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DNA Microarrays for Microbiological Diagnosis in Stem Cell Cultures
F. Cobo, A. Nieto, P. Catalina, JL. Cortés, A. Barroso, C. Cabrera, R. Montes, A. Barnie and A. Concha

In stem cell cultures there is the possibility of infectious disease transmission to the recipients. Any microbial contamination of the donor`s biological products or introduced during the manufacturing process can potentially present a serious hazard to the recipients. The majority of potential contaminants are mycoplasma and other bacterias, yeasts and fungi. Moreover, viral and prion contamination of cell cultures and “feeder” cells is also a common risk.

In vitro Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Towards the Osteoblast Lineage. A Model to Study the Effects of Cancer Cells on Bone Formation
Hichame Id Boufker, Fabrice Journé, Laurence Lagneaux, Tatiana Tondreau and Jean-Jacques Body

This poster describes an in vitro model of DAG-induced osteogenic differentiation of bone marrow mesenchymal stem using various osteoblastic markers. Human MSC should constitute a useful in vitro tool to the effects of osteotropic cancer cells on osteoblast differentiation and to better understand the inhibition of normal formation during the process of tumor-induced osteolysis.

Microbiological Control in a Stem Cell Bank: Standardisation
F. Cobo, A. Nieto, R.M. Montes, C. Cadrera, A. Barnie, J.L.Cortes, P. Catalina, L. Gutierrez, R. Lopez and A. Concha

The transplant of cells of human origin is a sector of medicine which shows a high increase and which entails great opportunities for treatment of certain diseases. Stem cell banks should assure the quality, the traceability and the safety of cultures in order to avoid transmission of disease.

Mesenchymal Stem Cells: Coming of Age?
Alexandra Stolzing and Andy Scutt

The effects of aging on human mesenchymal stem cells, (MSC) were investigated. MSC were isolated from patients of different ages and the different parameters of aging were measured either immediately after isolation or after long-term cultivation in vitro. Markers of senescence were investigated, including p21, p53 and beta-galactosidase levels. Antioxidative defense capacity of the MSC were tested together with markers of oxidative damage and antioxidative enzyme activities.

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Showing Results 61 - 64 of 64
Scientific News
Program for Breakthrough Biomedical Research to Celebrate 15 Years
A program that fosters basic science projects of potentially high impact is celebrating 15 years of discovery at UC San Francisco.
UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice
Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
Team Successfully Converts Human Skin Cells into Embryonic Stem Cells
The breakthrough marks the first time human stem cells have been produced via nuclear transfer and follows several unsuccessful attempts by research groups worldwide.
Nobel Prize Rockets Stem Cell Program to New Heights
Shinya Yamanaka's Feat Brings fresh attention to promise of regeneration medicine.
Cobra Biologics and Vaccibody Sign Agreement to Manufacture DNA Vaccine
Companies announce agreement to manufacture Vaccibody’s lead DNA vaccine candidate against HPV-induced malignancies.
Stem Cells Show Promise for Treating Rare Nerve Disease
Scientists have used iPS cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia (A-T).
Two MIT Professors Named Howard Hughes Medical Institute Investigators
Peter Reddien and Aviv Regev are among 27 top biomedical scientists selected nationwide.
Cell Therapy Promise Highlighted at UCSF Symposium
Old-line pharmaceutical companies and maturing biotech businesses both are graybeards compared to newer ventures focused on cell therapy.
Researchers Chart Epigenomics of Stem Cells That Mimic Early Human Development
Collaborative study will help overcome hurdles to using stem cells to treat diseases and injuries.
NYSCF Scientists Create Personalized Bone Substitutes from Skin Cells
For treatment of large bone defects and traumatic injuries.
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