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A Boost for Regenerative Medicine
Growing tissues and organs in the lab for transplantation into patients could become easier after scientists discovered an effective way to produce three-dimensional networks of blood vessels, vital for tissue survival yet a current stumbling block in regenerative medicine.
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Experimental method uses genetics-guided biomechanics, patient-specific stem cells.
Immune Cells Remember Their First Meal
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Bio-Mimicry Method For Preparing & Labeling Stem Cells Developed
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Transcription Factor Isoforms Implicated in Colon Diseases
UC Riverside study explains how distribution of two forms of a transcription factor in the colon influence risk of disease.
New Bio-Glass Could Make it Possible to Re-Grow or Replace Cartilage
Researchers at Imperial College London have developed a material that can mimic cartilage and potentially encourage it to re-grow.
Stem Cell Advance Could Be Key Step Toward Treating Deadly Blood Diseases
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Harnessing Engineered Slippery Surfaces For Tissue Repair
A new method could facilitate the transfer of intact regenerating cell sheets from the culture dish to damaged tissues in patients.
Brazilian Zika Virus Strain Causes Birth Defects in Experimental Models
First direct experimental proof of causal effect, researchers say.
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Pluripotent Stem Cells
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Pluripotent cells of the early embryo originate all types of somatic cells and germ cells of adult organism. Pluripotent stems cell lines were derived from mammalian embryos and adult tissues using different techniques and from different sources. Despite different origin, all pluripotent stem cell lines demonstrate considerable similarity of the major biological properties. This book examines the fundamental mechanisms which regulate normal development of pluripotent cells into different lineages and are disrupted in cancer initiating cells. Analysis gene expression profiles, differentiation potentials and cell cycle of normal and mutant pluripotent stem cells provide new data to search molecular targets to eliminate malignant cells in tumours. In this book, the authors also aim to present a global picture of how extracellular signals, intracellular signal transduction pathways and transcriptional networks co-operate together to determine the cell fate of pluripotent stem cells. Practical, ethical and legal considerations that must be addressed before induced pluripotent stem (iPS) cells can realise their potential in the treatment of degenerative disease is discussed as well. Recent advancements in the cancer stem cell hypothesis are also summarised and the challenges associated with targeting resistant cancers in the context of stem cell microenvironments are presented.

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