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Stem Cell Transplant that 'Rebuilds Brain Circuitry'

Published: Tuesday, November 29, 2011
Last Updated: Tuesday, November 29, 2011
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A brain transplant of stem cells has worked in mice in a breakthrough that signals new hope for conditions from autism to Parkinson’s disease.

Scientists put healthy stem cells from mouse embryos into the brains of adult rodents who were unable to use leptin, a hormone that tells the body to stop eating.

The transplant worked to the extent that the creatures were able to process leptin again – and duly lost weight.

The U.S. researchers said they  studied obesity only because it would be obvious whether the experiment had worked.

Their true target in treating a critical region of the brain was complex conditions such as Parkinson’s, autism, epilepsy, motor neuron disease and spinal cord injuries.

The ‘blank’ stem cells turned into four different types of neuron, or brain cell, and connected up with existing cells, the journal Science reports.

Jeffery Macklis, of Harvard University, said: ‘We have used complex circuitry as a test case for whether precisely selected and controlled neuron transplants could rewire the brain.

‘What we found is that these neurons not only turned into the right types of cells, but they sent signals to the recipient’s brain and received signals from the recipient’s brain.

‘The next step for us is to ask parallel questions of other parts of the brain and spinal cord, those involved in ALS [motor neuron disease] and with spinal cord injuries.

'Can we rebuild circuitry in the mammalian brain? I suspect that we can.’


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