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Featured Products
Featured ProjectSirius inForm
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Featured ProjectXiril Liquid Handling Workstation Neon 100
Xiril Liquid Handling Workstation Neon 100

Webcasts
Worried about your cell-based assays? Remote monitoring with CNS offers complete peace of mind!Worried about your cell-based assays? Remote monitoring with CNS offers complete peace of mind!
Michael Fejtl, Market Manager, Tecan Austria
Biotransformation: Still a Bottleneck for in Vitro Kinetic and Dynamic ApproachesBiotransformation: Still a Bottleneck for in Vitro Kinetic and Dynamic Approaches
Sandra Coecke, European Centre for the Validation of Alternative Methods, speaking at ADME & Predictive Toxicology Europe

Market Reports
ADME/Tox Technologies
RI Technologies

This report on ADME/Tox Technologies gives a market insight into products and services used in the ADME/Tox industry. Predictive technologies analyzed include in vivo, in vitro, and in silico.
China Pharmaceutical Market Outlook
Global Data

The report details the macroeconomic environment of China, providing a background of the financial and demographic situations in the country, as well as identifying key demographics. It covers the pharmaceutical market broken down by market segment, and the popularity of biosimilars and biologics, identifying where the strongest market potentials lie.
Biomarkers in Drug Discovery - Integration in Early Stage Promotes Use of Companion Diagnostics to Optimize Therapeutic Outcomes
Global Data

The report describes the history of biomarkers and their role in fulfilling the unmet needs of the conventional drug discovery process. The drivers and barriers for the biomarkers market, along with the key issues faced in the application of biomarkers in the drug discovery process, are highlighted.
Pathways to Efficient Drug Development - Advances in Modeling and Simulation Outcomes to Fuel Pipeline Productivity
GBI Research

The report examines the reasons why the pharmaceutical industry is looking for improvements in efficiency whilst acknowledging that pharmaceutical R&D remains a long and risky process. It looks in detail at precompetitive research and evaluates how the industry is pulling together to research solutions to problems that are common to all companies.
Drug Discovery and Development Market in Asia
Global Data

The report provides key data, information and analysis of the major trends and issues affecting the drug discovery and development market in seven major countries in Asia, namely China, India, Russia, Japan, Singapore, Taiwan and South Korea.
Life Science Software 2013: Markets and Opportunities
Biopharm Reports

This reports into in the life science field examines the use of specialist software and databases relating to the conduct of PCR, DNA sequencing, DNA microarray, flow cytometry, mass spectrometry and disease biomarker studies. The studies were carried out to assist software developers and vendors to identify market opportunities in these fields.
Benchtop Automation Trends 2013
HTStec

This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Lab Instrument Rental Trends 2012
HTStec

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on lab instrument rental carried out in September 2012.
Emerging Pharmaceutical Markets 2012
Select Biosciences Ltd

The report covers all the key aspects of the various emerging pharmaceutical markets and has broadly outlined the factors that are affecting the industry. The report also provides current and predicted future performance of the pharmaceutical market in different regions of the world.
Preclinical Models: Innovative solutions to accelerate drug discovery and development
Business Insights

