Corporate Banner
Satellite Banner
Spectroscopy
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Applications of Metabolomics in Cancer Research

Published: Monday, July 22, 2013
Last Updated: Monday, July 22, 2013
Bookmark and Share
This review focuses on specific areas within cancer and carcinogenesis research on which metabolomics has been brought to bear.

Abstract
The first discovery of metabolic changes in cancer occurred almost a century ago. While the genetic underpinnings of cancer have dominated its study since then, altered metabolism has recently been acknowledged as a key hallmark of cancer and metabolism-focused research has received renewed attention. The emerging field of metabolomics - which attempts to profile all metabolites within a cell or biological system - is now being used to analyze cancer metabolism on a system-wide scale, painting a broad picture of the altered pathways and their interactions with each other. While a large fraction of cancer metabolomics research is focused on finding diagnostic biomarkers, metabolomics is also being used to obtain more fundamental mechanistic insight into cancer and carcinogenesis. Applications of metabolomics are also emerging in areas such as tumor staging and assessment of treatment efficacy. This review summarizes contributions that metabolomics has made in cancer research and presents the current challenges and potential future directions within the field.

The article is published online in the Journal of Carcinogenesis and is free to access.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Role of Water in Chromosome Spreading and Swelling Induced by Acetic Acid Treatment
Researchers analysed intact lymphocytes before and at each stage of the chromosome preparation protocol by FTIR spectroscopy.
Thursday, June 12, 2014
Diagnosis of Bladder Cancer and Prediction of Survival by Urinary Metabolomics
Bladder cancer seems to be ideal for urinary metabolomics-based diagnosis, as urine can directly contact the cancer lesion in the bladder.
Tuesday, April 22, 2014
A Metabolomic Perspective on Coeliac Disease
Metabolomics has proved to be a useful complement for the characterization of several physiological and pathological conditions and offers promises as a clinical tool.
Monday, April 07, 2014
Evaluation of Thermally Degraded Vegetable Oils using FTIR and GCMS
Researchers report a synchronised signal processing algorithm that caters both FTIR and GCMS signal for evaluation of thermally degraded vegetable oils.
Tuesday, March 11, 2014
FTIR Spectroscopy as a Method to Study Lipid Accumulation in Oleaginous Yeasts
The absorption spectra allows monitoring of the progression of fatty acid accumulation and identification of the most represented classes of the produced lipids.
Tuesday, February 11, 2014
Metabolomics as a Diagnostic Tool in Gastroenterology
This review summarizes contributions that metabolomics has made in IBD and IBS and presents potential future directions within the field.
Thursday, December 12, 2013
Rapid Quantification of Methamphetamine: Using ATR-FTIR and Chemometrics
Researchers have developed novel, robust methods using ATR-FTIR and partial least squares as rapid and inexpensive alternatives to the current UPLC-UV method of methamphetamine quantification.
Wednesday, November 13, 2013
Structural Characterization of Intrinsically Disordered Proteins by NMR Spectroscopy
This review article addresses both NMR experiments and strategies that yield data which can be used for the generation of detailed structural models of IDPs as well as in-cell NMR.
Friday, September 20, 2013
Detection of Gastric Cancer with FTIR Spectroscopy and Support Vector Machine Classification
Research indicates that FT-IR spectroscopy with chemometrics method is reliable, practical, and could be easily implemented in gastric cancer diagnosis.
Friday, September 20, 2013
Effect of Trans Fatty Acid Intake on LC-MS and NMR Plasma Profiles
In this study, NMR and LC-MS untargeted metabolomics has been used as an approach to explore the impact of trans fatty acid intake on plasma metabolites.
Tuesday, August 13, 2013
1H NMR Spectroscopic Quantification of Plasma Metabolites in Dialysate during Hemodialysis
Researchers from Tohoku University have examined the feasibility of using TSP as a quantitative standard of dialysate.
Thursday, May 16, 2013
Use of FT-IR Spectra and PCA to the Bulk Characterization of Cell Wall Residues of Fruits and Vegetables Along a Fraction Process
The study has demonstrated that discrimination between the cell wall residues of fruits and vegetables is possible with the use of FT-IR spectra analysed using the PCA method.
Thursday, May 16, 2013
Triple Resonance Three-Dimensional Protein NMR: Before it Became a Black Box
This account provides a personal perspective on three-dimensional triple resonance experiments, providing some historical background.
Monday, April 29, 2013
Raman Microspectroscopy as a Biomarking Tool for In Vitro Diagnosis of Cancer: A Feasibility Study
The potential of Raman and infrared spectroscopy to become complementary to standard histology has recently intensified.
Monday, February 18, 2013
Crowding, Molecular Volume and Plasticity: An Assessment Involving Crystallography, NMR and Simulations
It is suggested that crowding leads to compaction of protein structure and influences the functionally important plasticity of the molecule.
Wednesday, December 05, 2012
Scientific News
Using Light To Examine The Lungs Of Premature Babies
New technique has potential to replace the use of X-rays to see how much air babies’ lungs contain.
Novel Spectroscopy by Using Aberrations
Flaws inherent to electron microscopy used to create probes for performing novel atomic-level spectroscopy.
Effective Identification of Low-Gliadin Wheat Lines
Researchers have demonstrated the use of NIRS to identify low-gliadin wheat lines.
Prostate Cancer Surgery Improved
Researchers at UT Southwestern Medical Center have determined that light reflectance spectroscopy can differentiate between malignant and benign prostate tissue with 85 percent accuracy, a finding that may lead to real-time tissue analysis during prostate cancer surgery.
Faster UVA Molecular Analysis Technology
There are people in the world – chemical engineers, astronomers, national defense scientists investigating an explosion – who need to know just what something is made of, down to the molecular level.
Properties of Light Can be Controlled by Nanostructures
A study led by the UPV/EHU-University of the Basque Country professor Ángel Rubio has simulated a new device to generate terahertz radiation using carbon nanostructures.
Infrared Spectrometer ‘Engine’ for Developers
Si-Ware Systems has launched volume production of the smallest, lowest-cost infra-red spectrometer “engine” for developers.
Breaking the Chain
Compound prevents multidrug-resistant fungi from pumping out drugs.
Low-Cost, Portable NQR Spectroscopy
A researcher at Case Western Reserve University is developing a low-cost, portable prototype designed to detect tainted medicines and food supplements that otherwise can make their way to consumers. The technology can authenticate good medicines and supplements.
Structure of Brain Plaques in Huntington's
Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!