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Webcasts
Developing Predictive Hepatocyte Models from Pluripotent Stem Cells
David Hay, Principal Investigator, MRC Centre for Regenerative Medicine, speaking at Stem Cells in Drug Discovery.
Practicalities of Automating Human Interaction with Robotic Cells
This webinar will look at the use of industrial robots in work cells where operators need to load and unload products from the robots working area and what safety preclusions and solutions are available.

Market Reports
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Cellular Therapy and Cord Blood 2013 Market Report
Select Biosciences Ltd

This is the most up-to-date market report focusing on Cellular Therapy and the HSCT/Cord Blood Market Landscape, published by Select Biosciences.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2012
Select Biosciences Ltd

In this report, we focus upon the biology of CTCs and CSCs as well as explore the inter-relationship between these cell types based upon molecular events. Also presented are research trends which are for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastatic mechanisms.
Circulating Tumor Cells (CTCs) Market Trends 2011
Select Biosciences Ltd

This is the latest and most up-to-date Market Report from Select Biosciences addressing the circulating tumor cells (CTCs) space. In this report, we focus upon the emerging marketplace for the isolation and study of CTCs, a potentially important tool for cancer diagnostics with special relevance to cancer metastasis and mechanisms thereof.
Umbilical Cord Blood Banking Market Trends 2011
Select Biosciences Ltd

This report focuses upon cord blood banking and provided quantitative market analysis of the space as it relates to the growth of the field, utilization trends of cord blood for different diseases in different countries of the world.
Single Cell Omics 2011
Select Biosciences Ltd

The single cell Omics revolution is the potential transformation of cellular heterogeneity from a source of noise to a source of new, as yet hidden discoveries.
Future Directions in Regenerative Medicine
Business Insights

This report covers the development of therapies to replace human cells or promote their regeneration: including cell therapies, tissue engineering, drugs, and medical devices. Each company profiled has at least one project in preclinical or Phase I study. Many also have later stage or launched products, which are covered briefly to illustrate the potential of the next generation of candidates.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights

This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Stem Cells for Cellular Therapy 2010 Market Report
Select Biosciences Ltd

This market report is focused on presenting the market characteristics of stem cells as they are currently impacting research in the cellular therapy space. Furthermore, this report also addresses an important market, namely that of Umbilical Cord Blood Banking.
Adult Stem Cells Market Trends 2011
Select Biosciences Ltd

This report is focussed upon adult stem cells (especially mesenchymal stem cells; MSCs) and their properties making them highly suited for the development of cellular therapeutics.
Scientific News
Heart Defect Prediction Technology Could Lead to Earlier, More Informed Treatment
Experimental method uses genetics-guided biomechanics, patient-specific stem cells.
Immune Cells Remember Their First Meal
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response – a discovery that may pave the way for new treatments for many human diseases.
Cancer Cells Coordinate to Form Roving Clusters
Rice University scientists identify ‘smoking gun’ in metastasis of hybrid cells.
Bio-Mimicry Method For Preparing & Labeling Stem Cells Developed
Method allows researchers to prepare mesenchymal stem cells and monitor them using MRI.
Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
New Bio-Glass Could Make it Possible to Re-Grow or Replace Cartilage
Researchers at Imperial College London have developed a material that can mimic cartilage and potentially encourage it to re-grow.
Stem Cell Advance Could Be Key Step Toward Treating Deadly Blood Diseases
UCLA scientists get closer to creating blood stem cells in the lab.
Harnessing Engineered Slippery Surfaces For Tissue Repair
A new method could facilitate the transfer of intact regenerating cell sheets from the culture dish to damaged tissues in patients.
Brazilian Zika Virus Strain Causes Birth Defects in Experimental Models
First direct experimental proof of causal effect, researchers say.
Stem Cell Gene Therapy For Fatal Childhood Disease Ready For Human Trial
A pioneering approach for Sanfilippo disease, a genetic condition for which there is no effective treatment, will now be trialled in humans.
Business News
DefiniGEN Raises £1.5M
Company has announced that the investment will be used to fund commercial launch of new pancreatic and lung stem cell products for drug discovery and regenerative medicine.
Islexa Formed to Develop Novel Technology to Treat Diabetes
UK technology has potential to bring islet transplant therapy to thousands of patients with type 1 diabetes.
BioLineRx, MaRS Innovation Sign Framework Collaboration Agreement
Collaboration aims to review innovative projects and assets of startup companies originating from MaRS members, in order to identify in-licensing, co-development or other partnering opportunities.
Seres, MSK Announces Agreement
Collaboration aims to develop microbiome therapeutics for hematopoietic stem cell transplantation and immuno-oncology treatment.
Record £16.9m for OxStem
One of the most ambitious Oxford spinouts to date is en route to becoming a powerhouse in age-related regenerative medicine, developing drugs which can treat cancer, neurodegenerative diseases, heart failure, macular degeneration and other major age-related conditions.
AbbVie to Acquire StemCentrx
Transaction valued at approximately $5.8 billion, with additional milestones payable upon successful completion of pre-determined clinical and regulatory achievements.
Plasticell Awarded the Queen’s Award for Enterprise in Innovation 2016
Plasticell is pleased to announce it has been awarded the 2016 Queen’s Award for Enterprise in Innovation.
Axol Appoints New Scientific Advisory Board Member
Renowned neurodegenerative disease pioneer, Steve Finkbeiner joins the stem cell disease model specialists.
Promethera Acquires Cytonet Assets
Move creates global leader in regenerative medicine and cell therapy for liver diseases.
Cell and Gene Therapy Catapult, UCLB and Imperial Innovations Announce Positive Interim Review
The Cell and Gene Therapy Catapult alongside UCL Business PLC (UCLB) and Imperial Innovations, has announced a positive interim review in the phase I/II trial conducted by Catapult Therapy TCR using a T cell therapy to target acute myeloid leukaemia (AML).

