Corporate Banner
Satellite Banner
Spectroscopy
Scientific Community
 
Join | Sign in
Home>Videos>This Video
  Videos

Return

Towards the Systematic Exploration of Chemical Space: Design, Synthesis and Exploitation of Diverse Small Molecular Libraries
SelectBio

Our knowledge of the biological relevance of chemical space is based, to a large extent, on its historical exploration by synthesis (and biosynthesis). However, chemists’ exploration of chemical space has been uneven and unsystematic: the known organic chemistry ‘universe’ is dominated by a small number of scaffolds that are found in a large number of small molecules. Developing synthetic approaches that allow broad tracts of chemical space to be explored has proved extremely challenging. This presentation will describe synthetic approaches that enable the preparation of libraries of diverse small molecules. Methods which allow the systematic variation of ligand scaffold are particularly rare, and the scaffold diversity of chemical libraries does not approach that of natural products. One of the synthetic approaches that will be described has yielded a small molecule library of unprecedented skeletal diversity. Remarkably, it possible that the approach might address the synthetic problems associated with each of the stages of ligand discovery.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
Distinguishing Normal From Cancerous Tissue
FAU study demonstrates a potentially faster and more accurate mode of cancer treatment with new laser technology.
Bacterial Memories – Host influences Bacterial Metabolism
Study shows bacteria have some sort of memory.
Reaction Monitoring Research Using the Spinsolve Benchtop NMR System
Reaction monitoring studies in the Cronin Group in the Chemistry Department of the University of Glasgow.
Revolutionary New Probe Zooms In On Cancer Cells
Improves tumour surgeries and extends survival times for brain cancer patients.
New Discoveries In Primary Pathway for Neurological Diseases
Discovery could lead to new drug design for neurodegenerative diseases.
Fingerprints Taken From Golden Eagle Feathers
First tried and tested method to recover fingerprints from feathers and eggs of birds of prey is developed.
Stanford Chemists Take Step Toward Solving Mystery of How Enzymes Work
Steven Boxer and his students have found that the electrostatic field within an enzyme accounts for the lion's share of its success.
Raman Spectroscopy May Enable Non-Invasive Diagnosis of Bone Diseases
Detection of a genetic ‘brittle bone’ disease known as Osteogenesis Imperfecta (OI) is possible by simply scanning a patient’s limbs.
New Test For Detecting Horse Meat
New test compares differences in chemical compositions of the fat found in meats.
Turkeys may be Lifesavers
Antibiotic to target staph infections, strep, comes from good bacteria in turkeys.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters