Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Implanted Heart Cells Stifle Irregular Rhythms

Published: Wednesday, August 29, 2012
Last Updated: Wednesday, August 29, 2012
Bookmark and Share
Scientists explore the potential of repairing injured hearts with infusions of heart cells derived from stem cells.

Heart cells derived from human stem cells can protect injured guinea pig hearts against abnormal rhythms, a new study showed. Similar heart cell transplants might one day hold promise for treating damaged human hearts.

Heart attacks are a leading killer of men and women nationwide. Survivors have damaged heart tissue and an increased risk for life-threatening arrhythmia-an irregularity in the rate or rhythm of the heartbeat.

Earlier research led by Drs. Charles E. Murry and Michael A. Laflamme at the University of Washington showed that these cells could improve the structure and the function of damaged hearts in rats and mice.

But it was unclear if the transplanted cells could properly beat in sync with heart muscle inside the animals' bodies. Mice and rats have rapid heartbeats-about 400 to 600 beats per minute.

But in a culture dish, the fastest rhythm achieved by heart cells derived from human stem cells was 240 beats per minute.

To see if transplanted human cells could beat in rhythm with a functioning heart, the scientists turned to the guinea pig. Its heart rate is about 200 to 250 beats per minute.

The research was funded by NIH's National Heart, Lung and Blood Institute (NHLBI) and National Institute of General Medical Sciences (NIGMS), along with the Geron Corporation. Results appeared online on August 5, 2012, in Nature.

The scientists transplanted the human stem-cell-derived heart cells into more than a dozen guinea pigs with damaged hearts. The cells were delivered along with a “pro-survival cocktail,” a chemical mixture that enhances engraftment.

For comparison, some animals received the cocktail along with non-heart cells derived from human embryonic stem cells. Others received only the pro-survival cocktail.

A month later, all the animals still had evidence of heart damage. But those treated with heart cells had grown some human heart tissue within scarred regions of the animals' hearts.

The heart cell group also had fewer episodes of ventricular tachycardia, an arrhythmia marked by a too-fast heartbeat.

When later challenged with electrical stimulation to the heart, only about 7% of heart cell recipients developed arrhythmia, compared to at least 50% in the other 2 groups.

The researchers next assessed how well the transplanted cells could sync with the rhythm of the guinea pig heart. They tagged the stem-cell-derived heart cells with fluorescent molecules that flashed with each contraction.

Labeled cells transplanted to uninjured hearts became strongly coupled to the animals' heart rhythms under a variety of conditions. Transplants to injured hearts generally included both coupled and uncoupled regions.

“In our study, we discovered that the heart cell grafts do, in fact, couple to the guinea pig hearts,” Laflamme says. “We show that the transplantation of these cells also reduces the incidence of arrhythmias.”

These results are encouraging, but the researchers note that long-term studies of safety and effectiveness must be done in larger animals before this type of therapy could be considered for humans.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

NIH Funds Biobank To Support Precision Medicine Initiative Cohort Program
$142 million over five years will be awarded to the Mayo Clinic to establish the world’s largest research-cohort biobank for the PMI Cohort Program
Friday, May 27, 2016
Molecule Proves Key to Brain Repair After Stroke
Scientists found that a molecule known as growth and differentiation factor 10 (GDF10) plays a key role in repair mechanisms following stroke.
Tuesday, November 10, 2015
A Patient’s Budding Cortex — In A Dish?
Networking neurons thrive in 3-D human “organoid”
Friday, May 29, 2015
Drugs that Activate Brain Stem Cells May Reverse Multiple Sclerosis
NIH-funded study identifies over-the-counter compounds that may replace damaged cells.
Tuesday, April 21, 2015
Stem Cell Transplants May Halt Progression of Multiple Sclerosis
NIH-funded study yields encouraging early results.
Tuesday, December 30, 2014
Scientists Sniff Out Unexpected Role for Stem Cells in the Brain
NIH scientists find that restocking new cells in the brain’s center for smell maintains crucial circuitry.
Saturday, October 11, 2014
Suspect Gene Corrupts Neural Connections
“Diseases of synapses” demo’d in a dish - NIH-funded study.
Tuesday, August 19, 2014
Early Treatment Benefits Infants with Severe Combined Immunodeficiency
NIH-funded study identifies factors contributing to successful stem cell transplants.
Friday, August 01, 2014
Stem Cells Form Light-Sensitive 3-D Retinal Tissue
Researchers induced human stem cells to create a 3-D retina structure that responds to light. The finding may aid the study of eye diseases and could eventually lead to new therapies.
Tuesday, June 24, 2014
Stem Cell Therapy Rebuilds Heart Muscle in Primates
Human embryonic stem cells used to regenerate damaged primate hearts.
Tuesday, May 13, 2014
Too Much Protein May Kill Brain Cells As Parkinson’s Progresses
NIH-funded study on key Parkinson’s gene finds a possible new target for monitoring the disease.
Friday, April 11, 2014
NeuroBioBank Gives Researchers One-Stop Access to Post-Mortem Brains
The NIH is shifting from a limited funding role to coordinating a Web-based resource for sharing post-mortem brain tissue, a move which is expected to expedite research on brain disorders.
Tuesday, December 03, 2013
Gene-Silencing Study Finds New Targets for Parkinson’s Disease
NIH study sheds light on treatment of related disorders.
Monday, November 25, 2013
Epigenetic Clock Marks Age of Human Tissues and Cells
The age of many human tissues and cells is reflected in chemical changes to DNA. The finding provides insights for cancer, aging, and stem cell research.
Tuesday, November 05, 2013
NIH Scientists Pursue New Therapies to Improve Rare Disease Drug Development
Projects selected for potential to treat specific rare diseases.
Friday, September 13, 2013
Scientific News
A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
Heart Defect Prediction Technology Could Lead to Earlier, More Informed Treatment
Experimental method uses genetics-guided biomechanics, patient-specific stem cells.
Immune Cells Remember Their First Meal
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response – a discovery that may pave the way for new treatments for many human diseases.
Cancer Cells Coordinate to Form Roving Clusters
Rice University scientists identify ‘smoking gun’ in metastasis of hybrid cells.
Bio-Mimicry Method For Preparing & Labeling Stem Cells Developed
Method allows researchers to prepare mesenchymal stem cells and monitor them using MRI.
Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
New Bio-Glass Could Make it Possible to Re-Grow or Replace Cartilage
Researchers at Imperial College London have developed a material that can mimic cartilage and potentially encourage it to re-grow.
Stem Cell Advance Could Be Key Step Toward Treating Deadly Blood Diseases
UCLA scientists get closer to creating blood stem cells in the lab.
Harnessing Engineered Slippery Surfaces For Tissue Repair
A new method could facilitate the transfer of intact regenerating cell sheets from the culture dish to damaged tissues in patients.
Brazilian Zika Virus Strain Causes Birth Defects in Experimental Models
First direct experimental proof of causal effect, researchers say.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!