Corporate Banner
Satellite Banner
Technology Networks Header
Saturday, October 25, 2014
Technology Networks
 
Register | Sign in
Home Page > Videos > Conformational Changes Induced by Nanomaterials: Functional Implications
  Videos

Return

Conformational Changes Induced by Nanomaterials: Functional Implications
SELECTBIO

The interaction of nanoparticles with body fluids may induce conformational changes in the proteins present in the medium. Such interactions could induce functional loss or important modifications in some proteins, and trigger cellular events induced by the NP-protein moiety. As metal oxide nanoparticles are widely used for various applications, the interaction of four different metal oxide nanoparticles (ZnO, TiO2, CeO2 and Al2O3) with three of the main protein fractions from human plasma (albumin, fibrinogen and globulins) was characterized by fluorescence and Fourier-transform infrared (FTIR) spectroscopy. The pattern of nanoparticle-protein interaction was shown to vary from a strong interaction with ZnO nanoparticles, which induced a decrease in the thermal stability of fibrinogen and albumin at a low temperature, and interferes with the clotting of fibrinogen, to a slight or null interaction with Al2O3 nanoparticles at physiological pH. The influence of pH was also characterized for albumin, with the interaction showing an important dependence on the surface charge of the nanoparticles. Metal oxide nanoparticles induced conformational changes in the secondary structure of albumin, principally the transformation of α-helices into β-sheet structures. This interaction, with the exception of Al2O3 nanoparticles at basic pH, could take place in domain II of the protein, formed mainly by hydrophobic and positive residues.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
New Catalyst could Improve Production of Biofuels
Washington State University researchers have developed a new catalyst that could lead to making biofuels cheaply and more efficiently.
A Molecular Physics Experience Through Movement at Stanford
dS, short for danceroom Spectroscopy, is the world's first large-scale, interactive molecular physics experience.
Watching Molecules ‘Dance’ in Real Time
Trapping light at the nanoscale enables real-time monitoring of individual molecules bending and flexing may aid in our understanding of how changes within a cell can lead to diseases such as cancer.
How to Prevent Organic Food Fraud
A new test under development has the potential to authenticate organic tomatoes and other produce.
3-in-1 Spectroscopy System Improves Skin Cancer Detection
The new device may detect cancerous skin lesions early on, leading to better treatment outcomes and ultimately saving lives.
Minuscule Chips for NMR Spectroscopy Promise Portability, Parallelization
Two-by-two-millimeter spectrometer dramatically shrinks footprint for multidimensional analysis of molecules.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
New Spectroscopy Technique Provides Unprecedented Look into Photochemical Reactions
Two-dimensional electronic-vibrational spectroscopy can be used to simultaneously monitor electronic and molecular dynamics on a femtosecond time-scale.
X-rays Used to Examine How DNA Protects Itself from UV Light
Scientists have made detailed observations of a “relaxation response” that protects these molecules, and the genetic information they encode, from UV damage.
Using Spectroscopy to Diagnose Skin Cancer
Autofluorescence and diffuse reflectance spectroscopy identify malignant melanoma with 93% accuracy.
Scroll Up
Scroll Down
Skyscraper Banner
Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv