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The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Vitamin A May Help Improve Pancreatic Cancer Chemotherapy
The addition of high doses of a form of vitamin A could help make chemotherapy more successful in treating pancreatic cancer, according to an early study by Queen Mary University of London (QMUL).
Breakthrough Approach to Breast Cancer Treatment
Scripps scientists have designed a drug candidate that decreases growth of breast cancer cells.
Non-Toxic Approach to Treating Variety of Cancers
A team of researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine recently discovered a novel, non-toxic approach to treating a wide variety of cancers.
Making Injectable Medicine Safer
Researchers remove excess additives from drugs, which could reduce the odds of serious allergic reactions and other side effects.
An Old-New Weapon Against Emerging Chikungunya Virus
Researchers utilize existing drugs to interfere with host factors required for replication of Chikungunya virus.
Brazilian Zika Virus Strain Causes Birth Defects in Experimental Models
First direct experimental proof of causal effect, researchers say.
'Kidney on a Chip' Facilitates Safer Drug Dosing
University of Michigan researchers have used a "kidney on a chip" device to mimic the flow of medication through human kidneys and measure its effect on kidney cells.
Ketamine Metabolism Lifts Depression
NIH-funded team finds rapid-acting, non-addicting agent in mouse study.

Preclinical Models: Innovative solutions to accelerate drug discovery and development
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Introduction

Preclinical models are developed to test lead compounds for toxicity and efficacy. They are valuable tools for minimizing development costs and reducing failures prior to the commencement of human trials. Problems with traditional animal models such as cost, ethics and suitability have prompted researchers to develop new models and systems to overcome these disadvantages.

Scope of this research

  • Assessment of current developments in preclinical ADMET research for drug discovery and development.
  • Evaluation of the drivers behind innovation in preclinical research.
  • Details of current trends in ADMET research and how technology companies are developing models to improve and accelerate discovery and development.
  • Analysis of the in-vivo, in-vitro, in-silico and systems biology models that are advancing toxicity prediction in early drug discovery.
  • Key recommendations for industry players relating to the development of preclinical models to accelerate productivity and increase knowledge.

Research and analysis highlights

Established preclinical models correlate poorly with human in-vivo biological responses, and innovation is therefore needed to approximate human responses more accurately.

In-vivo, in-vitro and in-silico models are becoming increasingly more sophisticated, and a push for integration is creating demand for highly efficient centralized platforms to expedite predictive ADMET insight.

Pharmaceutical companies need more innovative preclinical solutions to advance drug discovery efforts, and in-silico biosimulation has the potential to transform the discovery and development process.

Key reasons to purchase this research

  • Understand the basis of ADMET testing and why it is a necessary and important component of preclinical research.
  • Evaluate the key recent developments and activities of companies who are developing and licensing new ADMET technologies.
  • Identify existing models and discover how new ones are being developed to improve productivity and knowledge.
  • Assess the technologies and systems that are driving drug discovery and development.
  • Examine action points and considerations for technology providers and pharmaceutical companies looking to accelerate preclinical research.



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