Events
EMBL Conference: Hematopoletic
03 Jun 2016
EMBL Conference: Hematopoletic ...
EMBL Partnership Conference: P
06 Jun 2016
EMBL Partnership Conference: P ...
Germline Stem Cells Conference
19 Jun 2016
Germline Stem Cells Conference ...
9th China Bioindustry Conventi
05 Jul 2016
9th China Bioindustry Conventi ...

ePosters
Gene Expression Patterns in Donor-matched Mesenchymal Stem Cells and Osteocytes from Human Trabecular Bone
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK

The study aimed to investigate gene expression profiles of osteocytes in healthy and OA bone and to compare with donor - matched MSCs.
Pharmacological Responses in Cultured Human iPSC-Derived Cortical Neurons Using Multi-Electrode Array
(1) Department of Electronics and Intelligent Systems, Tohoku Institute of Technology, Sendai, Miyagi, Japan; (2) Japan Society for the Promotion of Science, Tokyo, Japan; (3) Axol Bioscience Ltd., Ca

The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease mechanisms and drug responses. However, the culture time required for the full functional maturation of individual neurons and networks is uncertain. We investigated the development of spontaneous electrophysiological activity and pharmacological responses for over 1 year in culture using multi-electrode arrays (MEAs).
Translational Research of oral Neural Crest-Derived Stem Cells (oNCSCs) in Regenerative Dentistry
1Stavropol State Medical University, Russian Federation, 2Praxisteam Hasslinghausen, Germany, 3Implantology Center Kassel, Germany, 4Witten/ Herdecke University, Germany, 5University of Reading, UK, 6

In this review poster, we summarize current knowledge on the oral neural crest-derived stem cell populations (oNCSCs) and discuss their potential in regenerative periodontology as a part of regenerative dentistry.
Different Pathways of Regenerative Medicine
TRM Leipzig, Universität Bielefeld

Altough regenerative medicine is rapidly developing there is neither a technical definition nor a common use in practice. The aim of this study is to draw the line at the limits of regeneration and medicine in order to figure out a proper understanding of regenerative medicine. Furthermore, the analysis reveals a prospering future. It has shown that regenerative medicine technologies are used for a variety of therapeutic applications.
Design and Validation of Bioluminescent Assays for 3D Cell Culture Models Poster
Promega Corporation

Cells cultured in 3D model systems often acquire relatively large in vivo-like structures compared to the thickness of a 2D monolayer of cells grown on standard plastic plates.
iPSC-Derived Cardiomyocytes and Luciferase Reporters: A Robust Reporting Platform for Monitoring Cardioprotection and Pathway Biology in Endogenous Human Tissue Cells
Promega Corporation

