Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Discarded Immune Cells Induce the Relocation of Stem Cells

Published: Tuesday, May 28, 2013
Last Updated: Tuesday, May 28, 2013
Bookmark and Share
Scientists investigate the evolution and elimination of neutrophils.

Neutrophils are leukocytes (white blood cells) that defend the body against attack from bacteria and other disease organisms. To perform their function, these cells release toxic substances when they come into contact with microorganisms. However, release of these substances in the wrong place by damaged neutrophils can result in severe injury to blood vessels and tissues.

Evolution appears to have resolved this conflict by ensuring that neutrophils are renewed much more rapidly than most other cells in the body: approximately 1011 neutrophils are eliminated every day and an equivalent number of stem cells are released into the bloodstream. This in turn generates a second problem: what to do with all these cells that have to be eliminated.

Dr. Andrés Hidalgo and his team in the Department of Epidemiology, Atherosclerosis and Cardiovascular Imaging, led by Dr. Valentín Fuster, have discovered the function of these neutrophils expelled every day by the body.

Graduate student María Casanova Acebes (Universidad Autónoma de Madrid), found that when additional apoptotic neutrophils were injected into mice, there was an increase in the number of circulating hematopoietic stem cells, the cells that generate all blood cells.

Using a wide variety of experimental approaches, including imaging assays, pharmacological treatments and genetic analysis, the team showed that when neutrophils in the blood get old, they migrate to the bone marrow to be eliminated by specialized phagocytotic cells called macrophages. The act of phagocytosing the neutrophils alters these macrophages’ genetic properties and functions, and these changes in turn alter the function of specialized cells whose job it is to retain hematopoietic stem cells in the bone marrow. “As a consequence, the stem cells are released into the blood”, explains María Casanova, first author of the study.

According to Dr. Hidalgo, “Key questions that arise from our study relate to the role of the hematopoietic stems cells expelled from the bone marrow, and how the elimination of neutrophils might affect other important stem cell populations, for example those that produce tumors”.

The research also reveals that the aging of neutrophils follows a day/night, or circadian, cycle, suggesting possible implications for disease processes—for instance heart attack—that occur more frequently at certain times of day.

“Our study shows that stem cells are affected by day/night cycles thanks to this cell recycling. It is possible that the malign stem cells that cause cancer use this mechanism to relocate, for example during metastasis”, Hidalgo emphasizes.

But this finding could have more direct implications for cardiovascular health. According to the authors, the daily changes in the function of neutrophils could be responsible for the tendency of acute cardiovascular and inflammatory events, such as heart attack, sepsis or stroke, to occur at certain times of day.

Dr. Hidalgo concludes, “Given that this new discovery describes fundamental processes in the body that were unknown before, it will now be possible to interpret the alterations to certain physiological patterns that occur in many diseases.”


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
The Mending Tissue - Cellular Instructions for Tissue Repair
NUS-led collaborative study identifies universal mechanism that explains how tissue shape regulates physiological processes such as wound healing and embryo development.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
iPS Cells Discover Drug Target for Muscle Disease
Researchers have designed a model that reprograms fibroblasts to the early stages of their differentiation into intact muscle cells in a step towards a therapeutic for Duchenne muscular dystrophy.
Engineered Hot Fat Implants Reduce Weight Gain
Scientists at UC Berkeley have developed a novel way to engineer the growth and expansion of energy-burning “good” fat, and then found that this fat helped reduce weight gain and lower blood glucose levels in mice.
Transplanted Stem Cells Can Benefit Retinal Disease Sufferers
Tests on animal models show that MSCs secrete growth factors that suppress causes of diabetic retinopathy and macular degeneration.
MRI Scanners Can Steer Therapeutics to Specific Target Sites
Scientists from the University of Sheffield have discovered MRI scanners, normally used to produce images, can steer cell-based, tumour busting therapies to specific target sites in the body.
Team Finds Early Inflammatory Response Paralyzes T Cells
Findings could have enormous implications for immunotherapy, autoimmune disorders, transplants and other aspects of immunity.
Early Detection of Lung Cancer
The University of Manchester has signed a collaboration agreement with Abcodia to perform proteomics studies on a cohort of non-small cell lung cancer cases from the UKCTOCS biobank, with the aim of discovering new blood-based biomarkers for earlier detection of the disease.
Researchers Identify Drug Candidate for Skin, Hair Regeneration
Formerly undiscovered role of protein may lead to the development of new medications that stimulate hair and skin regeneration in trauma or burn victims.
Basis for New Treatment Options for a Fatal Leukemia in Children Revealed
Detailed molecular analyses allow new insights into the function of tumour cells and options for new treatments.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!