 |  |  |
|
|
 | Differences Between Old and Young Mesenchymal Stem Cells for Drug Metabolism Andreas Nuessler, Eberhard-Karls University Tübingen, speaking at Stem Cells & Bioprocessing Europe 2012. |
 | SUT Applications in Up – and Downstream Bioprocessing Professor Manuel Carrondo, University Nova de Lisboa, speaking at Stem Cells & Bioprocessing Europe 2012. |
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Cellular Therapy and Cord Blood 2013 Market Report
Select Biosciences Ltd
This is the most up-to-date market report focusing on Cellular Therapy and the HSCT/Cord Blood Market Landscape, published by Select Biosciences.
Stem Cells in Research & Drug Discovery Trends 2012
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on stem cells in research and drug discovery carried out in November 2012.
Stem Cell Research in Cardiology
RI Technologies
This market insight report on Stem Cell Research in Cardiology emphasizes on the market for stem cells in Cardiology. The study is segmented by Source (Allogenic and Autogenic) and by Type (Bone Marrow Stem Cells, Embryonic Stem Cells, and Other).
Stem Cell Research
RI Technologies
This report on Stem Cell Research gives a market insight into the ever progressing and debatable market of Stem Cell Research segmented by type, technology and therapeutic area.
Biobanks - 2012 Year Book
GBI Research
The report provides information on population-based biobanks, disease based biobanks, brain biobanks, stem cell biobanking, twin registries, children biobanks and many national biobanks. It also provides comprehensive analysis of funding, harmonization, the cost of biobanking, and partnership structure. In addition, the report reviews the factors determining the success and failure of biobanks.
Stem Cell Research in India 2012
Netscribes
The stem cell research in India is in its nascent stage and is gradually on a growth path of acceptance by people. The market is still in a phase of conducting research to establish itself as one of the best therapies for the widely prevalent incurable lifestyle diseases. Awareness campaigns and doctors are playing a key role educating people and especially would-be parents about the benefits associated with preserving stem cells.
Cord Blood, Embryonic and Adult Stem Cells Applications & Technologies - A Global Market Watch, 2009-2015
Axis Research Mind
The report reviews the latest stem cells market trends with a perceptive to disclose the near-future growth prospects. An in-depth analysis across the geographic regions provides strategic business intelligence for life science and as well as healthcare sector investments.
Cryopreservation Equipments in Stem Cells - A Global Market Watch, 2009-2015
Axis Research Mind
The report reviews the latest trends in cryopreservation equipments used in stem cells technology with a perceptive to disclose the near-future growth prospects in cryopreservation of stem cells.
Stem Cell Research Market to 2017
GBI Research
Strong Pipeline, High Unmet Needs in Chronic Diseases and Favorable Government Policies to Boost Stem Cell R&D
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Cellular Therapy and Cord Blood 2013 Market Report
Select Biosciences Ltd
This is the most up-to-date market report focusing on Cellular Therapy and the HSCT/Cord Blood Market Landscape, published by Select Biosciences.
Stem Cells in Research & Drug Discovery Trends 2012
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on stem cells in research and drug discovery carried out in November 2012.
Stem Cell Research in Cardiology
RI Technologies
This market insight report on Stem Cell Research in Cardiology emphasizes on the market for stem cells in Cardiology. The study is segmented by Source (Allogenic and Autogenic) and by Type (Bone Marrow Stem Cells, Embryonic Stem Cells, and Other).
Stem Cell Research
RI Technologies
This report on Stem Cell Research gives a market insight into the ever progressing and debatable market of Stem Cell Research segmented by type, technology and therapeutic area.
Biobanks - 2012 Year Book
GBI Research
The report provides information on population-based biobanks, disease based biobanks, brain biobanks, stem cell biobanking, twin registries, children biobanks and many national biobanks. It also provides comprehensive analysis of funding, harmonization, the cost of biobanking, and partnership structure. In addition, the report reviews the factors determining the success and failure of biobanks.
Stem Cell Research in India 2012
Netscribes
The stem cell research in India is in its nascent stage and is gradually on a growth path of acceptance by people. The market is still in a phase of conducting research to establish itself as one of the best therapies for the widely prevalent incurable lifestyle diseases. Awareness campaigns and doctors are playing a key role educating people and especially would-be parents about the benefits associated with preserving stem cells.
Cord Blood, Embryonic and Adult Stem Cells Applications & Technologies - A Global Market Watch, 2009-2015
Axis Research Mind
The report reviews the latest stem cells market trends with a perceptive to disclose the near-future growth prospects. An in-depth analysis across the geographic regions provides strategic business intelligence for life science and as well as healthcare sector investments.
Cryopreservation Equipments in Stem Cells - A Global Market Watch, 2009-2015
Axis Research Mind
The report reviews the latest trends in cryopreservation equipments used in stem cells technology with a perceptive to disclose the near-future growth prospects in cryopreservation of stem cells.
Stem Cell Research Market to 2017
GBI Research
Strong Pipeline, High Unmet Needs in Chronic Diseases and Favorable Government Policies to Boost Stem Cell R&D
Program for Breakthrough Biomedical Research to Celebrate 15 Years
A program that fosters basic science projects of potentially high impact is celebrating 15 years of discovery at UC San Francisco.
UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice
Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
Team Successfully Converts Human Skin Cells into Embryonic Stem Cells
The breakthrough marks the first time human stem cells have been produced via nuclear transfer and follows several unsuccessful attempts by research groups worldwide.
Nobel Prize Rockets Stem Cell Program to New Heights
Shinya Yamanaka's Feat Brings fresh attention to promise of regeneration medicine.
Cobra Biologics and Vaccibody Sign Agreement to Manufacture DNA Vaccine
Companies announce agreement to manufacture Vaccibody’s lead DNA vaccine candidate against HPV-induced malignancies.
Stem Cells Show Promise for Treating Rare Nerve Disease
Scientists have used iPS cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia (A-T).
Two MIT Professors Named Howard Hughes Medical Institute Investigators
Peter Reddien and Aviv Regev are among 27 top biomedical scientists selected nationwide.
Cell Therapy Promise Highlighted at UCSF Symposium
Old-line pharmaceutical companies and maturing biotech businesses both are graybeards compared to newer ventures focused on cell therapy.
Researchers Chart Epigenomics of Stem Cells That Mimic Early Human Development
Collaborative study will help overcome hurdles to using stem cells to treat diseases and injuries.
NYSCF Scientists Create Personalized Bone Substitutes from Skin Cells
For treatment of large bone defects and traumatic injuries.
A program that fosters basic science projects of potentially high impact is celebrating 15 years of discovery at UC San Francisco.
UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice
Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
Team Successfully Converts Human Skin Cells into Embryonic Stem Cells
The breakthrough marks the first time human stem cells have been produced via nuclear transfer and follows several unsuccessful attempts by research groups worldwide.
Nobel Prize Rockets Stem Cell Program to New Heights
Shinya Yamanaka's Feat Brings fresh attention to promise of regeneration medicine.
Cobra Biologics and Vaccibody Sign Agreement to Manufacture DNA Vaccine
Companies announce agreement to manufacture Vaccibody’s lead DNA vaccine candidate against HPV-induced malignancies.
Stem Cells Show Promise for Treating Rare Nerve Disease
Scientists have used iPS cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia (A-T).
Two MIT Professors Named Howard Hughes Medical Institute Investigators
Peter Reddien and Aviv Regev are among 27 top biomedical scientists selected nationwide.
Cell Therapy Promise Highlighted at UCSF Symposium
Old-line pharmaceutical companies and maturing biotech businesses both are graybeards compared to newer ventures focused on cell therapy.
Researchers Chart Epigenomics of Stem Cells That Mimic Early Human Development
Collaborative study will help overcome hurdles to using stem cells to treat diseases and injuries.
NYSCF Scientists Create Personalized Bone Substitutes from Skin Cells
For treatment of large bone defects and traumatic injuries.
Qatar Biobank Builds Momentum
Qatar Biobank recently welcomed its 300th participant through the doors of its centre in Hamad Medical City.
Cell Therapy Catapult to work with GSK on Cell Therapies
First partnership with large pharma company for Cell Therapy Catapult.
UK-Norwegian Collaboration Aims to Develop a New Living Skin Equivalent Model
New in vitro human living skin equivalent model for testing inflammatory responses.
FDA Agreement on Mesoblast’s Use of Singapore Manufacturing Facility for MPCs Clinical Trial Production
New facility will support product delineation strategies, increase geographical reach, and reduce risk of single site reliance.
Mesoblast Receives FDA Clearance for Phase 2 Trial of MPCs in Active RA Patients
In addition, a second Phase 2 trial of MPCs as a first-line biologic treatment for active RA is planned to commence in Europe in 1H 2013.
