Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Rigid Growth Matrix: A Key to Success of Cardiac Tissue Engineering

Published: Monday, April 15, 2013
Last Updated: Monday, April 15, 2013
Bookmark and Share
UCLA team found that rigid matrices promotes the generation of more cardiomyocytes cells from ES cells.

Adult heart muscle is the least regenerative of human tissues. But embryonic cardiomyocytes (cardiac muscle cells) can multiply, with embryonic stem cells providing an endless reservoir for new cardiac tissue.

A new study by Nakano, Gimzewski and their co-workers at the University of California, Los Angeles (UCLA) suggests that the elasticity of the physical matrix used for growing cardiomyocytes outside of the body may be critical to the success of cardiac tissue engineering efforts.

Published in the journal Science and Technology of Advanced Materials Vol. 14, p. 025003 (http://iopscience.iop.org/1468-6996/14/2/025003), the study found that a stiff or rigid environment not only enhances the function of existing cardiomyocytes (as has previously been shown), but also promotes the generation of cardiomyocytes from embryonic stem (ES) cells.

It may therefore be possible to grow new heart muscle tissue from stem cells by manipulating the stiffness of the medium they're grown in.

In living organisms, a type of adult stem cells called mesenchymal stem cells (MSCs) are extremely sensitive to the elasticity of different materials, when cultured outside the body.

For example, soft growing matrices that mimic brain tissue promote the differentiation of MSCs into neurons, while rigid matrices that resemble bone tissue promote the differentiation of MSCs into bone cells.

In this study, the UCLA team examined the role of matrix elasticity on cardiac muscle development using mouse and human embryonic stem cells, which were grown on different substrates of a silicon-based organic polymer that varied in stiffness.

In addition, ES-derived cardiomyocytes displayed functional maturity and synchronization of beating when cultured with cardiomyocytes harvested from a developing embryo.

The team recommends further research on how biophysical cues determine the fate of embryonic stem cells in order to improve cardiac tissue culture methods for regenerative medicine purposes.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Study Finds Link Between Neural Stem Cell Overgrowth and Autism-like Behavior in Mice
UCLA researchers demonstrates how, in pregnant mice, inflammation can trigger an excessive division of neural stem cells.
Tuesday, October 14, 2014
Scientists Identify Link Between Stem Cell Regulation and the Development of Lung Cancer
Study explains how factors that regulate the growth of adult stem cells lead to the formation of precancerous lesions.
Tuesday, June 24, 2014
Stem Cell Gene Therapy for Sickle Cell Disease Advances Toward Clinical Trials
Gene therapy technique is scheduled to begin clinical trials by early 2014.
Tuesday, July 02, 2013
Cells Derived from Pluripotent Stem Cells may Pose Challenges for Clinical Use
UCLA researchers have found that three types of cells derived from hES cells and from iPS cells are similar to each other.
Tuesday, August 23, 2011
Scientists Reprogram Induced Pluripotent Cells into Precursors of Eggs, Sperm
The findings from UCLA researchers can possibly open the door for new treatments for infertility using patient-specific cells.
Wednesday, February 04, 2009
Scientists at UCLA Reprogram Human Skin Cells into Embryonic Stem Cells
UCLA stem cell scientists have reprogrammed human skin cells into cells with the same unlimited properties as embryonic stem cells, without using embryos or eggs.
Tuesday, February 12, 2008
Scientific News
Muscles on-a-Chip
This study may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Bile Acid Supports Production of Blood Stem Cells
A research group at Lund University has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.
New Biomarker to Assess Stem Cells Developed
A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.
Tricked-Out Immune Cells Could Attack Cancer
New cell-engineering technique may lead to precision immunotherapies.
Edited Stem Cells Offer Hope of Precision Therapy for Blindness
Findings raise the possibility of treating blinding eye diseases using a patient's own corrected cells as replacement tissue.
Hacking the Programs of Cancer Stem Cells
All tumor cells are the offspring of a single, aberrant cell, but they are not all alike.
Newfound Strength in Regenerative Medicine
A promising new approach uses direct mechanical stimulation to repair severely damaged skeletal muscles.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!