Corporate Banner
Satellite Banner
Spectroscopy
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Component-Specific Particle Characterization of Pharmaceutical Cream

Published: Wednesday, January 29, 2014
Last Updated: Wednesday, January 29, 2014
Bookmark and Share
Publication shows use of Morphologi G3-ID for component-specific particle characterization of pharmaceutical cream.

The application of morphologically directed Raman spectroscopy to characterizing the component-specific particulate properties of the active components in a topical pharmaceutical cream is described in an application note from Malvern Instruments.

While it is relatively straightforward to determine the particle size distributions of the individual components of a drug formulation before they are formulated as a blend, doing so post-blending is more challenging.

Now, the Morphologi G3-ID, which combines automated image analysis with Raman spectroscopy in a single instrument, enables component-specific particle size and shape distributions to be obtained from a blend. The results of this analysis can provide information about the homogeneity and potency of individual components.

Such insight is helpful in improving product understanding and can be applied from a regulatory perspective right through to troubleshooting and optimizing manufacturing processes.

‘Component specific particle characterization of active component(s) in topical cream products’ is freely downloadable from the Malvern website. It details the analysis of a commercially available topical cream containing two active ingredients. These two morphologically similar actives could not be differentiated by image analysis alone, however the combination of image analysis with Raman spectroscopy allowed the unambiguous determination of particle size distribution for each component. To download the application note go to http://www.malvern.com/topical-formulations-g3id.

The Morphologi G3-ID provides size, shape and chemical analysis information for particles in the size range 0.5 µm - 1000 µm for a variety of sample types, including dry powders, liquids and creams. It operates by scanning a particle dispersion and using advanced optics to capture images of individual particles.

The system then automatically selects particles within the dispersion and collects a Raman spectrum from each one, allowing them to be classified and grouped in terms of discrete component populations. Designed for operational ease of use, the fully automated instrument enables particle characterization scientists with even limited spectroscopic experience to gain an in-depth understanding of their particulate samples.

To find out more about the growing range of Morphologi G3-ID applications or to explore the range of Malvern particle characterization solutions visit http://www.malvern.com/labeng/products/morphologi/raman.htm.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Malvern Instruments Experts win Industry Poster Award at DDL21
Deborah Huck, Malvern’s Product Technical Specialist for imaging, and co-authors have been awarded the industry poster award for, "Characterizing a Nasal Spray Formulation from Droplet to API Particle Size" at this year’s Drug Delivery to the Lungs conference (DDL21).
Thursday, December 16, 2010
Scientific News
A Highly Sensitive Graphene Based Sensor
Researchers at EPFL and ICFO have developed a sensor made from graphene to detect molecules such as proteins and drugs.
Cannabis May Be Used to Treat Fractures
TAU researcher finds non-psychotropic compound in marijuana can help heal bone fissures.
Researchers Reveal Elusive Molecule
A long-standing chemistry puzzle has been solved, with potential implications ranging from industrial processes to atmospheric chemistry.
Optical 'Dog's Nose' Developed to Detect Cancer, Other Diseases
Researchers are using optical spectroscopy to develop a quick, non-invasive “breath test” they believe will have the potential to screen for a variety of diseases, including diabetes, infections and cancers.
Unravelling the Mysteries of Carbonic Acid
Researchers have shown how gaseous carbon dioxide molecules are solvated by water to initiate the proton transfer chemistry that produces carbonic acid and bicarbonate.
NIR Spectroscopy Produces a Handy Image of Blood Circulation
Poor blood circulation can be revealed by a novel form of near infrared (NIR) spectroscopy, say Italian medical researchers.
Combination Imaging Reveals Fuel Cell Damage
A simultaneous view of both chemical distribution and bonding states in fuel cell membranes shows how and where irreversible degradation takes place.
Shining A New Light On The Immune System
Scientists at the University of St Andrews have developed a revolutionary method of identifying cells of the immune system with “molecular fingerprints” which could pave the way for the rapid detection of conditions such as leukaemia and lymphoma from a small blood sample.
Holes in Gold Enhance Molecular Sensing
Electrochemical techniques produce tuneable porous gold films, where the empty spaces enhance light scattering and sensing signals.
Damming hemorrhagic diseases
A potential mechanism to combat diseases caused by haemorrhagic fever viruses has been discovered by researchers.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!