Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>Products>This Product
  Products


High Content Toxicology: CellCiphr® Premier

Product Image
Product Description
Hepatotoxicity is one of the main reasons for drug withdrawals, accounting for 37% of all therapeutics taken off the market between 1994 and 2006.

CellCiphr® Premier combines an extended panel of toxicologically-relevant endpoints with Cyprotex’s CellCiphr® classifier to provide one of the most reliable clinical hepatotoxicity predictors available (sensitivity = 70% and specificity = 100%).

Both HepG2 (replicating cells) and primary rat hepatocytes (metabolically competent cells) are investigated at multiple time points (extending from 4 hrs to 5 days to identify early and late stage toxic effects).

The data can be integrated with actual or predicted Cmax to correct for exposure-related effects.

The extended panel of end points allows CellCiphr® Premier to offer enhanced predictivity for hepatotoxicity risk over the standard CellCiphr® panels.
Product High Content Toxicology: CellCiphr® Premier
Company Cyprotex
Price Request a quote
More Information View company product page
Catalog Number Unspecified
Quantity Unspecified
Company Logo

Cyprotex
15 Beech Lane, Macclesfield, Cheshire SK10 2DR United Kingdom

Tel: +44 (0)1625 505100



Scientific News
Retractable Protein Nanoneedles
The ability to control the transfer of molecules through cellular membranes is an important function in synthetic biology; a new study from researchers at Harvard’s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells.
Iron in the Blood Could Cause Cell Damage
Concentrations of iron similar to those delivered through standard treatments can trigger DNA damage within 10 minutes, when given to cells in the laboratory.
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
Insights into the Function of the Main Class of Drug Targets
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.
Honey’s Potential to Save Lives
The healing powers of honey have been known for thousands of years.
Muscles on-a-Chip
This study may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Envigo Rat Models Proven to be Susceptible to Intra-Vaginal HSV-2 Infection and Protectable
Scientific findings establish the effectiveness of new approach to investigate the protective effects of vaccine candidates and anti-viral microbodies and to study asymptomatic primary genital HSV-2 infection.
Valvena, GSK Sign New R&D Collaboration
Valneva to supply process development services for EB66® -based Influenza vaccines.
Food Triggers Creation of Regulatory T Cells
IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.

SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!