Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Genetically Modified Stem Cells are Effective Against Acute Respiratory Diseases

Published: Tuesday, June 18, 2013
Last Updated: Tuesday, June 18, 2013
Bookmark and Share
Administration of genetically modified mesenchymal stem cells regenerates lung tissue and stops the inflammatory process in mice with acute lung injury.

Study results were published in the American Journal of Respiratory Cell and Molecular Biology.

Acute lung injury

Acute lung injury and its more severe manifestation, the acute respiratory distress syndrome, are characterized by very severe inflammatory processes that damage the lungs with a mortality of between 40% and 50%. Currently there is no effective treatment beyond palliative care and mechanical assistance to breath.

"In the last years we have been working in the administration of human mesenchymal stem cells from adipose tissue obtained from liposuction in different pathologies," said the researcher of Human Molecular Genetics reserach group at IDIBELL Josep Maria Aran. "We have found that these stem cells are able to easily reach the lungs and there, secrete anti-inflammatory substances and growth factors."

Alarm signal

The studies conducted so far with these cells have shown a positive effect. IDIBELL and VHIR researchers have introduced a genetic modification in these cells that improves treatment.

The cytokine IL33 is a protein that acts as an alarm signal in these patients. When the damage into the lungs begins, the cells secrete this highly proinflammatory substance and elicit a very strong immune system answer.

"We believed," says Aran, "that if we modified genetically mesenchymal stem cells to secrete a molecule antagonist of IL-33, we could stop the inflammatory process and we found that, in mice, the effect was more positive than unmodified cells: regeneration of lung tissue and practically nullifies the inflammatory process in the lungs. "

IDIBELL has signed a licensing agreement with the Basque company Histocell for this genetic modification and currently they are working to make this "smart drug" may reach the clinical stage and try to patients.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

IDIBELL and VHIR licenses Histocell a Patent for Acute Respiratory Diseases with Stem Cells
It is a "smart drug" that can reduce inflammation and regenerate damaged tissue.
Tuesday, April 09, 2013
IDIBELL Licenses Histocell a Patent for Acute Respiratory Diseases with Stem Cells
It is a "smart drug" that can reduce inflammation and regenerate damaged tissue.
Wednesday, April 03, 2013
IDIBELL licenses Histocell a Patent for Acute Respiratory Diseases with Stem Cells
It is a "smart drug" that can reduce inflammation and regenerate damaged tissue.
Wednesday, March 27, 2013
Scientific News
The Mending Tissue - Cellular Instructions for Tissue Repair
NUS-led collaborative study identifies universal mechanism that explains how tissue shape regulates physiological processes such as wound healing and embryo development.
Tissue Bank Pays Dividends for Brain Cancer Research
Checking what’s in the bank – the Brisbane Breast Bank, that is – has paid dividends for UQ cancer researchers.
iPS Cells Discover Drug Target for Muscle Disease
Researchers have designed a model that reprograms fibroblasts to the early stages of their differentiation into intact muscle cells in a step towards a therapeutic for Duchenne muscular dystrophy.
Engineered Hot Fat Implants Reduce Weight Gain
Scientists at UC Berkeley have developed a novel way to engineer the growth and expansion of energy-burning “good” fat, and then found that this fat helped reduce weight gain and lower blood glucose levels in mice.
Transplanted Stem Cells Can Benefit Retinal Disease Sufferers
Tests on animal models show that MSCs secrete growth factors that suppress causes of diabetic retinopathy and macular degeneration.
MRI Scanners Can Steer Therapeutics to Specific Target Sites
Scientists from the University of Sheffield have discovered MRI scanners, normally used to produce images, can steer cell-based, tumour busting therapies to specific target sites in the body.
Team Finds Early Inflammatory Response Paralyzes T Cells
Findings could have enormous implications for immunotherapy, autoimmune disorders, transplants and other aspects of immunity.
Early Detection of Lung Cancer
The University of Manchester has signed a collaboration agreement with Abcodia to perform proteomics studies on a cohort of non-small cell lung cancer cases from the UKCTOCS biobank, with the aim of discovering new blood-based biomarkers for earlier detection of the disease.
Researchers Identify Drug Candidate for Skin, Hair Regeneration
Formerly undiscovered role of protein may lead to the development of new medications that stimulate hair and skin regeneration in trauma or burn victims.
Basis for New Treatment Options for a Fatal Leukemia in Children Revealed
Detailed molecular analyses allow new insights into the function of tumour cells and options for new treatments.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!