Preclinical models are developed to test lead compounds for toxicity and efficacy. They are valuable tools for minimizing development costs and reducing failures prior to the commencement of human trials. Problems with traditional animal models such as cost, ethics and suitability have prompted researchers to develop new models and systems to overcome these disadvantages.
Scientific News
Observing Behavior of Single Molecules in Real Time
New technique developed by Stanford scientists allows observation of single molecules of protein or DNA as they bind with other molecules.
Development and Validation of LC/MS/MS Method and its Application to a Pharmacokinetic Study
Researchers aimed to develop a LC/MS/MS method to monitor plasma levels of montelukast, gliclazide, and nifedipine for application in pharmacokinetic studies and routine clinical practice.
Mini-Livers Show Promise to Reduce Animal Use in Science
Using this method, cells from one mouse could be used to test 1000 drug compounds to treat liver disease, and reduce animal use by up to 50,000.
Advancing the Knowledge of Pharmaceutical Processes
Linkam Scientific Instruments report on the use of their stages in the study of pharmaceutical processes.
Gathering and Exploring Scientific Knowledge in Pharmacovigilance
The holistic assessment of widespread electronic medical records empowers valuable insights over adverse drug events.
A Silk Coat for Diamonds Makes Sleek New Imaging and Drug Delivery Tool
New kind of tiny glowing particle could provide a novel technique for biological imaging and drug delivery.
Biases in Animal Studies may Differ from those in Clinical Trials
New analysis of animal studies on cholesterol-lowering statins found that non-industry studies had results that favored the drugs even more than studies funded by industry.
TAP Biosystems Presents New Data on 3D Cell Culture Research
Discussing the application of RAFT 3D models in oncology, toxicology and neuroscience cell-based screening programmes.
Scripps' Scientists Develop Promising Drug Candidates for Pain and Addiction
Two new drug scaffolds offer researchers novel tools that act on the kappa opioid receptor.
World’s Tiniest Drug Cabinets could be Attached to Cancerous Cells for Long Term Treatment
Reservoirs of pharmaceuticals could be manufactured to bind specifically to infected tissue such as cancer cells for slow, concentrated delivery of drug treatments.
Business News
Scripps Research Institute Creates New Drug Discovery Initiative
Scripps Advance is a new drug discovery initiative to translate early-stage biomedical research projects into clinical development candidates.
4SC Discovery Receives €450K Epigenetic Research Grant
4SC Discovery GmbH will receive a EUR 450,000 grant from the EU for the research of new compounds targeting cardiovascular diseases such as stroke.
CyBio to be Merged into Analytik Jena
Analytik Jena AG is planning to merge the business of its subsidiary CyBio AG with its core business in the Life Science business unit.
Agilux Laboratories Appoints Head of GLP Bioanalysis
Dr LeLacheur appointed Head of GLP Bioanalysis for Agilux's pharmaceutical development services.
AstraZeneca, MRC Collaboration to Create New Centre for Early Drug Discovery
The Companies today announced the groundbreaking collaboration aimed at better understanding the mechanisms of human disease. The collaboration will see the creation of a joint research facility at AstraZeneca’s new R&D centre in Cambridge in the UK.
GSK, EMBL-EBI and Sanger Institute Launch Target Validation Initiative
Centre for Therapeutic Target Validation will utilise genomics and big data to drive drug discovery.
Adocia Confirms Positive Clinical Results for its BioChaperone® Combo
BioChaperone Combo is the first combination based on insulin glargine to show a fast and long action in type I diabetic patients.
4SC Discovery Collaborates with Heidelberg University Hospital
The two-year R&D project is aimed at delivering a lead compound that can be brought to clinical development with the help of potential partners.
CiToxLAB Appoints John C. Kapeghian as Senior Director of Toxicology
This appointment makes the Montreal site attractive to North American clients and boosts CiToxLAB’s expertise in preclinical development and regulatory affairs.
Purdue, Houston Methodist to Take Drug Discoveries from the Bench Top to the Bedside
The planned collaboration on research and educational initiatives includes clinical trials of drugs developed at Purdue.

Events
Controlled & Modified Drug Rel
07 May 2014
Controlled & Modified Drug Rel ...
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Evolution Summit 2014
07 May 2014
Evolution Summit 2014 ...
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4th Traceability & The Drug Qu
15 May 2014
4th Traceability & The Drug Qu ...
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Clinical Diagnostics & Researc
28 May 2014
Clinical Diagnostics & Researc ...
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ePosters
Isolation, Identification, and Determination of Designer Anabolic Steroids Commonly Found in Dietary Supplements
U.S. Food and Drug Administration, Forensic Chemistry Center