NanoKTN Supports Regenerative Medicine Development
UK Regenerative Medicine Platform (UKRMP) Safety Hub announced.
RTG and JCVI Embark on Strategic Research Initiative
Long-term collaboration to understand de novo mutations for stem cell progression study and deliver validated, gold-standard datasets.
InVivo Therapeutics Named a 2013 “Best Places to Work” Winner by Boston Business Journal
Company has been named one of the Best Places to Work in Massachusetts by the The Boston Business Journal in its eleventh annual regional awards program.
STEMCELL Technologies Inc. Obtains License from iPS Academia Japan for Induced Pluripotent Stem Cell Technologies
The agreement will enable STEMCELL Technologies to develop media that are optimized for cellular reprogramming.
ViaCord® Collaborates with the Center for International Blood and Marrow Transplant Research®
PerkinElmer’s family cord blood banking business and international research organization collaborates to analyze quality and outcomes of cord blood stem cell units.
Qatar Biobank recently welcomed its 300th participant through the doors of its centre in Hamad Medical City.
Cell Therapy Catapult to work with GSK on Cell Therapies
First partnership with large pharma company for Cell Therapy Catapult.
UK-Norwegian Collaboration Aims to Develop a New Living Skin Equivalent Model
New in vitro human living skin equivalent model for testing inflammatory responses.
FDA Agreement on Mesoblast’s Use of Singapore Manufacturing Facility for MPCs Clinical Trial Production
New facility will support product delineation strategies, increase geographical reach, and reduce risk of single site reliance.
Mesoblast Receives FDA Clearance for Phase 2 Trial of MPCs in Active RA Patients
In addition, a second Phase 2 trial of MPCs as a first-line biologic treatment for active RA is planned to commence in Europe in 1H 2013.
NanoKTN Supports Regenerative Medicine Development
UK Regenerative Medicine Platform (UKRMP) Safety Hub announced.
RTG and JCVI Embark on Strategic Research Initiative
Long-term collaboration to understand de novo mutations for stem cell progression study and deliver validated, gold-standard datasets.
InVivo Therapeutics Named a 2013 “Best Places to Work” Winner by Boston Business Journal
Company has been named one of the Best Places to Work in Massachusetts by the The Boston Business Journal in its eleventh annual regional awards program.
STEMCELL Technologies Inc. Obtains License from iPS Academia Japan for Induced Pluripotent Stem Cell Technologies
The agreement will enable STEMCELL Technologies to develop media that are optimized for cellular reprogramming.
ViaCord® Collaborates with the Center for International Blood and Marrow Transplant Research®
PerkinElmer’s family cord blood banking business and international research organization collaborates to analyze quality and outcomes of cord blood stem cell units.
 | ||||||||||||||||
|
Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech 2012
Chang Gung University
Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech 2012
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.
Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
ISMTR-283 Protects Human Bone Marrow Progenitors from the Lethal Effects of Ionizing Radiation
ReachBio LLC
Bone Marrow (BM) is extremely susceptible to radiation damage. BM from matched donors is often used to ‘rescue’ patients following medical radiation for leukemia. However, in the event of accidental/environmental radiation exposure, the ability to identify appropriate donors in a timely manner is rarely possible. Using CFC assays, we evaluated a small molecule compound (ISMTR-283) for its potential to protect the marrow progenitor cells and microenvironment from radiation damage.
Analyzing Molecular Polar Surface Descriptors to Predict Blood-Brain Barrier Permeation
University of Würzburg
Permeation of active drugs across the vascular brain endothelium into the central nervous system (CNS) is controlled by the blood-brain barrier (BBB). Some molecular quantities like polar surface (PS) descriptors are of key interest to medicinal chemists to predict the BBB permeation fate for different drug-like chemical compounds.
The Mesenchymal Stem Cells Bioengineered Tissue Using Cobalt-60 Radiation
IPEN/CNEN - USP
The biological effects of gamma radiation by cobalt-60 sources on epidermal-dermal matrix have not been fully elucidated when mesenchymal stem cells cultured add in. This poster shows how scientists standardized the keratinocytes and adipose-derived stem cell (ADSC) culture procedure before constructing a bioengineered dermal-epidermal equivalent populated by keratinocytes and ADSC cultured cells.
Expression of Pluripotency-determining Factors in in vitro Fertilized Buffalo Embryos and Embryonic Stem Cells
Animal Biotechnology Centre, NDRI
The POU octamer-binding domain transcription factor Oct-4, Stage-specific embryonic antigens (SSEAs), and Tumor rejection antigens (TRAs), are developmentally regulated during early embryogenesis.
