Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Stem Cells Entering Heart can be Tracked with Nano-‘Hitchhikers,’ Scientists Say

Published: Friday, March 22, 2013
Last Updated: Friday, March 22, 2013
Bookmark and Share
The promise of repairing damaged hearts through regenerative medicine has yet to meet with clinical success. But a highly sensitive visualization technique may help speed that promise’s realization.

The technique is described in a study published March 20 in Science Translational Medicine. Testing the new imaging method in humans is probably three to five years off.

Human and animal trials in which stem cells were injected into cardiac tissue to treat severe heart attacks or substantial heart failure have largely yielded poor results, said Sam Gambhir, PhD, MD, senior author of the study and professor and chair of radiology. “We’re arguing that the failure is at least partly due to faulty initial placement,” he said. “You can use ultrasound to visualize the needle through which you deliver stem cells to the heart. But once those cells leave the needle, you’ve lost track of them.”

As a result, key questions go unanswered: Did the cells actually get to the heart wall? If they did, did they stay there, or did they diffuse away from the heart? If they got there and remained there, for how long did they stay alive? Did they replicate and develop into heart tissue?

“All stem cell researchers want to get the cells to the target site, but up until now they’ve had to shoot blindly,” said Gambhir, who is also the Virginia and D.K. Ludwig Professor in Cancer Research and director of the Molecular Imaging Program at Stanford. “With this new technology, they wouldn’t have to. For the first time, they would be able to observe in real time exactly where the stem cells they’ve injected are going and monitor them afterward. If you inject stem cells into a person and don’t see improvement, this technique could help you figure out why and tweak your approach to make the therapy better.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,900+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Stem Cells Police Themselves to Reduce Scarring
Scientists have discovered stem cells in muscle fibers change gene expressions to respond to injury.
Tuesday, November 29, 2016
Gene Therapy for Blistering Skin Disease Shows Promise
Grafting genetically altered skin onto patients’ chronic wounds marks the first time skin-based gene therapy has been demonstrated to be safe and effective in humans.
Wednesday, November 02, 2016
Mechanisms of Parkinson’s Pathology
Defects that lead to cells’ failure to decommission faulty mitochondria cause nerve cells to die, triggering the symptoms of Parkinson’s disease.
Tuesday, September 13, 2016
Heart Muscle from Stem Cells Aid Cardiovascular Medicine
Researchers discover heart muscle cells from stem cells mirror expression patterns of key genes in donor tissue.
Friday, August 19, 2016
How Common Mutation in Asians Affects Heart Health
Researchers studied heart muscle cells derived from pluripotent stem cells to find out why a genetic mutation common in East Asians leads to an increased risk of heart disease.
Thursday, September 25, 2014
Scientists Identify Molecule that Inhibits Stem Cell Differentiation
Stanford scientists have now identified a molecule involved in keeping skin stem cells on the straight and narrow.
Friday, January 22, 2010
Stanford Researchers Unmask Proteins in Telomerase, a Substance that Enables Cancer
Researchers have identified two new proteins that make up the telomerase complex and have a lead on several more.
Tuesday, March 25, 2008
Stem Cells Helped Repair Stroke Damage in Rats, Early Stanford Study Shows
Neural cells derived from hESC helped repair stroke-related damage in the brains of rats and led to improvements in their physical abilities after a stroke.
Thursday, February 21, 2008
Stanford Researchers say new Stem Cell Method has Promise
Researchers from Wisconsin and Japan had announced that they had reprogrammed adult human cells to act like embryonic stem cells.
Friday, November 23, 2007
Stanford Experts Outline Possible Criteria for Assessing Economic Benefits of State Stem Cell Funding
Stanford researchers have published a paper using a hypothetical model of a future treatment for diabetes as a way of examining the economic benefits of funding stem cell research.
Monday, May 21, 2007
Adult Stem Cells may Have Smarts to Guard Against Cancer, Stanford Researchers Find
The findings suggest stem cells are careful when they undergo cell division so that random mutations in their chromosomes are not passed on to the next generation of stem cells.
Friday, April 20, 2007
Stanford Hires Embryonic Stem Cell Research Expert
Renee Reijo Pera, PhD is recruited as new director of human embryonic stem cell research and education for the Stanford Institute for Stem Cell Biology and Regenerative Medicine.
Tuesday, February 06, 2007
$20 Million Gift to Establish Cancer Stem Cell Research Center at Stanford
The funding will be used to launch the Ludwig Center for Cancer Stem Cell Research and Medicine.
Wednesday, November 15, 2006
Scientific News
Stem Cells in Drug Discovery
Potential Source of Unlimited Human Test Cells, but Roadblocks Remain.
Improving Drug Production with Computer Model
A model has been developed that can be used to improve and accelerate the production of biotherapeutics, cancer drugs, and vaccines.
Defining Immortality of Stem Cells
Researchers defined the mechanisms underlying increased protein quality control of pluripotent stem cells.
BioCision Forms MedCision
The new company will focus on technologies for the management and automation of vital clinical processes.
Enhancing CRISPR to Explore Further
Researchers have developed sOPTiKO, a more efficient and controllable CRISPR genome editing platform.
Regenerating Diseased Hearts
Researchers from the University of Otago have probed the potential of adult stem cell types to repair diseased hearts.
Stem Cells Police Themselves to Reduce Scarring
Scientists have discovered stem cells in muscle fibers change gene expressions to respond to injury.
Bright Red Fluorescent Protein Created
Scientists have created a bright red, fluorescent protein that could be used to track essential cellular processes.
Protein Self-Regulates Abundance
Researchers have uncovered how a protein, that plays a crucial role in embryonic stem cell renewal, is regulated.
Topical Immunotherapy Effective Against Early Skin Cancer
Combination of two commonly used drugs triggers immune response against precancerous skin lesions.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!