Corporate Banner
Satellite Banner
Spectroscopy
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Component-Specific Particle Characterization of Pharmaceutical Cream

Published: Wednesday, January 29, 2014
Last Updated: Wednesday, January 29, 2014
Bookmark and Share
Publication shows use of Morphologi G3-ID for component-specific particle characterization of pharmaceutical cream.

The application of morphologically directed Raman spectroscopy to characterizing the component-specific particulate properties of the active components in a topical pharmaceutical cream is described in an application note from Malvern Instruments.

While it is relatively straightforward to determine the particle size distributions of the individual components of a drug formulation before they are formulated as a blend, doing so post-blending is more challenging.

Now, the Morphologi G3-ID, which combines automated image analysis with Raman spectroscopy in a single instrument, enables component-specific particle size and shape distributions to be obtained from a blend. The results of this analysis can provide information about the homogeneity and potency of individual components.

Such insight is helpful in improving product understanding and can be applied from a regulatory perspective right through to troubleshooting and optimizing manufacturing processes.

‘Component specific particle characterization of active component(s) in topical cream products’ is freely downloadable from the Malvern website. It details the analysis of a commercially available topical cream containing two active ingredients. These two morphologically similar actives could not be differentiated by image analysis alone, however the combination of image analysis with Raman spectroscopy allowed the unambiguous determination of particle size distribution for each component. To download the application note go to http://www.malvern.com/topical-formulations-g3id.

The Morphologi G3-ID provides size, shape and chemical analysis information for particles in the size range 0.5 µm - 1000 µm for a variety of sample types, including dry powders, liquids and creams. It operates by scanning a particle dispersion and using advanced optics to capture images of individual particles.

The system then automatically selects particles within the dispersion and collects a Raman spectrum from each one, allowing them to be classified and grouped in terms of discrete component populations. Designed for operational ease of use, the fully automated instrument enables particle characterization scientists with even limited spectroscopic experience to gain an in-depth understanding of their particulate samples.

To find out more about the growing range of Morphologi G3-ID applications or to explore the range of Malvern particle characterization solutions visit http://www.malvern.com/labeng/products/morphologi/raman.htm.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Malvern Instruments Experts win Industry Poster Award at DDL21
Deborah Huck, Malvern’s Product Technical Specialist for imaging, and co-authors have been awarded the industry poster award for, "Characterizing a Nasal Spray Formulation from Droplet to API Particle Size" at this year’s Drug Delivery to the Lungs conference (DDL21).
Thursday, December 16, 2010
Scientific News
Hunting the Missing Link Between Genetics and the Environment
The International Phenome Centre Network (IPCN) works to transform healthcare through phenomics - the dynamic interactions between our genes and our environment.
Chemical Snapshots Could Lead to Better Engineered Cartilage
Taking "chemical photographs" of the cartilage between joints and comparing it to engineered versions could lead to better implants, say researchers.
Identifying Functional Biomarkers of Traumatic Brain Injury
In this study, prefrontal hemodynamic biomarkers were identified that can distinguish traumatic brain injury patients from healthy subjects.
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
Identification of Individual Red Blood Cells by Raman Microspectroscopy
In this study, Raman Microspectroscopy was used to identify individual red blood cells.
The Power Of Orthogonality In Assessing The Stability Of Biopharmaceuticals
By utilizing orthogonal techniques, researchers can maximize the secure application of all analytical results generated.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Curcumin Shows Promise as Cancer Treatment
When delivered at the correct circadian phase, curcumin demonstrates sustained toxicity in cancer cells and should be considered for use in patient care.
Using the Linkam THMS600 Temperature Stage to Study Fluid Inclusions
The University of Lyon use the Linkam THMS600 temperature stage for the study of Brillouin spectroscopy of fluid inclusions.
Guided Needles Hit the Mark
New sensor could help anesthesiologists place needles for epidurals and other medical procedures.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!