|Clinical Evaluation of induced pluripotent stem cells (iPSc) to cure patients with Psoriasis Vulgaris. An Open Study.|
Timothy S. Andersson, David K. Chin, Wendy H. Wong
To evaluate the clinical efficacy of iPSc directed to interfere T-cell activation to cure patients with psoriasis. Twenty subjects were enrolled. Each patient was administered iv with syngenic iPS. Those showing lower PASI score were considered cured. The study states that induced iPSCs are safe and impart significant clinical efficacy to cure patients with psoriasis.
|Cell Therapy Product Manufacturing in a Hospital Setting|
Richard C. Meagher, PhD1,2, Leo I. Gordon, MD1,2, Morris Kletzel, MD1,2,3, Seema Singhal, MD,1,2, Thomas Shook, MT (ASCP)2, Marcelo Villa MT (ASCP)2, Mehboob Merchant SLS (ASCP)2, Brian Stepien2, Jayesh Mehta, MD1,2
This presentation describes in detail the development and establishment of a current good manufacturing practices (cGMP) facility for the purpose of manufacturing cell and tissue products intended for human use in a hospital setting.
|PRESENTATION OF A NEW SOURCE FOR TEETH TISSUE ENGINEERING|
Fahimeh S. TABATABAEI, Jafar AI, Tahereh S .JAFARZADEH KASHI
Tooth regeneration is a biological technique to solving problems of tooth loss. The detection of various stem cells in unerupted tooth buds, dental pulp or bone marrow has provided opportunities for their management in dentin-pulp repair. However, these cells types are limited by: availability, invasiveness of extraction and in some cases limited proliferative capacity. Herein we hypothesized that endometrial adult stem cells could be induced into odontoblasts.
|Correlation between the stem cells differentiation and topography of Zinc oxide nanorods|
Newsha Kavosh, James Doonan, Joe Briscoe, Farahnaz Ansari, and Jeremy J. Ramsden
Since the conformation and symmetry may be equally important, we examine the order of nanorods on the surface to simulate the in vitro differentiation of stem cells and we revealed that stem cells respond differently to nanoscale features under the same conditions. Altering the orientation of nanotubular zinc oxide on the surface revealed changes in stem cell behaviour.
|Mechanisms of beneficial effects of human placenta MSC transplantation in rats with experimental ischemic stroke|
Yarygin K.N., Kholodenko I.V., Konieva A.A., Burunova V.V., Tairova R.T., Gubsky L.V., Cheglakov I.B., PirogovYu.A., Yarygin V.N., Skvortsova V.I.
Human MSC transplantation significantly reduced the volume of experimental ischemic lesion in rat model. It also greatly stimulated stem and progenitor cell proliferation in the subventricular region and hippocampus and cell migration from these areas towards the ischemia site. Beneficial effects of MSC in rats with brain ischemia are likely to be associated with enhancement of host neural stem and progenitor cell proliferation and migration towards the affected area.
|Superporous SIKVAV-modified PHEMA scaffold promotes stem cell adhesion|
V.Vanecek, S.Kubinova, D.Horak, V.Proks, E.Sykova
Poly(2-hydroxyethyl methacrylate) (PHEMA) is successfully used as a scaffold material for tissue engineering; however, it lacks functional groups that support cell adhesion. The laminin-derived peptide sequence SIKVAV is known to mimic the function of laminin, which is one of the biologically active proteins of the extracellular matrix. In this report, the adhesion of mesenchymal stem cells (MSC) to SIKVAV-modified PHEMA was investigated.
|The effect of different magnetic nanoparticle coatings on the efficiency of stem cell labeling|
M. Kapcalova, M. Babic, P. Jendelova, V. Herynek, K. Likavcanova, D. Horak, M. Hajek, E. Sykova
|Study of volumetric oxygen transfer coefficient in a Taylor vortex flow bioreactor|
Patricia Ap. Santiago; Claudio A Suazo; Roberto C Giordano.
In biochemical processes involving cultivation of animal cells, the supply of oxygen in culture medium is an extremely important parameter in the project of bioreactors and its operation. In this work, the global volumetric transfer coefficient of oxygen (KLa) is evaluated in a Taylor vortex flow bioreactor (TVFB) and a correlation of mass transfer, of this equipment, is proposed.
|Reliable and Predictive In Vitro Assays for Myelotoxicity and Cardiotoxicity of Kinase Inhibitors|
Clarke E (1), Schwengberg S (2), Kettenhofen R (2), Dos Santos G (1), Bohlen H (2)
Kinase inhibitors (KIs) represent a new class of rationally designed drugs. The success of Imatinib has prompted the development of other KIs for the treatment of various cancers and inflammation. Although more successful than conventional therapies, myelotoxicity and cardiotoxicity are often major side effects of KIs. In order to predict if newly developed molecules demonstrated significant myelotoxicity or cardiotoxicity, we assessed a number of TKIs using in vitro models.