Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Cell Fate Secrets Revealed

Published: Tuesday, July 30, 2013
Last Updated: Tuesday, July 30, 2013
Bookmark and Share
Scientists have shed light on a critical stage of cell fate differentiation, a discovery which will influence fundamental cell biology and potentially aid our understanding of stem cell biology.

A BBSRC-funded mathematical modelling team at the University of Edinburgh together with an experimental team at the University of Pennsylvania demonstrated that a structure called a septin ring was crucial in the process of cell division and differentiation in budding yeast.

When budding yeast cells divide in a process called asymmetric cell division the original 'mother' cell and the newly formed 'daughter' cell are non-identical, follow distinct developmental programmes and even age differently.

The single-cell budding yeast is therefore an excellent model organism to study asymmetric cell division and cell fate differentiation since during each cell division a daughter cell is born with a replicative age reset to zero, like a typical stem cell, while the mother cell continues to age.

The teams discovered that the formation of the septin ring at what will become a membrane boundary between mother and daughter cells differentiates them from each other long before cell division is complete.

This process is heavily dependent on a molecule called Cdc42, which promotes the formation of the septin ring, and then concentrates in the daughter cell, causing its differentiation from the mother cell.

The team demonstrated for the first time that the hollowing of septins recruited by Cdc42 into the shape of a ring is caused by a highly localised insertion of new membrane vesicles, the process known as polarized 'exocytosis'.

Dr Andrew Goryachev, Reader in Computational Cell Biology at the University of Edinburgh, said: "This project shows how a close collaboration between theory and experiment can result in a breakthrough study that not only presents new and unexpected experimental findings, but with the heavy use of cutting-edge mathematical modelling answers a number of long-standing questions that have sparked much controversy and discussion in the international scientific literature."

Septins are already known to play important roles in diverse cellular functions and human diseases, including cell growth, division, cell migration, bacterial infection, cancer, and neurodegenerative diseases and this study pushes forward our understanding of the mechanisms of septin ring biogenesis.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Lab Grown Cells Offer Hope for New Liver Disease Treatments
Human liver cells produced from stem cells meet the current 'gold standard' for assessing drug toxicity, raising the possibility they could be used to develop new therapies for liver disease.
Monday, January 06, 2014
Stem Cell Renewal Process Discovery
Scientists have made a fundamental discovery about how the properties of embryonic stem cells are controlled.
Friday, May 03, 2013
Scientific News
New Weapon in the Fight Against Blood Cancer
This strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Zebrafish Reveal Drugs that may Improve Bone Marrow Transplant
Compounds boost stem cell engraftment; could allow more matches for patients with cancer and blood diseases.
New Material Forges the Way for 'Stem Cell Factories'
Researchers have discovered the first fully synthetic substrate with potential to grow billions of stem cells. The researchcould forge the way for the creation of 'stem cell factories' - the mass production of human embryonic (pluripotent) stem cells.
Liver Regrown from Stem Cells
Scientists have repaired a damaged liver in a mouse by transplanting stem cells grown in the laboratory.
Immunotherapy Shows Promise for Myeloma
A strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
'Google Maps' for the Body
Scientists have revealed research that uses previously top-secret technology to zoom through the human body down to the level of a single cell that could be a game-changer for medicine.
Adaptimmune's Novel Cancer Therapeutics Show Positive Clinical Trial Results
The company has announced that positive data from its Phase I/II study of its affinity enhanced T-cell receptor (TCR) therapeutic targeting the NY-ESO-1 cancer antigen in patients with multiple myeloma has been published.
Stem Cells Rescue Patients from Mitochondrial Disease
A study led by OHSU researchers has revealed a critical first step in developing a new gene and stem cell regenerative technique for treating patients with mitochondrial disease.
Eco-Friendly Nanobullet to Battle Bacteria
Researchers have developed a method to combat bacteria by engineering nanoscale particles that add the antimicrobial potency of silver to a core of lignin, a ubiquitous substance found in all plant cells.
Blood Stem Cells in a Rush -- Velocity Determines Quality
Acceleration of the G1 phase transit during cell division makes human blood stem cells more powerful.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!