovered the structural details of how some proteins interact to turn two different signals into a single integrated output.
X-ray Laser Experiment Could Help in Designing Drugs for Brain Disorders
Scientists found that when two protein structures in the brain join up, they act as an amplifier for a slight increase in calcium concentration, triggering a gunshot-like release of neurotransmitters from one neuron to another.
Team Identifies Structure of Tumor-Suppressing Protein
An international group of researchers led by Carnegie Mellon University physicists Mathias Lösche and Frank Heinrich have established the structure of an important tumor suppressing protein, PTEN.
Major Innovation in Molecular Imaging Delivers Spatial and Spectral Info Simultaneously
Berkeley Lab scientist invents technique to combine spectroscopy with super-resolution microscopy, enabling new ways to examine cell structures and study diseases.
Helicobacter Pylori's Secret Weapon
Finding the molecular interactions that make this pathogen so successful in such a harsh environment has, until now, proved elusive.
Unprecedented Insights Into the Reactions Powering Fuel Cells
Nanotech-enabled chip developed at UCLA can analyze chemical reactions more accurately than large machines
Ultrafast Laser Pulses for Spectroscopy and Biomedical Applications
Graphene Flagship researchers have developed an optical fibre laser that emits pulses with durations equivalent to just a few wavelengths of the light used. This fastest ever laser based on graphene will be ideal for use in ultrafast spectroscopy, and in surgical lasers that avoid heat damage to living tissue.
Device May Detect Urinary Tract Infections Faster
A Lab-on-a-Disc platform developed by a German and Irish team of researchers dramatically cut the time to detect bacterial species that cause urinary tract infections -- a major cause of sepsis.
New Hybrid Microscope Offers Unparalleled Capabilities
A microscope being developed at the Department of Energy’s Oak Ridge National Laboratory will allow scientists studying biological and synthetic materials to simultaneously observe chemical and physical properties on and beneath the surface.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!