Effect of Culture Media and Serum Supplementation on the Development of in vitro Fertilized Buffalo Embryos
Central Institute for Research on Buffaloes
This poster compares the development of buffalo embryos in simple and complex culture media and aims to determine the effects of serum supplementation on the development of buffalo embryos.
High Content Analysis of Neural Stem Cell Expansion and Differentiation
Molecular Devices
Automated assay methods for monitoring neural stem cell expansion and differentiation using stem cell derived neural cell lines and high content imaging systems have been described.
Neurotoxicity Assays Using iPSC-Derived Neurons and High Content Imaging
Molecular Devices
Neurotoxicity can cause temporary or permanent damage of brain or peripheral nervous system and has been found to be a major cause of neurodegenerative diseases such as Alzheimer’s or Parkinson’s. Accordingly, there is a great interest in developing more predictive, disease relevant cell-based models and efficient screening tools for assessing the neurotoxicity of chemical compounds, drug candidates and environmental agents.
Live Cell Beating Assay Using Human iPSC-derived Cardiomyocytes for Evaluation of Drug Efficacy and Toxicity
Molecular Devices
A large percentage of new drugs fail in clinical studies due to cardiac toxicity. Development of highly predictive in vitro assays suitable for screening, safety assessment or other environments is therefore extremely important for drug development. Human cardiomyocytes derived from stem cell sources can greatly accelerate the discovery of cardiac drugs and improve drug safety by offering more clinically relevant cell-based models than those presently available.
Chang Gung University
Chia-Hsun Hsieh and Sanger Hung-Chih Lin win at CellTech 2012
Gene Expression from Pseudourine and 5-Methylcytidine Modified Messenger RNA
TriLink BioTechnologies, Inc.
Study objective was to develop methodologies for gram scale synthesis of messenger RNA (mRNA) for gene therapy applications, as well as scalable purification methods that yield highly expressed, persistent and non-toxic mRNA.
ISMTR-283 Protects Human Bone Marrow Progenitors from the Lethal Effects of Ionizing Radiation
ReachBio LLC
Bone Marrow (BM) is extremely susceptible to radiation damage. BM from matched donors is often used to ‘rescue’ patients following medical radiation for leukemia. However, in the event of accidental/environmental radiation exposure, the ability to identify appropriate donors in a timely manner is rarely possible. Using CFC assays, we evaluated a small molecule compound (ISMTR-283) for its potential to protect the marrow progenitor cells and microenvironment from radiation damage.
Analyzing Molecular Polar Surface Descriptors to Predict Blood-Brain Barrier Permeation
University of Würzburg
Permeation of active drugs across the vascular brain endothelium into the central nervous system (CNS) is controlled by the blood-brain barrier (BBB). Some molecular quantities like polar surface (PS) descriptors are of key interest to medicinal chemists to predict the BBB permeation fate for different drug-like chemical compounds.
The Mesenchymal Stem Cells Bioengineered Tissue Using Cobalt-60 Radiation
IPEN/CNEN - USP
The biological effects of gamma radiation by cobalt-60 sources on epidermal-dermal matrix have not been fully elucidated when mesenchymal stem cells cultured add in. This poster shows how scientists standardized the keratinocytes and adipose-derived stem cell (ADSC) culture procedure before constructing a bioengineered dermal-epidermal equivalent populated by keratinocytes and ADSC cultured cells.
Expression of Pluripotency-determining Factors in in vitro Fertilized Buffalo Embryos and Embryonic Stem Cells
Animal Biotechnology Centre, NDRI
The POU octamer-binding domain transcription factor Oct-4, Stage-specific embryonic antigens (SSEAs), and Tumor rejection antigens (TRAs), are developmentally regulated during early embryogenesis.
Effect of Culture Media and Serum Supplementation on the Development of in vitro Fertilized Buffalo Embryos
Central Institute for Research on Buffaloes
This poster compares the development of buffalo embryos in simple and complex culture media and aims to determine the effects of serum supplementation on the development of buffalo embryos.
High Content Analysis of Neural Stem Cell Expansion and Differentiation
Molecular Devices
Automated assay methods for monitoring neural stem cell expansion and differentiation using stem cell derived neural cell lines and high content imaging systems have been described.