Pathophysiological conditions, medical interventions, and off-target toxicities can all result in cellular oxidative stress. In cardiac myocytes, prolonged and/or excessive oxidative stress can lead to cardiotoxicity: a primary cause of developmental delays, black-box warnings, and post-launch withdrawal of pharmaceuticals.
Whole Transcriptome RNA-SEQ with Ion Torrent Platform: FFPE, Fresh LCM and FFPE LCM Samples. Increasingly Difficult
1Pisa Science Founda:on, Pisa; Italy 2Department of Pathology, Pisa University Hospital, Pisa, Italy

We developed a high performance method to analyze the whole transcriptome of our FFPE samples, obtaining a very high number of reads (78,186,377 usable reads) perfectly comparable with samples with a large amount of RNA such as samples obtained from cells or fresh tissues.
Human iPSC-derived hepatocytes and cardiomyocytes for drug toxicity testing
ReproCELL, Inc.

Human iPS-derived hepatocytes (ReproHepato™) and cardiomyocytes (ReproCardio 2™) are useful for in vitro toxicity assays.
Development of a novel xeno-free medium for feeder-free culture of human stem cells
ReproCELL, Inc.

A new xeno-free medium (ReproXFTM) has been developed for feeder-free culture of stem cells.
Novel culture medium using a small-molecule agonist of thrombopoetin receptor
1ReproCELL, Inc. & 2Nissan Chemical Industries

ReproHSC medium for the culture of hematopoietic stem cells. facilitates the culture and expansion of CD34+/CD38- cells that retain their HSC properties
Application Notes
3D Cell Culture: mimicking real tissue
Tecan Group Ltd.

Technological advances in the last couple of years have enabled 3D scaffolds to be engineered that offer a real proxy for the in vivo environment which can be easily and routinely used in a cell culture laboratory. Alvetex Scaffold enables cells to develop natural, in vivo-like intercellular interactions, providing an ideal environment for real three-dimensional growth and nutrient exchange that is comparable to intra-capillary exchange in living tissues.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Stem cell research: Creating blood for high throughput screening
Tecan Group Ltd.

Many different research fields, including investigation of early human development processes, disease research, drug discovery and cellular therapy applications, require appropriate in vitro models which can accurately mimic in vivo processes to provide biologically relevant results. Pluripotent stem cells (PSCs) offer a powerful system for creating in vitro models to address these questions.
Analyzing Biological Samples
Tecan

This technical note describes the capability of Tecan’s Infinite® 200 PRO multimode reader to regulate the CO2 partial pressure inside its measurement chamber.
Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.
Sample Reformatting and Sample Archiving
FluidX

Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
FluidX

With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.
Isolation and Characterization of Human Bone-Marrow-Derived Mesenchymal Stem Cells
Millipore

Mesenchymal stem cells derived from bone marrow have become an attractive model cell system for the in vitro and in vivo study of disease states such as osteoporosis, obesity, and arthritis. We have isolated mesenchymal stem cells (MSCs) from the bone marrow aspirate of a single human donor. Human bone-marrow-derived MSCs express the mesenchymal stem cell markers STR0-1, CD44, and CD90, and do not express hematopoietic markers CD14 and CD19. Human bone-marrow-derived MSCs can be expanded for 18
Stem Cell-Derived Human Neurons in CNS Drug Discovery
Molecular Devices

Central nervous system (CNS) disorders affect many people worldwide. To increase the quality and number of drugs available for treatments of CNS disorders such as Alzheimer’s disease, schizophrenia and anxiety, the success rate of CNS drug discovery programs must be improved. The challenge in drug discovery is to develop more relevant assay systems to identify lead compounds for further development. Cell-based screening assays currently used for CNS drug discovery and development involve primary
Nucleofection® of mouse ES cells
Amaxa GMBH

Efficient delivery of DNA is crucial for gene targeting in embryonic stem cells and for successful generation of knock-out mice. Data presented in this technote show that Nucleofection® leads to a homogenous gene expression pattern in mouse ES cell colonies. In contrast to standard electroporation, Nucleofection® results in a 100% deletion of frt-flanked genes on both alleles. Viable and fertile mice were generated from transfected mouse ES cell clones.
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