Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

QIAGEN-sponsored Award Granted for Pioneering Work on Viral Infections and the Cell Biology of Protein Folding

Published: Friday, April 09, 2010
Last Updated: Friday, April 09, 2010
Bookmark and Share
The Finnish scientist Ari Helenius has received the Otto-Warburg-Medal of the German Society for Biochemistry and Molecular Biology.

Today the Finnish scientist Ari Helenius has received the Otto-Warburg-Medal of the German Society for Biochemistry and Molecular Biology (GBM). The medal is considered the highest German honor for biochemists and molecular biologists.

Helenius explored how viruses change the programming of their host cells to their own benefit. In doing so he also discovered basic principles of biological “quality control” for the folding and assembly of protein molecules. QIAGEN, leading provider of sample and assay technologies, exclusively sponsors the Otto-Warburg-Medal with a grant of 25 000 Euros. Helenius received the award today in Mosbach, Germany.

Viruses proliferate by entering living cells and replicating there – generally to the disadvantage of the infected cell. Professor Ari Helenius explored the molecular processes of how influenza viruses manipulate their host cells, in particular by studying the synthesis and folding of Hemagglutinin. This protein molecule is being built into the virus membrane.

Helenius discovered that the attacked cell not only produces more Hemagglutinin and transports it to the membrane surface – it also checks it with a quality control system, which is actually in place for normal host cell proteins. Only functional proteins that are folded accurately and have the right structure will be processed by this biochemical “sorting -machine”.

Special enzymes recognize misfolded proteins and then a sugar molecule is added as an attachment to them. Proteins having this marker cannot leave the endoplasmic reticulum, the location where they have been assembled. This testing of newly synthesized proteins is of vital importance: a faulty molecular quality control can be the cause for different diseases like cystic fibrosis and diabetes. The concepts developed by Ari Helenius are now textbook knowledge.

“Ari Helenius strongly influenced the cell biological research over decades and developed innovative experimental approaches,” says Prof. Nikolaus Pfanner, president of the GBM. „The far ranging concepts he developed based on these discoveries are commonly accepted today. A better understanding of viral infections and cellular quality control established by his work could disclose new therapeutic options in medicine in the near future.”

“We are excited to see the Otto-Warburg-Medal awarded to Ari Helenius, a pioneer of science whose findings have brought substantial advance in several disciplines,” says Dr. Thomas Schweins, Vice President Marketing and Strategy at QIAGEN. „As a provider of a multitude of solutions for sample preparation and analysis of DNA, RNA and proteins we are delighted that we can support Ari Helenius with this year’s award and in his future research.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

QIAGEN Partners with Exosome Diagnostics
Molecular testing of biofluids promises unprecedented access to gene mutations, gene expression signatures and expression levels without costly, invasive tissue biopsies.
Wednesday, July 24, 2013
Qiagen Subsidiary SABiosciences Expands RT2 Profiler PCR Arrays
Now more than 100 arrays for various disease areas available
Monday, July 05, 2010
Scientific News
Manufactured Stem Cells To Advance Clinical Research
Clinical-grade cell line will enable development of new therapies and accelerate early-stage clinical research.
Manufactured Stem Cells to Advance Clinical Research
Clinical-grade cell line will enable development of new therapies and accelerate early-stage clinical research.
Starving Stem Cells May Enable Scientists To Build Better Blood Vessels
Researchers from the University of Illinois at Chicago College of Medicine have uncovered how changes in metabolism of human embryonic stem cells help coax them to mature into specific cell types — and may improve their function in engineered organs or tissues.
Long-Term Culturing of Adult Stem Cells
A new procedure developed by Harvard Stem Cell Institute researchers (HSCI) at Massachusetts General Hospital (MGH) may revolutionize the culturing of adult stem cells.
Naked Mole Rat Exhibits “Extraordinary” Cancer Resistance
Scientists are getting closer to understanding the anti-cancer mechanism of the naked mole rat by making induced pluripotent stem cells.
Solutions for Biotherapeutic Characterization
Innovation to speed the routine.
Reclaiming The Immune System's Assault On Tumors
EPFL study shows a way to reclaim corrupted immune cells.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
Body’s Own Gene Editing System Generates Leukemia Stem Cells
Inhibiting the editing enzyme may provide a new therapeutic approach for blood cancers.
Cirrhosis-Causing Cells Converted to Healthy Liver Cells in Mice
New approach that repairs liver from within may be more efficient than cell transplants.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!