Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Plexpress Launches Dedicated Canine ADME-Tox Service

Published: Friday, July 05, 2013
Last Updated: Friday, July 05, 2013
Bookmark and Share
TRACPACK DOG INDUCTION for preclinical drug candidate screening.

Plexpress has launched a specific ADME-Tox service for canine preclinical drug candidate screening, in collaboration with Admescope.

The new TRACPACK DOG INDUCTION screening service provides canine cytochrome P450 (CYP) mRNA analysis using primary dog hepatocytes followed by CYP enzyme activity measurements.

Hepatocytes from three separate donors are used, generating CYP mRNA expression and protein activity data produced in line with the FDA recommendations for human hepatocytes.

Reliable canine-specific CYP analysis is important in order to improve predictions for human pharmaceutical development.

The validated Dog ADME-Tox mRNA panel from Plexpress includes all relevant CYP targets and reference genes, ready-to-analyze in a single well for high throughput multiplexing.

Additional genes can also be included according to study needs.

The combination of high sample throughput with gene multiplexing increases assay speed while minimizing technical variation, making TRAC highly cost- and time-efficient, boosting efficiency in CRO and Pharma laboratories.

In addition to mRNA analysis, TRACKPACK DOG INDUCTION also offers subsequent CYP activity measurements thanks to Plexpress’ collaboration with Admescope.

To investigate metabolites, study compounds are exposed for 72h, after which substrates for CYP-specific model reactions are added, and the samples analyzed.

TRACPACK DOG INDUCTION provides a single, integrated service for all canine CYP induction analysis, ensuring consistent and reliable data.

All TRACPACK results are delivered electronically, in an easy-to-use, summarized report for quick and easy data analysis.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Plexpress Announces ADME-Tox Programs for CRO’s
EMA and FDA recommend mRNA testing in ADME-Tox studies for superior sensitivity.
Friday, May 03, 2013
Plexpress and Admescope Expand TRACPACK ADME-Tox Screening Services
Efficient, accurate drug discovery that works alongside FDA recommendations.
Monday, November 05, 2012
Plexpress Announces Collaboration with Admescope
CRO to offer TRAC gene expression analysis for pre-clinical ADME-Tox studies.
Thursday, May 17, 2012
Plexpress and SBW Partner to Offer TRAC Gene Expression Analysis
CRO adds TRAC to service portfolio for pre-clinical ADME-Tox studies.
Tuesday, May 08, 2012
Plexpress Secures $2.3M to Commercialize TRAC High-Content Gene Expression Analysis Platform
Company targets applications including companion diagnostics and ADMET.
Thursday, April 19, 2012
Scientific News
Development in Preventing Macular Degeneration
Following macular degeneration insight, promising drugs to prevent vision loss have been identified.
Improving Tumour Therapy with Nanoparticles
UHN nanoparticle called PEARLs is a promising utilisation of photo-thermal therapy for cancer treatment.
New Antidepressant Treatment Discovered
Scientists have demonstrated how gene therapy could lead to new treatments for depression.
Cellular Origin of Skin Cancer Identified
Scientists have identified ‘cell of origin’ in the most common form of skin cancer, and followed the process that leads to tumour growth.
Enhancing Drug Safety with a Web-Based Data Tool
Online and open-access tool allows anyone to find, combine and analyse FDA drug information.
Genetic Missing Link Could Explain Mystery of Heritability
Mother’s diet during pregnancy can permanently affect offspring attributes through process that could be strongly influenced by genetic variation in an unexpected part of the genome.
Does the Transport of Next-Gen Vaccines Lie with E.coli?
Study shows harmless E.coli capsule could aid next-gen vaccine delivery and efficiency.
Breathing in a Cure
Researchers working on inhalable ibuprofen to treat cystic fibrosis.
Complex Mouse Behaviours Linked to the Genes that Influence Them
Two novel genes were associated with methamphetamine sensitivity and anxiety-like behavior.
One Giant Leap for the Future of Safe Drug Delivery
Sheffield engineers make major breakthrough in developing silk ‘micro-rockets’ that can be used safely in biological environments.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!