Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
Scientific Community
Become a Member | Sign in
Home>News>This Article

Stem Cells Created from Patient’s Own Blood

Published: Tuesday, December 04, 2012
Last Updated: Tuesday, December 04, 2012
Bookmark and Share
Scientists have discovered a patient-friendly and efficient way to make stem cells out of blood, increasing the hope that scientists could one day use stem cells made from patients’ own cells to treat cardiovascular disease.

The study, also funded by BHF and the Wellcome Trust, outlines a way for scientists to get the cells they need to make induced pluripotent stem (iPS) cells from a routine blood sample. Previously scientists have struggled to find an appropriate type of cell in the blood that can be turned into a stem cell, and often make iPS cells from skin or other tissues, which can require a surgical procedure, like a biopsy. The study was led by Dr Amer Rana, BHF Professor Nick Morrell and Dr Ludovic Vallier from the Wellcome Trust-MRC Cambridge Stem Cell Institute.

Dr Amer Rana and his colleagues grew patients’ blood in the lab and isolated what are known as ‘late outgrowth endothelial progenitor cells’ (L-EPCs) to turn into iPS cells. The iPS cells can then be turned into any other cell in the body, including blood vessel cells or heart cells – using different cocktails of chemicals. Scientists use these cells to study disease, and ultimately hope to grow them into tissue to repair the damage caused by heart and circulatory diseases.

Dr Amer Rana, of the University of Cambridge, said of the research:

“We are excited to have developed a practical and efficient method to create stem cells from a cell type found in blood. Tissue biopsies are undesirable – particularly for children and the elderly – whereas taking blood samples is routine for all patients.
“Researchers can freeze and store the blood cells, and then turn them into iPS cells at a later stage, rather than having to transform them as soon as they are sourced, as is the case for other cell types used previously. This will have tremendous practical value – prolonging the ‘use by’ date of patient samples.”

Shannon Amoils, Research Advisor at the BHF, said:

“iPS cells offer great potential – both for the study and potentially the future treatment of cardiovascular diseases. As iPS cells are made from the patient’s own tissue, they can be used to study diseases and hopefully one day to repair damaged tissue without being attacked by the body’s immune system.
“Being able to efficiently produce iPS cells using cells from a blood sample will make it easier for researchers to push this technology forward. But there are still many hurdles to overcome before this kind of technique could be used to treat patients.”

Dr Paul Colville-Nash, regenerative medicine Programme Manager at the MRC, added:

“iPS cell technology offers an exciting new approach to building lab-based models of disease, which can be used to understand illness and test new drugs, as well as the possibility for cell replacement therapy in the longer term. Being able to produce iPS cells from an easy to obtain source such as blood should further support the rapid progress being made in this field and enhance the application of this technology to the fight against human disease.”

Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,200+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Liver Regrown from Stem Cells
Scientists have repaired a damaged liver in a mouse by transplanting stem cells grown in the laboratory.
Wednesday, July 22, 2015
‘Mini Bile Ducts’ used to Discover New Drugs that could Prevent Liver Damage
An experimental cystic fibrosis drug has been shown to prevent the disease’s damage to the liver, thanks to a world-first where scientists grew mini bile ducts in the lab.
Tuesday, July 14, 2015
£25m to Kick-Start ‘Industrial Revolution’ in Regenerative Medicine
Applications will include Parkinson’s disease, cardiovascular disease, wound and musculoskeletal repair, eye disorders and deafness.
Wednesday, September 11, 2013
3D Tissue Grown from Stem Cells - New Model System for Brain Development
An international team of researchers has used stem cells to create a 3D structure that mimics early human brain development.
Monday, September 02, 2013
New Type of Blood Stem Cell Could Help Solve Platelet Shortage
Scientists have identified a new type of bone marrow stem cell in mice that is primed to produce large numbers of vital blood-clotting platelets.
Tuesday, August 13, 2013
£93 Million Package of Support Announced for UK’s Health Industries
Innovative business and academic projects will benefit from a new £93.2 million package of support.
Wednesday, July 31, 2013
Scientists Transplant Photoreceptors from Retina Grown ‘in a Dish’
Scientists have carried out the first successful transplant of light-sensitive photoreceptor cells taken from a synthetic retina, grown ‘in a dish’ from embryonic stem cells.
Tuesday, July 23, 2013
£20m Boost for UK Regenerative Medicine
The MRC and British Heart Foundation (BHF) announced £20m of funding to boost the development of regenerative medicine therapies.
Thursday, April 11, 2013
Human Brain Research Made Easier by Database
Researchers will be able to access samples from more than 7,000 donated human brains to help study major brain diseases, thanks to a new on-line database, launched by the MRC.
Thursday, March 21, 2013
MRC Delivering on the Life Sciences Strategy, One Year On
The Medical Research Council has made significant progress in implementing the measures outlined in last year’s Strategy for UK Life Sciences, according to a progress update published by the Government.
Tuesday, December 11, 2012
First Randomised Controlled Trial to Show Spinal Cord Regeneration in Dogs
Medical Research Council researchers have shown it is possible to restore co-ordinated limb movement in dogs with severe spinal cord injury (SCI).
Monday, November 19, 2012
International Collaboration Brings Stem Cell Clinical Trials a Step Closer
Funding for two ambitious projects aimed at bringing stem cell treatments to the point of clinical trial has been unveiled by the Medical Research Council (MRC) today.
Friday, October 30, 2009
Setting the Record Straight: Hybrid Embryo Research
The Medical Research Council (MRC) sets the record straight following concerns about the level of investment in hybrid stem cell research, raised on the front page of today’s Independent.
Tuesday, October 06, 2009
MRC welcomes new blueprint for life sciences
A new Blueprint to put innovation at the heart of healthcare delivery in the UK has been launched by Lord Drayson and Lord Darzi at Imperial College London.
Wednesday, July 15, 2009
Virus-free Pluripotency for Human Cells
Scientists have paved the way for stem cells made from skin cells to be safely transplanted into humans – by overcoming one of the main health risks associated with previous techniques.
Monday, March 02, 2009
Scientific News
Gene Editing Corrects Sickle Cell Mutation
Researchers demonstrate a potential pathway to developing gene-editing treatments for sickle cell disease.
ALS Study Reveals Role of RNA-Binding Proteins
The findings are a significant step forward in validating RNA-based therapy as a treatment for ALS.
3D-Printed Heart-On-A-Chip with Integrated Sensors
Researchers have created the first 3D-printed organ-on-a-chip with integrated sensors, paving the way for more complex, customizable devices.
Gene Therapy Going Global with Portable Device
Portable 'gene therapy in a box' could make future cancer and HIV cures affordable in developing countries.
RNA-Binding Proteins Role in ALS Revealed
Researchers describe how damage to RNA-binding protein contributes to ALS, isolating a possible therapeutic target.
Genome Engineering Paves Way For Sickle Cell Cure
Researchers from UC Berkeley have used CRISPR-Cas9 gene editing to fix the mutated gene responsible for sickle cell disease.
Preventing Alzheimer's in Mice
Researchers have prevented the Alzheimer’s development in mice by using a virus delivery system to transport a specific gene into the brain.
Link Between Heart and Blood Cells in Early Development Found
Researchers have identifed a key factor in determining the fate of early undifferentiated cells during development.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Scientists Speed Up Muscle Repair
Researchers discovered genetically modified mice were able to support far more regenerative stem cells, for muscle repair, than previously thought.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos