Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Race, Ethnicity Affect Likelihood of Finding a Suitable Unrelated Stem Cell Donor

Published: Monday, September 17, 2012
Last Updated: Monday, September 17, 2012
Bookmark and Share
Researchers at Moffitt Cancer Center describe the greater difficulty in finding matched, unrelated donors for non-Caucasian patients who are candidates for hematopoietic cell transplantation (HCT).

The study appeared in the August issue of Bone Marrow Transplantation.

The success of HCT depends on finding cell donors who are closely matched genetically; as the degree of mismatching increases, the success of unrelated donor HCT falls accordingly. A patient’s ideal donor is a genetically matched sibling.

The search for a perfectly matched donor for all groups takes time and affects the progression to transplantation. The National Marrow Donor Program estimates that the genetically matched donor rate is 90 percent for Caucasian patients, 70 percent for Hispanics and Asians, and 60 percent for those of African ancestry.

“Using unrelated adult donors to facilitate HCT has provided major opportunities for patients without a matched sibling donor. In fact, the rate of unrelated donors now exceeds the rate of related donor HCT,” said Joseph Pidala, M.D., M.S., assistant member of Moffitt’s Blood & Marrow Transplant Department and a member of the Immunology Program. “Using data available at Moffitt, we sought to describe the determinants of a successful, unrelated donor search and to explore the contribution of donor identification versus patient characteristics leading to successful transplantation outcome.”

According to Pidala, many patients can achieve prolonged, condition-free survival after unrelated donor HCT. There is, however, a need to understand “modifiable factors” that limit access to unrelated donor HCT.

The researchers concluded that the difficulties in finding well-matched donors in some minority groups were likely related to the degree of genetic heterogeneity within those groups, as well as their underrepresentation in donor pools.

They concluded that when compared to Caucasians, African-Americans, Hispanics and Native Americans have greater difficulty in finding a suitably matched unrelated donor, and less likelihood of successfully reaching HCT. Other barriers to HCT include age and disease progression.

“This research speaks to the need for reducing the time from HCT consultation to donor identification and HCT,” Pidala said. “Survival benefit for HCT is dependent upon finding a suitable donor in a timely manner and addressing modifiable barriers to reaching HCT.”

“Our data are consistent with the expectation that if suitable unrelated donors could be more expeditiously identified, patient outcomes would improve, particularly for racial and ethnic minorities and for patients with better performance status,” concluded Pidala and his colleagues. “Increased representation of ethnic minorities within unrelated donor registries will increase the likelihood of finding a suitable donor.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Novel Mechanism Controlling Lung Cancer Stem Cell Growth
Moffitt Cancer Center researchers have discovered a novel mechanism that plays an important role in the maintenance of lung cancer stem cells.
Thursday, April 09, 2015
Moffitt Cancer Center Researchers Identify Genetic Variants for Prostate Cancers
Researchers have developed a method for identifying aggressive prostate cancers that require immediate therapy.
Monday, June 24, 2013
Peripheral Blood Stem Cell Transplants from Unrelated Donors Associated with Chronic GHVD
Moffitt cancer center researcher, colleagues have conducted a two-year clinical trial.
Tuesday, October 23, 2012
Scientific News
Human Stem Cells to Rapidly Generate Bone, Heart Muscle
A new study shows that combining positive and negative signals can quickly and efficiently steer stem cells down complex developmental pathways to become specialized tissues that could be used in the clinic.
New Therapeutic Targets For Small Cell Lung Cancer Identified
Researchers at UTSW Medical Center have identified a protein termed ASCL1 that is essential to the development of small cell lung cancer.
New Mechanism of Tuberculosis Infection
Researchers have identified a new infection mechanism of tuberculosis that could lead to a new therapeutic angle.
Modelling ALS Requires ‘Aged’ Stem Cells
Research suggests engineered cells are too ‘young’ to accurately model ALS and should be 'aged' to speed progress toward finding potential treatments.
Protein Reinforces Growth of Damaged Muscles
Biologists have found a protein involved in stem cells that bolsters damaged muscle tissue growth - potential for muscle degeneration treatments.
Treating HIV with Cancer-Fighting Gene Shows Promise
A type of gene immunotherapy that has shown promising results against cancer could also be used against HIV.
'Antigen-Presenting Cell' Defends Against Cancer
Through advanced imaging, researchers have identified cells that encourages increases in immune system cancer defences.
Rapid Generation from Stem Cells
Researchers coax human stem cells to rapidly generate bone and heart muscle by directing stem cells down complex developmental pathways.
HIV Hides No Longer
Researchers are working to create proteins that clear HIV-infected cells in order to eliminate latent infection and dormancy.
R&D Agreement for Development of CtDNA Diagnostics
SeraCare and NIST partner for development of ctDNA diagnostic assay reference materials.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!