|Omentum-derived stromal cells improve myocardial regeneration|
Luigi Balducci1, Rocco De Siena1, Antonella Blasi1, Manuela Gessica Montanaro1, Marilisa Saldarelli1, Vittorio Saponaro2, Carmela Martino1, Gaetano Logrieco3,
Human ADSCs (Adipose derived stem cells) could represent an interesting therapy to apply in heart infarction and, more in general, in regenerative medicine. Furthermore, these cells have at least three advantages: good amounts of starting material, expansion feasibility and no ethical restrictions.
|Homing of bone marrow derived mononuclears after intracoronary transventricular transplantation|
Homing of bone marrow derived mononuclears after intracoronary transventricular transplantation
A new method of administration of bone marrow derived mononuclear cells (BMMCs) was studied using the model of acute myocardial infarction in rats. The transplanted cells were detected only in the scar tissue and had fibroblast-like phenotype. They differentiated neither into cardiomyocytes nor into the cells of blood vessels.
|Clinical Evaluation of human embryonic stem cells (hESCs) induced with directed differentiation to gonadotrope cells to cure vasculogenic impotency and to improve coital frequency in males. An open st|
Timothy S. Andersson, David K. Chin, Wendy Hiu Wai Wong
This work demonstrates the clinical efficacy, tolerability and safety of patient-syngenic hESC induced with directed differentiation to gonadotrope cells. Hypothalamus transmits gonadotropin releasing factor to pituitary that sets off LH and FSH to Sertoli cell and Seminiferous tubule resulting Leydig cell to produces testosterone. This potential offers a rationale to evaluate hESCs to cure patients with vasculogenic impotency and to improve coital frequency in males.
|Clinical Evaluation of induced pluripotent stem cells (iPSc) to cure patients with Psoriasis Vulgaris. An Open Study.|
Timothy S. Andersson, David K. Chin, Wendy H. Wong
To evaluate the clinical efficacy of iPSc directed to interfere T-cell activation to cure patients with psoriasis. Twenty subjects were enrolled. Each patient was administered iv with syngenic iPS. Those showing lower PASI score were considered cured. The study states that induced iPSCs are safe and impart significant clinical efficacy to cure patients with psoriasis.
|Cell Therapy Product Manufacturing in a Hospital Setting|
Richard C. Meagher, PhD1,2, Leo I. Gordon, MD1,2, Morris Kletzel, MD1,2,3, Seema Singhal, MD,1,2, Thomas Shook, MT (ASCP)2, Marcelo Villa MT (ASCP)2, Mehboob Merchant SLS (ASCP)2, Brian Stepien2, Jayesh Mehta, MD1,2
This presentation describes in detail the development and establishment of a current good manufacturing practices (cGMP) facility for the purpose of manufacturing cell and tissue products intended for human use in a hospital setting.
|PRESENTATION OF A NEW SOURCE FOR TEETH TISSUE ENGINEERING|
Fahimeh S. TABATABAEI, Jafar AI, Tahereh S .JAFARZADEH KASHI
Tooth regeneration is a biological technique to solving problems of tooth loss. The detection of various stem cells in unerupted tooth buds, dental pulp or bone marrow has provided opportunities for their management in dentin-pulp repair. However, these cells types are limited by: availability, invasiveness of extraction and in some cases limited proliferative capacity. Herein we hypothesized that endometrial adult stem cells could be induced into odontoblasts.
|Correlation between the stem cells differentiation and topography of Zinc oxide nanorods|
Newsha Kavosh, James Doonan, Joe Briscoe, Farahnaz Ansari, and Jeremy J. Ramsden
Since the conformation and symmetry may be equally important, we examine the order of nanorods on the surface to simulate the in vitro differentiation of stem cells and we revealed that stem cells respond differently to nanoscale features under the same conditions. Altering the orientation of nanotubular zinc oxide on the surface revealed changes in stem cell behaviour.
|Mechanisms of beneficial effects of human placenta MSC transplantation in rats with experimental ischemic stroke|
Yarygin K.N., Kholodenko I.V., Konieva A.A., Burunova V.V., Tairova R.T., Gubsky L.V., Cheglakov I.B., PirogovYu.A., Yarygin V.N., Skvortsova V.I.
Human MSC transplantation significantly reduced the volume of experimental ischemic lesion in rat model. It also greatly stimulated stem and progenitor cell proliferation in the subventricular region and hippocampus and cell migration from these areas towards the ischemia site. Beneficial effects of MSC in rats with brain ischemia are likely to be associated with enhancement of host neural stem and progenitor cell proliferation and migration towards the affected area.
|Superporous SIKVAV-modified PHEMA scaffold promotes stem cell adhesion|
V.Vanecek, S.Kubinova, D.Horak, V.Proks, E.Sykova
Poly(2-hydroxyethyl methacrylate) (PHEMA) is successfully used as a scaffold material for tissue engineering; however, it lacks functional groups that support cell adhesion. The laminin-derived peptide sequence SIKVAV is known to mimic the function of laminin, which is one of the biologically active proteins of the extracellular matrix. In this report, the adhesion of mesenchymal stem cells (MSC) to SIKVAV-modified PHEMA was investigated.