Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Early Ontogenic Origin of the Hematopoietic Stem Cell Lineage

Published: Friday, March 09, 2012
Last Updated: Friday, March 09, 2012
Bookmark and Share
This study provides functional evidence that specification of the HSC lineage takes place early in ontogenesis, immediately after the start of gastrulation.

Abstract

Several lines of evidence suggest that the adult hematopoietic system has multiple developmental origins, but the ontogenic relationship between nascent hematopoietic populations under this scheme is poorly understood. In an alternative theory, the earliest definitive blood precursors arise from a single anatomical location, which constitutes the cellular source for subsequent hematopoietic populations. To deconvolute hematopoietic ontogeny, we designed an embryo-rescue system in which the key hematopoietic factor Runx1 is reactivated in Runx1-null conceptuses at specific developmental stages. Using complementary in vivo and ex vivo approaches, we provide evidence that definitive hematopoiesis and adult-type hematopoietic stem cells originate predominantly in the nascent extraembryonic mesoderm. Our data also suggest that other anatomical sites that have been proposed to be sources of the definitive hematopoietic hierarchy are unlikely to play a substantial role in de novo blood generation.

This article is published online in Proceedings of the National Academy of Sciences of the United States of America and is free to access.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Biobanking in a Constantly Developing Medical World
Biomaterial resources such as tissues, cells, blood, and serum have played a critical role in academic research.
Wednesday, November 06, 2013
International Heart Valve Bank Survey: A Review of Processing Practices and Activity Outcomes
Since the first heart valve bank (HVB) started in New Zealand in 1962, the recovery, processing, and storage techniques have been constantly evolving.
Wednesday, November 06, 2013
Developing a Semantically Rich Ontology for the Biobank-Administration Domain
Recent research has provided compelling examples of using semantic web technologies, such as ontologies, to retrieve research-relevant data from biobanks.
Tuesday, October 15, 2013
Patient Understanding and Awareness of their Roles as Research Stakeholders in a Cancer Biobank
A patient’s informed consent should imply that the patient has received complete information and fully understands its meaning.
Tuesday, September 10, 2013
Telethon Network of Genetic Biobanks: a Key Service for Diagnosis and Research on Rare Diseases
Recent advances in the technology of molecular biology and genetics have contributed to raise the awareness of the importance of coordinated biobanking activity.
Tuesday, September 10, 2013
Synthetic Surface for Expansion of Human Mesenchymal Stem Cells in Xeno-Free, Chemically Defined Culture
This study evaluates the ability of the Corning Synthemax Surface to support long-term expansion of hMSCs in serum-free, defined medium.
Friday, August 16, 2013
Cryopreservation Causes Genetic and Epigenetic Changes in Zebrafish Genital Ridges
Recent studies have pointed out that cryopreservation can cause molecular alterations in cells at different levels that may interfere with normal embryo development.
Thursday, July 18, 2013
BioBanking as the Central Tool for Translational Medicine
Global healthcare changes forms the basis for the rapid development of centralized large scale biobank facilities.
Monday, June 24, 2013
Establishing a Southern Swedish Malignant Melanoma OMICS and Biobank Clinical Capability
Current research developments and future healthcare solutions are expected to be closely linked to the utility of biobank initiatives.
Friday, March 22, 2013
Effect of Different Freezing Rates During Cryopreservation of Rat MSCs using Combinations of HES and DMSO
In this study researchers from Fraunhofer Institute for Cell Therapy and Immunology attempt an initial comparison of two independent factors: freezing rates and cryopreservation.
Thursday, November 08, 2012
Cryopreserved Reticulocytes Derived from Stem Cells can be Invaded by Cryopreserved Plasmodium vivax Isolates
The cryopreservation method described in this paper provides a continuous and substantial source of reticulocytes, possibly a first step to achieve the continuous in vitro culture of P. vivax.
Wednesday, November 07, 2012
New national Biobank of The Danish Center for Strategic Research on Type 2 Diabetes
This paper aims to describe the biobank logistics and how the biological samples are collected, handled, shipped and stored.
Friday, November 02, 2012
Human Blood RNA Stabilization in Samples Collected and Transported for a Large Biobank
The study strongly suggests that special collection tubes are necessary for RNA stabilization and they should be used for establishing new biobanks.
Friday, October 05, 2012
Biobanking for Health Research in Brazil: Present Challenges and Future Directions
This article outlines and discusses Brazil's new regulations on the use of human biological materials for research.
Monday, September 10, 2012
Evaluation of Distinct Freezing Methods and Cryoprotectants for Human Amniotic Fluid Stem Cells Cryopreservation
Researchers from the University of São Paulo Medical School have evaluated the effects of two cryopreservation methods and four distinct cryoprotectants in the AFSCs viability and main characteristics maintenance after liquid nitrogen storage.
Monday, August 06, 2012
Scientific News
Bile Acid Supports Production of Blood Stem Cells
A research group at Lund University has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.
New Biomarker to Assess Stem Cells Developed
A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.
Tricked-Out Immune Cells Could Attack Cancer
New cell-engineering technique may lead to precision immunotherapies.
Edited Stem Cells Offer Hope of Precision Therapy for Blindness
Findings raise the possibility of treating blinding eye diseases using a patient's own corrected cells as replacement tissue.
Hacking the Programs of Cancer Stem Cells
All tumor cells are the offspring of a single, aberrant cell, but they are not all alike.
Newfound Strength in Regenerative Medicine
A promising new approach uses direct mechanical stimulation to repair severely damaged skeletal muscles.
Mapping out Cell Conversion
Researchers develop algorithm that takes the field of cell reprogramming forward.
Donor's Genotype Controls the Differentiation of IPS Cells
Pluripotent stem cells derived from different cell types are equally susceptible to reprogramming, indicates a recent study by the University of Helsinki and the National Institute for Health and Welfare, Finland. However, the genotype of the donor strongly influences the differentiation of the stem cell.
Signals That Make Early Stem Cells Identified
Researchers at The Rockefeller University have identified a new mechanism by which cells are instructed during development to become stem cells
Healing Scarred Hearts
Findings suggest stem cells may one day be used to regenerate damaged tissue after heart attack.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!