Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Cytheris Publication in Blood Demonstrates CYT107 Reverses Lymphopenia

Published: Tuesday, February 05, 2013
Last Updated: Monday, February 04, 2013
Bookmark and Share
Data strongly supports development of CYT107 for treatment of PML in lymphopenic patients.

Cytheris SA has announced the publication of a paper demonstrating that Cytheris' CYT107, glycosylated recombinant human interleukin-7 (glycosylated r-h-IL7) can enhance immune T cell recovery after a T cell-depleted (TCD) allogeneic hematopoietic stem cell transplantation (allo-HSCT).

The study detailed in the paper demonstrated an increase in functional T cells, including viral-specific T cells that recognize CMV, and enhanced T cell receptor diversity. Additionally, there was no significant GVHD or other serious toxicity.

The paper by Drs. Perales and van den Brink has been pre-published in the on-line version of the journal Blood (http://www.ncbi.nlm.nih.gov/pubmed/23012326).

It details the phase I study performed in 12 patients undergoing TCD allo-HSCT. The paper is titled "Recombinant Human Interleukin-7 (CYT107) Promotes T Cell Recovery Following Allogeneic Stem Cell Transplantation."

"Lymphopenia post-HSCT is a serious problem leading to mortality and morbidity, notably from potentially life-threatening infections and relapse. Several of these infections are resistant to standard treatments or have no treatment at all," said Dr Miguel Perales, MD, Director, Adult Bone Marrow Transplantation Fellowship, Memorial Sloan-Kettering Cancer Center, New York.

Dr Perales continued, "CYT107 is the first agent to demonstrate the ability to reverse post-transplant lymphopenia without increasing risks. It may offer the possibility to restore the T-cell immune system to fight these serious and often fatal infections, and improve survival."

"These data confirm the potential seen in other studies for CYT107 to treat lymphopenia and lymphopenia driven diseases. PML, Cytheris lead indication for CY107, is a rare and devastating disease with one year mortality of 40-50 per cent that is caused by reactivation of latent JC virus in lymphopenic patients," said Therese Croughs, chief medical officer at Cytheris.

Croughs continued, "We have already gathered clinical data supporting the efficacy and safety of CYT107 in PML through several compassionate use treatments. These new data in TCD allo-HSCT patients are particularly interesting in the context of PML due to the virus-specific immune responses. They also open the future possibility of use of CYT107 to treat resistant viral infections, such as CMV, in post-transplant and other lymphopenic populations."

The study was a phase I trial of r-hIL-7 (CYT107) in recipients of TCD allo-HSCTs. Twelve patients were treated with escalating doses of CYT107 administered weekly for 3 weeks. At baseline, patients were profoundly lymphopenic.

CYT107 induced a doubling in CD4+ and CD8+ T cells. The main effect of IL-7 was an expansion of effector memory T cells, the predominant subset identified in Cytheris patients. There was no significant effect on CD4+CD25+FoxP3+ T cells, NK or B cells.

Importantly, there were not only quantitative increases in T cells after a short course of IL-7, but an increase in functional T cells, including viral-specific T cells that recognize CMV. Enhanced TCR diversity was also observed after treatment.

The study drug was well tolerated with only one patient developing acute skin GVHD. The results indicate that r-hIL-7 can enhance immune recovery after a TCD allo-HSCT without causing significant GVHD or other serious toxicity.

"The results announced today strongly support the Cytheris strategy to conduct a pivotal registration study of CYT017 in PML," said Damian Marron, chief executive officer at Cytheris. "PML affects around 4,000 people in the US and EU alone. Bringing a treatment to this population would not only save and change patients' lives but would also respond to the pharmaceutical industry's desire to develop breakthrough drugs for targeted indications."

PML is a severe demyelinating disease of the central nervous system caused by the JC virus. It occurs in many conditions leading to severe lymphopenia such as HIV infection, some cancers and organ transplantation treated with immunosuppressive therapies.

PML is a very rare disease, affecting around four out of a million individuals. There is currently no marketed drug for the treatment of this devastating condition.

Cytheris has obtained scientific advice for a pivotal phase IIb study protocol with CYT107 in HIV-related PML. Cytheris reached an agreement with the EMA on the key study endpoints. Cytheris will start this phase IIb study, intended to be the pivotal registration study, in early 2013.

Additionally, The European Commission has granted an orphan designation for Cytheris' CYT017, glycosylated recombinant human interleukin-7 (glycosylated r-h-IL7), for the treatment of Progressive Multifocal Leukoencephalopathy (PML).


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Cytheris Announces Interim Results of Phase I Study of Recombinant Human Interleukin-7
CYT107 has shown to promote T-cell recovery following T-cell depleted allogeneic hematopoietic stem cell transplantation.
Wednesday, December 08, 2010
Cytheris Announces Phase I Study of Interleukin-7 as Immunotherapy in Treatment of Immunodeficient Transplant Recipients
Clinical trial is designed to investigate use of IL-7 in treatment of patients who are vulnerable to a variety of bacterial, viral, and fungal infections.
Thursday, April 24, 2008
Scientific News
Common Cell Transformed into Master Heart Cell
By genetically reprogramming the most common type of cell in mammalian connective tissue, researchers at the University of Wisconsin—Madison have generated master heart cells — primitive progenitors that form the developing heart.
Improving Regenerative Medicine
Lab-created stem cells may lack key characteristics, UCLA research finds.
Muscles on-a-Chip
This study may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Bile Acid Supports Production of Blood Stem Cells
A research group at Lund University has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.
New Biomarker to Assess Stem Cells Developed
A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.
Tricked-Out Immune Cells Could Attack Cancer
New cell-engineering technique may lead to precision immunotherapies.
Edited Stem Cells Offer Hope of Precision Therapy for Blindness
Findings raise the possibility of treating blinding eye diseases using a patient's own corrected cells as replacement tissue.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!