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The advancement of feeder-independent culture systems for undifferentiated human pluripotent stem cells towards greater regulatory compliance

Defined and feeder-independent cell culture systems provide a platform for greater reproducibility and standardization in human pluripotent stem cell (hPSC) research, mTeSR 1 has become the most widely cited feeder independent system for the culture of undifferentiated human ES and iPSC.

Omentum-derived stromal cells improve myocardial regeneration
Luigi Balducci1, Rocco De Siena1, Antonella Blasi1, Manuela Gessica Montanaro1, Marilisa Saldarelli1, Vittorio Saponaro2, Carmela Martino1, Gaetano Logrieco3,

Human ADSCs (Adipose derived stem cells) could represent an interesting therapy to apply in heart infarction and, more in general, in regenerative medicine. Furthermore, these cells have at least three advantages: good amounts of starting material, expansion feasibility and no ethical restrictions.

Homing of bone marrow derived mononuclears after intracoronary transventricular transplantation
Homing of bone marrow derived mononuclears after intracoronary transventricular transplantation

A new method of administration of bone marrow derived mononuclear cells (BMMCs) was studied using the model of acute myocardial infarction in rats. The transplanted cells were detected only in the scar tissue and had fibroblast-like phenotype. They differentiated neither into cardiomyocytes nor into the cells of blood vessels.

Clinical Evaluation of human embryonic stem cells (hESCs) induced with directed differentiation to gonadotrope cells to cure vasculogenic impotency and to improve coital frequency in males. An open st
Timothy S. Andersson, David K. Chin, Wendy Hiu Wai Wong

This work demonstrates the clinical efficacy, tolerability and safety of patient-syngenic hESC induced with directed differentiation to gonadotrope cells. Hypothalamus transmits gonadotropin releasing factor to pituitary that sets off LH and FSH to Sertoli cell and Seminiferous tubule resulting Leydig cell to produces testosterone. This potential offers a rationale to evaluate hESCs to cure patients with vasculogenic impotency and to improve coital frequency in males.

Clinical Evaluation of induced pluripotent stem cells (iPSc) to cure patients with Psoriasis Vulgaris. An Open Study.
Timothy S. Andersson, David K. Chin, Wendy H. Wong

To evaluate the clinical efficacy of iPSc directed to interfere T-cell activation to cure patients with psoriasis. Twenty subjects were enrolled. Each patient was administered iv with syngenic iPS. Those showing lower PASI score were considered cured. The study states that induced iPSCs are safe and impart significant clinical efficacy to cure patients with psoriasis.

Cell Therapy Product Manufacturing in a Hospital Setting
Richard C. Meagher, PhD1,2, Leo I. Gordon, MD1,2, Morris Kletzel, MD1,2,3, Seema Singhal, MD,1,2, Thomas Shook, MT (ASCP)2, Marcelo Villa MT (ASCP)2, Mehboob Merchant SLS (ASCP)2, Brian Stepien2, Jayesh Mehta, MD1,2

This presentation describes in detail the development and establishment of a current good manufacturing practices (cGMP) facility for the purpose of manufacturing cell and tissue products intended for human use in a hospital setting.

PRESENTATION OF A NEW SOURCE FOR TEETH TISSUE ENGINEERING
Fahimeh S. TABATABAEI, Jafar AI, Tahereh S .JAFARZADEH KASHI

Tooth regeneration is a biological technique to solving problems of tooth loss. The detection of various stem cells in unerupted tooth buds, dental pulp or bone marrow has provided opportunities for their management in dentin-pulp repair. However, these cells types are limited by: availability, invasiveness of extraction and in some cases limited proliferative capacity. Herein we hypothesized that endometrial adult stem cells could be induced into odontoblasts.

Correlation between the stem cells differentiation and topography of Zinc oxide nanorods
Newsha Kavosh, James Doonan, Joe Briscoe, Farahnaz Ansari, and Jeremy J. Ramsden

Since the conformation and symmetry may be equally important, we examine the order of nanorods on the surface to simulate the in vitro differentiation of stem cells and we revealed that stem cells respond differently to nanoscale features under the same conditions. Altering the orientation of nanotubular zinc oxide on the surface revealed changes in stem cell behaviour.

Mechanisms of beneficial effects of human placenta MSC transplantation in rats with experimental ischemic stroke
Yarygin K.N., Kholodenko I.V., Konieva A.A., Burunova V.V., Tairova R.T., Gubsky L.V., Cheglakov I.B., PirogovYu.A., Yarygin V.N., Skvortsova V.I.

Human MSC transplantation significantly reduced the volume of experimental ischemic lesion in rat model. It also greatly stimulated stem and progenitor cell proliferation in the subventricular region and hippocampus and cell migration from these areas towards the ischemia site. Beneficial effects of MSC in rats with brain ischemia are likely to be associated with enhancement of host neural stem and progenitor cell proliferation and migration towards the affected area.

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Scientific News
Mechanically Stimulating Stem Cells
MIT biological engineering graduate student Frances Liu is studying ways to alter mechanical properties of cell environments to produce desired chemical outputs.
Molecule Controls Stem Cell Plasticity By Boosting Gene Expression
Sox9 appears to lead the activation of super-enhancers that boost genes associated with stem cell plasticity.
Stem Cells Show Promise For Reversing Type 2 Diabetes
Scientists at the University of British Columbia and BetaLogics, have shown for the first time that Type 2 diabetes can be effectively treated with a combination of specially-cultured stem cells and conventional diabetes drugs.
A Single-Cell Breakthrough
UNC School of Medicine scientist Scott Magness and collaborators use their newly developed technology to dissect properties of single stem cells. The advancement will allow researchers to study gastrointestinal disorders and cancers like never before.
‘Mini-Lungs’ Grown To Aid The Study Of Cystic Fibrosis
'Mini-lungs’ have been created using stem cells derived from skin cells of patients with cystic fibrosis.
Brains or Skin?
Researchers identify a vital protein that can determine head and brain development.
Stem Cells Lurking In Tumors Can Resist Treatment
Researchers at Washington University School of Medicine in St. Louis are studying how cancer stem cells make tumors harder to kill and are looking for ways to eradicate these treatment-resistant cells.
Tetanus Shot Improves Patient Survival With Brain Tumor Immunotherapy
Study shows patient survival increased when the immune system was primed with a tetanus booster.
New Test Uses Human Stem Cells to Identify Dangerous Side Effects of Drugs
New test uses combinations of cells from a single donor's blood.
Promising Method To Treat Sickle Cell Disease
Stem cell gene therapy technique leads to production of healthy blood cells, could be used for other genetic diseases.
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