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Thursday, September 18, 2014
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Mechanisms of beneficial effects of human placenta MSC transplantation in rats with experimental ischemic stroke
Yarygin K.N., Kholodenko I.V., Konieva A.A., Burunova V.V., Tairova R.T., Gubsky L.V., Cheglakov I.B., PirogovYu.A., Yarygin V.N., Skvortsova V.I.

Human MSC transplantation significantly reduced the volume of experimental ischemic lesion in rat model. It also greatly stimulated stem and progenitor cell proliferation in the subventricular region and hippocampus and cell migration from these areas towards the ischemia site. Beneficial effects of MSC in rats with brain ischemia are likely to be associated with enhancement of host neural stem and progenitor cell proliferation and migration towards the affected area.

Superporous SIKVAV-modified PHEMA scaffold promotes stem cell adhesion
V.Vanecek, S.Kubinova, D.Horak, V.Proks, E.Sykova

Poly(2-hydroxyethyl methacrylate) (PHEMA) is successfully used as a scaffold material for tissue engineering; however, it lacks functional groups that support cell adhesion. The laminin-derived peptide sequence SIKVAV is known to mimic the function of laminin, which is one of the biologically active proteins of the extracellular matrix. In this report, the adhesion of mesenchymal stem cells (MSC) to SIKVAV-modified PHEMA was investigated.

The effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling
M. Kapcalova, M. Babic, P. Jendelova, V. Herynek, K. Likavcanova, D. Horak, M. Hajek, E. Sykova

Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor
Patricia Ap. Santiago; Claudio A Suazo; Roberto C Giordano.

In biochemical processes involving cultivation of animal cells, the supply of oxygen in culture medium is an extremely important parameter in the project of bioreactors and its operation. In this work, the global volumetric transfer coefficient of oxygen (KLa) is evaluated in a Taylor vortex flow bioreactor (TVFB) and a correlation of mass transfer, of this equipment, is proposed.

Reliable and Predictive In Vitro Assays for Myelotoxicity and Cardiotoxicity of Kinase Inhibitors
Clarke E (1), Schwengberg S (2), Kettenhofen R (2), Dos Santos G (1), Bohlen H (2)

Kinase inhibitors (KIs) represent a new class of rationally designed drugs. The success of Imatinib has prompted the development of other KIs for the treatment of various cancers and inflammation. Although more successful than conventional therapies, myelotoxicity and cardiotoxicity are often major side effects of KIs. In order to predict if newly developed molecules demonstrated significant myelotoxicity or cardiotoxicity, we assessed a number of TKIs using in vitro models.

Intra-operative Bone Marrow Processing for Bone Regeneration
E. Nedelcu MD, A. Jamali MD, L. Hill RN, J. Nolta PhD, D. Vierria RN, M. Hoze RN, D. Taylor MD PhD, C. Gresens MD, D. Dwyre MD

Concentrated stem cell products obtained from autologous bone marrow aspirate were previously shown to regenerate avascular necrosis of the bone and non-union fractures. The aspirate processing was performed using apheresis technology, however, a detailed protocol has not been published yet. The aim of our study was to develop a clinical protocol using the CobeSpectra apheresis device to process the bone marrow aspirate.

The Expression and Activity of MMPs during Zebrafish (Danio rerio) Development
N.D. Harris, D.H. Li, J.Y. Keow, C. Po, A. Hong, K. Herrmann, B.D. Crawford

Recent advances have made the zebrafish an attractive system for studying MMP activity. However, there are few commercially available antibodies against MMPs that are suitable for studies using zebrafish. The objectives of the study presented in the poster were to develop effective immunological reagents for the study of MMPs in zebrafish and to test commercially available narrow-spectrum fluorogenic MMPs substrates in in vivo zymography.

Genetic profile of human embryonic stem cells (hESC) grown under different O2 concentrations
Sonia Prado, David Montaner, Dario Melguizo,Rubén Moreno, Joaquín Dopazo and Miodrag Stojkovic.

The development of mammalian embryos during the early stages takes place in a hypoxic environment. After 11 weeks of pregnancy the mother’s blood begins to flow freely in the placental space increasing the partial pressure of oxygen [1-3]. Therefore, we hypothesized that in vitro growth of hESC in normoxic conditions (21% O2) may change the profile and differentiation potential of hESC.

Induced Pluripotency with Endogenous and Inducible Genes

The recent discovery that two partly overlapping sets of four genes induce nuclear reprogramming of mouse and human has opened up new possibilities for cell replacement therapies. Although the combination of genes that induce pluripotency to some extenet, Oct4 and Sox2 appear to be a prerequisite. The introduction of four genes, several of which have been linked with cancer, using retroviral approaches is however unlikely to be suitable for future clinical applications.

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Showing Results 41 - 50 of 69
Scientific News
Scientists Discover Neurochemical Imbalance in Schizophrenia
Researchers discovers that neurons from schizophrenia patients secrete higher amounts of three neurotransmitters.
Building Replacement Kidneys in the Lab
Milestone reached in work to build replacement kidneys in the lab.
Diabetes Researchers Find Faster Way to Create Insulin-producing Cells
A new protocol can turn stem cells into reliable, insulin-producing cells in about six weeks.
Wiping the Slate Clean
Erasing cellular memory and resetting human stem cells.
Combining Antibodies, Iron Nanoparticles and Magnets Steers Stem Cells to Injured Organs
Study published in nature communications details targeted nanomedicine therapy to regenerate heart muscle injured by heart attack.
Turning Human Skin Cells Into Immune-Fighting White Blood Cells
The fast and safe technique developed at the Salk Institute circumvents problems that have hindered regenerative medicine.
Clinical Trial to Test Safety of Stem Cell-Derived Therapy for Type 1 Diabetes
UC San Diego is initial site for first-in-human testing of implanted cell therapy.
In Directing Stem Cells, Context Matters
The surface cells are grown on has a profound effect on differentiation.
Banked Blood Grows Stiffer With Age
It may look like fresh blood and flow like fresh blood, but the longer blood is stored, the less it can carry oxygen into the tiny microcapillaries of the body.
Rare Stem Cells in Testis that Hold Potential for Infertility Treatments Identified
Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells — and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests.
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