Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

CeMM and Haplogen Make Available the World’s Largest Collection of Human Cell Lines

Published: Monday, September 02, 2013
Last Updated: Monday, September 02, 2013
Bookmark and Share
Haplogen and CeMM partnership will distribute requested cell lines to the research community.

Haplogen and CeMM have announced that they are making available their large collection of human cell lines that are deficient for single genes, which they have been building over the past three years as part of a public-private partnership.

The partnership, through Haplogen, will distribute requested cell lines to the research community. The collection and the technological advances that enabled its development were published in Nature Methods on August 25.

It currently includes cell line clones covering 3,000 different human genes, which represents about one third of all the genes that are active in these cells. The collection will continue to expand until all the genes have been targeted.

Although cell lines of human origin have been around for many years, they are all vastly different from each other, making them very difficult to control when performing genetic experiments, thereby limiting their use particularly for drug discovery efforts and discovering the function of genes.

This new collection circumvents this problem by providing individual gene mutations in an otherwise identical genetic background.

Prof. Giulio Superti-Furga, Director of the CeMM who initiated this project commented: “This collection will fuel research in molecular medicine where the vast majority of human genes remain poorly understood and await functional characterization. Obtaining human cells where an individual gene is inactivated has so far been difficult and very tedious. With this largest human cell line collection available to date we expect to drive countless scientific discoveries in the research community.”

“The creation of those precise mutants has become possible by the use of a haploid cell line. Destroying a single gene in haploid cells will immediately cause a detectable change - in contrast to our natural cells that always bear two copies of each gene” explains Thijn Brummelkamp, the inventor of the haploid genetics technology in human cells that was used to create this collection, and founder of Haplogen.

Georg Casari, CEO of Haplogen: “In this publication we show that these cell lines really behave as if only the gene of choice is no longer present. We have taken great care to document that the gene products are gone and that those clones have new properties as compared to the parental, unmodified cell line. We are excited to provide and distribute this resource to researchers world-wide and contribute to the advancement of medical research. Our goal is to eventually obtain mutant cell lines for every human gene.”

He continued: "At Haplogen we use this collection as an indispensable component in our research and development of antiviral medications for treating a wide range of harmful infectious diseases. This partnership of academic research at CeMM and private investment by the company has made it possible to finance this collection and build a resource to the benefit beyond the two institutions for scientists all over the world.”

The cell line collection has received financial support also from ZIT (Technology agency of the City of Vienna) and can be explored at http://clones.haplogen.org.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Improving Regenerative Medicine
Lab-created stem cells may lack key characteristics, UCLA research finds.
Muscles on-a-Chip
This study may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Therapeutic Approach Gives Hope for Multiple Myeloma
A new therapeutic approach tested by a team from Maisonneuve-Rosemont Hospital (CIUSSS-EST, Montreal) and the University of Montreal gives promising results for the treatment of multiple myeloma, a cancer of the bone marrow currently considered incurable with conventional chemotherapy and for which the average life expectancy is about 6 or 7 years.
Cat Stem Cell Therapy Gives Humans Hope
By the time Bob the cat came to the UC Davis veterinary hospital, he had used up most of his nine lives.
Bile Acid Supports Production of Blood Stem Cells
A research group at Lund University has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.
New Biomarker to Assess Stem Cells Developed
A research team led by scientists from UCL have found a way to assess the viability of 'manufactured' stem cells known as induced pluripotent stem cells (iPSCs). The team's discovery offers a new way to fast-track screening methods used in stem cell research.
Tricked-Out Immune Cells Could Attack Cancer
New cell-engineering technique may lead to precision immunotherapies.
Edited Stem Cells Offer Hope of Precision Therapy for Blindness
Findings raise the possibility of treating blinding eye diseases using a patient's own corrected cells as replacement tissue.
Hacking the Programs of Cancer Stem Cells
All tumor cells are the offspring of a single, aberrant cell, but they are not all alike.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!