Corporate Banner
Satellite Banner
Stem Cells, Cellular Therapy & Biobanking
>
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Findings Indicate How Gene Transcription is Controlled in Embryonic Stem Cells

Published: Monday, May 05, 2008
Last Updated: Monday, May 05, 2008
Bookmark and Share
In a report that appears in the journal Nature Cell Biology, BCM researchers explain that association determines fate in embryonic stem cells.

Association determines fate in embryonic stem cells, said Baylor College of Medicine researchers in a report that appears in the current issue of the journal Nature Cell Biology.

"These findings provide models of how the embryonic stem cell is maintained in its flexible state," said Dr. Zhou Songyang, professor of biochemistry and molecular biology at BCM and senior author of the report. "It provides another hint as to how gene transcription is controlled in embryonic stem cells."

One aim of embryonic stem cell research is to understand how the cells determine whether they will keep dividing and maintain a pool of embryonic cells, or start the process of cellular differentiation that results in different cell types.

Songyang and his colleagues found that two critical embryonic cell proteins – Nanog and Oct4 – associate with specific components that are parts of transcription repression complexes. These complexes affect the way that genes are expressed and carry out their tasks in the cell.

A special complex called NODE (Nanog and Oct4-associated Deacetylase) contains a critical component called Mta1 along with histone deacetylases. NODE associates with Nanog and Oct4 to control the fate of embryonic stem cells, said Songyang.

Histones are critical parts of genomic DNA structures or chromatins, acting as "spools" around which the genetic material winds in the nucleus. The DNA wraps more tightly when deacetylase removes the acetyl tails from the histones. The tight wrapping makes it hard for genes to be transcribed into the message that allows them to carry out their roles in the cell.

"Think of it as the parts of a car," said Songyang.

"If you think of Nanog as the engine that drives it, you realize that the car still needs accessories like wheels, the tailpipe, etc. We are interested in the big machinery of which proteins (like Nanog) are the drivers. We want to understand the enzymatic activities of the complexes. Then we need to identify the individual parts and ask the big question: 'How do different parts work together and why do you need special parts?'”

"We noticed that there are many histone deacetylases," he said. "Nanog uses these proteins to control gene expression and maybe also the chromatin state. When there is deacetylation, the gene is in a passive state."

"The embryonic stem cell is always at the stage of deciding whether to divide (and make more embryonic stem cells) or to differentiate," Songyang said. "All the extrinsic and intrinsic signals make the life of the embryonic stem cell transient. In other words, it has to be ready to go down either road."

"It becomes an interesting question," said Songyang. "Such a demanding state of readiness may mean that the embryonic stem cell requires a different complex at the chromatin than the somatic (or differentiated cell)."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Role of Cancer Stem Cells in Chemo-Resistance
'Wound response' of cancer stem cells may explain chemo-resistance in bladder cancer.
Friday, December 05, 2014
Experimental Drug Targets Chemo-Resistant Breast Cancer Stem Cells
The cells that remain after treatment that could potentially refuel tumor growth, researchers say.
Monday, December 14, 2009
Ronin Provides Alternate Pathway to Pristine Embryonic Stem Cells
The protein Ronin maintains embryonic stem cells in their undifferentiated state and plays roles in genesis of embryos and their development, researchers say.
Friday, June 27, 2008
Nature Mixes, Matches Genes to Keep Nerve Cells Straight
BCM researchers report that nature has to mix and match thousands of genes to generate the myriad types of neurons needed to assemble the brain and nervous system.
Thursday, June 12, 2008
Notch Controls Bone Formation and Strength
Notch, a protein that governs cell differentiation process in embryos, plays a critical role in bone formation and strength later in life.
Monday, February 25, 2008
Scientific News
Insight into Eye Diseases
Scientists recreate zebrafish cell regeneration from retinal stem cells in mice.
1960s Antibiotics Show Promise for TB Therapy
Research suggests antibiotics introduced in 1963 to treat bacterial infections show promise for tuberculosis therapy.
Analysing 10,000 Cells Simultaneously
New techniquethat traps 10,000 cells on a single chip has potential for cancer screening for individuals.
Studies Explore the Science of Cardiovascular Diseases
Two studies highlight how basic science research insights are key to future treatment breakthroughs.
Stem Cell ‘Heart Patch’ Almost Perfected
Scientists aiming to perfect and test 3D "heart patches" in animal model, last hurdle before human patients.
Using Stem Cells to Grow a 3D Lung-in-a-Dish
Researchers have created 3D lung-like tissue from lung-derived stem cells. The tissue can be used to study lung diseases.
MRI Guidance Aids Stem Cell Delivery
Scientists have delivered stem cells to the brain with unprecedented precision, infusing the cells under real-time MRI guidance.
Mechanisms of Parkinson’s Pathology
Defects that lead to cells’ failure to decommission faulty mitochondria cause nerve cells to die, triggering the symptoms of Parkinson’s disease.
Stem Cell Transplant Without Radiation or Chemotherapy
Researchers have successfully performed stem cell transplants without using radiation or chemotherapy.
Advanced Lymphoma in Remission After T-Cell Therapy
63% of trial participants who recieved two-drug combination chemo plus intermediate dose of engineered T cells went into complete remission.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!