Neurotoxicity Assays Using iPSC-Derived Neurons and High Content Imaging
Molecular Devices
Neurotoxicity can cause temporary or permanent damage of brain or peripheral nervous system and has been found to be a major cause of neurodegenerative diseases such as Alzheimer’s or Parkinson’s. Accordingly, there is a great interest in developing more predictive, disease relevant cell-based models and efficient screening tools for assessing the neurotoxicity of chemical compounds, drug candidates and environmental agents.
Live Cell Beating Assay Using Human iPSC-derived Cardiomyocytes for Evaluation of Drug Efficacy and Toxicity
Molecular Devices
A large percentage of new drugs fail in clinical studies due to cardiac toxicity. Development of highly predictive in vitro assays suitable for screening, safety assessment or other environments is therefore extremely important for drug development. Human cardiomyocytes derived from stem cell sources can greatly accelerate the discovery of cardiac drugs and improve drug safety by offering more clinically relevant cell-based models than those presently available.
Analyzing Biological Samples
Tecan
This technical note describes the capability of Tecan’s Infinite® 200 PRO multimode reader to regulate the CO2 partial pressure inside its measurement chamber.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Sample Reformatting and Sample Archiving
FluidX
Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
FluidX
With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.
Isolation and Characterization of Human Bone-Marrow-Derived Mesenchymal Stem Cells
Millipore
Mesenchymal stem cells derived from bone marrow have become an attractive model cell system for the in vitro and in vivo study of disease states such as osteoporosis, obesity, and arthritis. We have isolated mesenchymal stem cells (MSCs) from the bone marrow aspirate of a single human donor. Human bone-marrow-derived MSCs express the mesenchymal stem cell markers STR0-1, CD44, and CD90, and do not express hematopoietic markers CD14 and CD19. Human bone-marrow-derived MSCs can be expanded for 18
Stem Cell-Derived Human Neurons in CNS Drug Discovery
Molecular Devices
Central nervous system (CNS) disorders affect many people worldwide. To increase the quality and number of drugs available for treatments of CNS disorders such as Alzheimer’s disease, schizophrenia and anxiety, the success rate of CNS drug discovery programs must be improved. The challenge in drug discovery is to develop more relevant assay systems to identify lead compounds for further development. Cell-based screening assays currently used for CNS drug discovery and development involve primary
Nucleofection® of mouse ES cells
Amaxa GMBH
Efficient delivery of DNA is crucial for gene targeting in embryonic stem cells and for successful generation of knock-out mice. Data presented in this technote show that Nucleofection® leads to a homogenous gene expression pattern in mouse ES cell colonies. In contrast to standard electroporation, Nucleofection® results in a 100% deletion of frt-flanked genes on both alleles. Viable and fertile mice were generated from transfected mouse ES cell clones.
Tecan
This technical note describes the capability of Tecan’s Infinite® 200 PRO multimode reader to regulate the CO2 partial pressure inside its measurement chamber.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices
The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Sample Reformatting and Sample Archiving
FluidX
Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
FluidX
With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.
Isolation and Characterization of Human Bone-Marrow-Derived Mesenchymal Stem Cells
Millipore
Mesenchymal stem cells derived from bone marrow have become an attractive model cell system for the in vitro and in vivo study of disease states such as osteoporosis, obesity, and arthritis. We have isolated mesenchymal stem cells (MSCs) from the bone marrow aspirate of a single human donor. Human bone-marrow-derived MSCs express the mesenchymal stem cell markers STR0-1, CD44, and CD90, and do not express hematopoietic markers CD14 and CD19. Human bone-marrow-derived MSCs can be expanded for 18
Stem Cell-Derived Human Neurons in CNS Drug Discovery
Molecular Devices
Central nervous system (CNS) disorders affect many people worldwide. To increase the quality and number of drugs available for treatments of CNS disorders such as Alzheimer’s disease, schizophrenia and anxiety, the success rate of CNS drug discovery programs must be improved. The challenge in drug discovery is to develop more relevant assay systems to identify lead compounds for further development. Cell-based screening assays currently used for CNS drug discovery and development involve primary
Nucleofection® of mouse ES cells
Amaxa GMBH
Efficient delivery of DNA is crucial for gene targeting in embryonic stem cells and for successful generation of knock-out mice. Data presented in this technote show that Nucleofection® leads to a homogenous gene expression pattern in mouse ES cell colonies. In contrast to standard electroporation, Nucleofection® results in a 100% deletion of frt-flanked genes on both alleles. Viable and fertile mice were generated from transfected mouse ES cell clones.