A general analytical approach in identifying emerging steroid-like compounds is presented, including analysis by GC-MS, LC-MS, and/or HPLC-UV. Isolation of unknown compounds was achieved by high performance liquid chromatography with fraction collection. Isolated compounds were characterized by Nuclear Magnetic Resonance spectroscopy and high resolution accurate mass-mass spectrometry to elucidate their structure.
Combining low and high volume liquid handling capabilities for ADME screening
TTP Labtech, Tecan Group, F.Hoffman-La Roche Ltd

In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.
Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model
Wurzburg University

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.
Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS
Denator AB

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.
Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS
Denator AB

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.
Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model
Wurzburg University

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.
Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles
University of Karachi

MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.
Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison
International Islamic University Malaysia

Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.
Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
ReachBio LLC

This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.
Digital Dispensing for Direct Dilution: New Flexibility in Dose-Response Analyses
Tecan Group

In addition to the economic advantages of improving speed, precision, compound usage and waste, digital dispensing offers scientific advantages. This includes making the execution of complicated experiments easy and fast.
Application Notes
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Tecan AC Extraction Plate™
Tecan Group Ltd.

THC , the main active compound in marijuana, is metabolized to ?9-(11-OH)-tetrahydrocannabinol (11-OH-THC) and 11-nor-?9-carboxy-tetrahydrocannabinol (THC-COOH). Tecan’s AC Extraction Plate with TICE technology enables a straightforward workflow that is reproducible and cost efficient. Liquid chromatography coupled with tandem mass spectrometry (LC-MSMS) provides an easy and cost-effective means for fast, sensitive and precise analysis of THC and its metabolites.
Creating dose-response curves for cell-based and biochemical assays with the HP D300 Digital Dispenser
Tecan Group Ltd.

Small molecule drug discovery relies on the evaluation of one compound against another compound. Measurement of the activity of the small molecule against a target must be standardized by determining the IC50 or EC50 value using does response curve. The classical method of generating a dose-response curve is via serial dilution; however this approach has a number of drawbacks. Today, there is an alternative solution which eliminates these limitations: the HP D300 Digital Dispenser.
3D cell culture: a realistic and reproducible collagen-based environment
Tecan Group

Researchers are increasingly turning to 3D cell culture techniques, due to the improved physiological relevance of the cellular environment. 3D cell cultures offer a more in vivo-like response to stimuli more closely resembling the behavior of animal models or the human body.
Optimized cell culture
Tecan Group Ltd.

Culturing of various stable cell lines, including bacterial, yeast, hybridoma, insect and mammalian lines, and stem cells, is an important task in the pharmaceutical industry. The cells need to be maintained and expanded for use in cell-based assays, such as siRNA screening, ADME and high content screening, as well as for clone selection.
Improved cell viability assay performance using PrestoBlue® Reagent
Tecan Trading AG

Cell proliferation and viability assays are widely used in academic and life science laboratories, and are becoming increasingly common in the pharmaceutical industry. Assessment of cellular viability markers in cell-based applications is mandatory for laboratories working with in vitro systems.
Rapid Critical Micelle Concentration (CMC) Determination Using Fluorescence Polarization
BioTek Instruments

The determination of the critical micelle concentration (CMC) value of surfactants under different environmental conditions is important for a number of different biological and chemical processes. Because the CMC is not a constant value, shifting with different environmental conditions, it is important that a rapid, reliable and easy methodology be available to facilitate testing.
Analysis of a New High Throughput Screening Detection Technology for Rapid hERG Safety Testing using a Fluorescence Polarization Assay
Biotek Instruments

Support Synergy™ Neo launch by providing speed and sensitivity data for Fluorescence Polarization detection mode in low volume 384-well plate using hERG biochemical assay as a Model.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton

Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
Fully Automated 24-Well Madin-Darby Canine Kidney (MDCK) Permeability Assay Utilizing the Hamilton Microlab® Star Liquid Handling Platform
Hamilton

We have successfully developed a fully automated protocol utilizing a Hamilton MICROLAB STAR integrated with select third party peripheral devices to suit the assay requirements. The method was validated using 23 marketed drugs with diverse physico-chemical properties and a wide range of published apparent permeabilities (Papp).
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