Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>Products>This Product

SoPRano™: High Throughput and Sensitive Label-free Screening on a Plate Reader

Product Description

SoPRano™ is unique in enabling label-free SPR screening in solution using a standard absorbance plate reader, delivering rapid, cost effective, label-free assays for a broad range of applications:

•    Small molecule screening (including fragment screening);
•    Antibody screening and characterisation;
•    ADME and physico-chemical property determination.

particle+image.jpgSoPRano works by using specifically functionalized gold nanoparticles in solution (e.g. coated with a target receptor or antibody) which exhibit Localized Surface Plasmon Resonance (LSPR), a variant of the proven SPR phenomenon. With LSPR, plasmons remain localized on individual nanoparticles and induce an absorbance band in the visible spectrum that shifts with the refractive index of the medium.  This shift is readily quantifiable, such that when ligands interact with the functionalized nanoparticles they cause a reproducible absorbance change in the visible spectrum. As a result, SoPRano technology enables label-free screening on a standard absorbance plate reader.

SoPRano has many advantages that make it ideal for compound, fragment and antibody screening, as well as for high throughput ADME applications:

•    Solution-based ‘mix-and-read’ assays
•    96- and 384-well compatible
•    High sensitivity
•    Reproducible
•    Potential for high throughput
•    Requires only standard lab equipment – no expensive SPR instrument required!
•    Cost effective

In summary, SoPRano™ is a label-free, high throughput and highly flexible early drug discovery technology, that is broadly enabling, cost effective and requires no capital investment.

Build-your-own assay kits
SoPRano ‘build-your-own’ assay kits for small molecule and antibody applications are available, based upon a versatile and easy to use charge adsorption conjugation process:

•    CA-1 and CA-2 charge adsorption kits are available in 20, 100 and 500 ml sizes.

Additional coupling technologies are currently being developed.

The kits include colloidal gold nanoparticles and detailed protocols for conjugation and assay development, enabling you to couple your protein target or antibody and perform screens in your own labs. Kits are available in various sizes, from Starter Kits for preliminary assay development, through to large volume kits for higher throughput applications.

ADME and physico-chemical property kits
ADME and physic-chemical property kits are available for:
•    Human Serum Albumin (HSA)
•    Alpha-1-acid Glycoprotein (AGP)
•    HSA and AGP combination kit, with calculation of Fraction Unbound (Fu)
•    pKa
•    Redox Potential
•    Bioavailablity
•    Blood-Brain-Barrier

The ready to use ADME kits include pre-conjugated gold nanoparticles and detailed protocols.

Contract research services
Our highly experienced team also provides bespoke services for:
•    Assay development;
•    Screening;
•    ADME/physico-chemical assays

Product SoPRano™: High Throughput and Sensitive Label-free Screening on a Plate Reader
Company Pharma Diagnostics
Price Request a quote
More Information View company product page
Catalog Number Unspecified
Quantity Unspecified
Company Logo

Pharma Diagnostics
I&I Center Brussels Z.1 Researchpark 310 1731 Zellik Belgium


Scientific News
Salford Lung Study - The First Real World Clinical Trial
In this podcast, we learn about the Salford Lung Study and its potential to revolutionize the way we assess new drugs and treatments around the world.
Study Finds Key Regulator in Pulmonary Fibrosis
Researchers identify an enzyme that could open the way to therpies for chronic fatal lung disease.
Signaling Pathway Could Be Key to Improved Osteoporosis Treatment
Inhibition of SIK2 enzyme both stimulates bone formation and reduces bone breakdown in animal model.
Ovarian Cancer Insight
Study showed tumours release cytokines to attract macrophages, which secrete growth factors that in turn promote tumour growth.
Substance Can Potentially Postpone Aging
Researchers bridge the gap between two main aging theories - repairs to the DNA and poor functioning mitochondria.
Untangling Cause Of Memory Loss In Neurodegenerative Diseases
NIH-funded mouse study identifies a possible therapeutic target for a family of disorders.
New Model for Understanding Human Myeloma
Researchers develop mouse model where mice carry six human genes involved in human tumour growth.
Preventing Alzheimer's in Mice
Researchers have prevented the Alzheimer’s development in mice by using a virus delivery system to transport a specific gene into the brain.
New Platform for Roundworms Could Speed Up Drug Delivery
Researchers have developed a large-scale in vitro drug discovery platform that could speed up scientific research.
Scientists Speed Up Muscle Repair
Researchers discovered genetically modified mice were able to support far more regenerative stem cells, for muscle repair, than previously thought.


SELECTBIO Market Reports
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,200+ scientific videos