|Design and Validation of Bioluminescent Assays for 3D Cell Culture Models Poster|
Terry L. Riss, Michael P. Valley, Chad A. Zimprich, Andrew L. Niles, Kevin R. Kupcho and Dan F. Lazar
Cells cultured in 3D model systems often acquire relatively large in vivo-like structures compared to the thickness of a 2D monolayer of cells grown on standard plastic plates.
|iPSC-Derived Cardiomyocytes and Luciferase Reporters: A Robust Reporting Platform for Monitoring Cardioprotection and Pathway Biology in Endogenous Human Tissue Cells|
Fiene, S., Thompson, A., Niles, A., Robers, M., Anson, B.
Pathophysiological conditions, medical interventions, and off-target toxicities can all result in cellular oxidative stress. In cardiac myocytes, prolonged and/or excessive oxidative stress can lead to cardiotoxicity: a primary cause of developmental delays, black-box warnings, and post-launch withdrawal of pharmaceuticals.
|Whole Transcriptome RNA-SEQ with Ion Torrent Platform: FFPE, Fresh LCM and FFPE LCM Samples. Increasingly Difficult|
Sara Franceschi1, Paolo Are*ni1, Marco La Ferla1, Generoso Bevilacqua1,2, Chiara Maria Mazzan*1 , Francesca Lessi1
We developed a high performance method to analyze the whole transcriptome of our FFPE samples, obtaining a very high number of reads (78,186,377 usable reads) perfectly comparable with samples with a large amount of RNA such as samples obtained from cells or fresh tissues.
|Human iPSC-derived hepatocytes and cardiomyocytes for drug toxicity testing|
AnnandRR; Vardaro R; Hamilton B; Akakira R; Tamura K; Yoshida S; Lin YC; Toyoda D; Kogami H; Okuda Y; Watanabe T; Inamura M
Human iPS-derived hepatocytes (ReproHepato™) and cardiomyocytes (ReproCardio 2™) are useful for in vitro toxicity assays.
|Development of a novel xeno-free medium for feeder-free culture of human stem cells|
Annand R; Okuda Y; Inamura M
A new xeno-free medium (ReproXFTM) has been developed for feeder-free culture of stem cells.
|Novel culture medium using a small-molecule agonist of thrombopoetin receptor|
Hondo M1; Nishino T2; Inamura M1
ReproHSC medium for the culture of hematopoietic stem cells. facilitates the culture and expansion of CD34+/CD38- cells that retain their HSC properties
|Human iPSC-derived hepatocytes ReproHepateTM for CYP assay and drug toxicity testing |
Annand R; Akahira R; Tamura K; Inamura M
We developed iPSC-derived hepatocytes and used them for CYP induction and cytotoxicity assays.
|Alzheimer's disease model cells derived from human iPS cells|
Honda M; Kitogo T; Kogami H; Inamura M
Alzheimer's disease model neurons were created from iPS cells to enable functional, cell-based assays for AD.
|Continuous Collection of Stem Cells from a Human Placenta Perfusion Co-Culture|
John J.S. Cadwell & James C. Hardy
The potential for human placenta-derived cells to produce stem cells in a hollow fiber bioreactor co-culture system was investigated.
|Targeting Cancer Stem Cell-Related miRNAs for Prostate Cancer Therapy|
ANSHIKA NIKITA SINGH, MEGHNA BARUAH, NEETI SHARMA
The poster focuses on the pivotal function of miRNAs in tumorigenesis by regulation of self renewal and apoptosis via cancer stem cell signalling pathways with special focus on their regulation of Epithelial to Mesenchymal transition in metastatic prostate cancer.
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