Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Unique Extracellular Matrix Combinatorial Library

Published: Wednesday, November 07, 2012
Last Updated: Tuesday, November 06, 2012
Bookmark and Share
New library provides a powerful tool for identifying the cellular adhesion profile of users cell line.

AMSBIO is a leading supplier of innovative tools for growing cells in a physiologically relevant manner.

A unique Extracellular Matrix (ECM) Mimetic Library for engineering surfaces to direct receptor binding specificity, signalling and growing cells in 3D has been launched.

Containing nearly 300 biomimetics of Fibronectin, Vitronectin, Laminin and Collagen, for coating plates or creating 3D culture scaffolds, AMSBIO's new ECM combinatorial library provides a powerful tool for identifying the cellular adhesion profile of users cell line or tumour against the widest commercially available collection of cell surface receptor binding peptide motifs.

The extracellular microenvironment, defined by biochemical and physical cues, is a deciding factor in a wide range of cellular processes not confined solely to oncology.

These include cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions.

Being able to engineer the ECM microenvironment provides clear benefits in studies of cell and tissue engineering and related applications.

Currently existing technology offers simple (and merely adequate) environments that facilitate basic cell processes such as adhesion.

The simple presentation of motifs involved in cell adhesion is not optimal for controlling more integrated processes.

Crosstalk among signalling pathways acts synergistically to enhance cellular responses such as cell adhesion and/or proliferation.

A recent study showed that a combination of extracellular matrix derived peptides presented on a surface may enhance cell adhesion strength and focal adhesion assembly.

This combinatorial presentation of ECM peptides on cell growth surfaces may also promote elevated proliferation rates of primary or stem cells.

Based upon the AMSBIO ECM combinatorial library, the ready to-use MAPTrix™ Array provides a means to regulate a variety of cell surface receptors for users cell studies.

The basic layout of the MAPTrix™ Array is comprised of avß3 and its complementary integrins such as a2ß1 (collagen), a3ß1 (laminin), a5ß1 (fibronectin), and heparin binding motif.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Novel Organoid Matrix Enables Long-Term Culture of Human Hepatocytes
Organoid growth matrix to enable long-term culture of genome-stable bipotent stem cells from adult human liver.
Saturday, January 31, 2015
Webinar Addresses 3D Cell-Based Models for Regenerative Medicine
Dr Elad Katz presents new on-demand webinar.
Friday, October 25, 2013
Scientific News
A Gene-Sequence Swap Using CRISPR to Cure Haemophilia
For the first time chromosomal defects responsible for hemophilia have been corrected in patient-specific iPSCs using CRISPR-Cas9 nucleases
Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support
A new study reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer.
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Scientists Create CRISPR/Cas9 Knock-In Mutations in Human T Cells
In a project spearheaded by investigators at UC San Francisco, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
Zebrafish Reveal Drugs that may Improve Bone Marrow Transplant
Compounds boost stem cell engraftment; could allow more matches for patients with cancer and blood diseases.
New Material Forges the Way for 'Stem Cell Factories'
Researchers have discovered the first fully synthetic substrate with potential to grow billions of stem cells. The researchcould forge the way for the creation of 'stem cell factories' - the mass production of human embryonic (pluripotent) stem cells.
Liver Regrown from Stem Cells
Scientists have repaired a damaged liver in a mouse by transplanting stem cells grown in the laboratory.
Immunotherapy Shows Promise for Myeloma
A strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
'Google Maps' for the Body
Scientists have revealed research that uses previously top-secret technology to zoom through the human body down to the level of a single cell that could be a game-changer for medicine.
Adaptimmune's Novel Cancer Therapeutics Show Positive Clinical Trial Results
The company has announced that positive data from its Phase I/II study of its affinity enhanced T-cell receptor (TCR) therapeutic targeting the NY-ESO-1 cancer antigen in patients with multiple myeloma has been published.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!