Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home
  
Scientific News
Keeping Tumor Growth at Bay
Engineers at Washington University in St. Louis found a way to keep a cancerous tumor from growing by using nanoparticles of the main ingredient in common antacid tablets.
Cancer Cells Kill Off Healthy Neighbours
Cancer cells create space to grow by killing off surrounding healthy cells, according to UK researchers working with fruit flies.
Future of Medicine Could be Found in a Tiny Crystal Ball
A Drexel University materials scientist has discovered a way to grow a crystal ball in a lab. Not the kind that soothsayers use to predict the future, but a microscopic version that could be used to encapsulate medication in a way that would allow it to deliver its curative payload more effectively inside the body.
Bile Acid Supports Production of Blood Stem Cells
A research group at Lund University has been able to show that bile acid is transferred from the mother to the foetus via the placenta to enable the foetus to produce blood stem cells.
Chemical Used to Replace BPA is Potentially Toxic
This study is the first to examine the effects of BPA and BPS on brain cells and genes that control the growth and function of organs involved in reproduction.
A Better Model for Parkinson's
Scientists at EPFL solve a longstanding problem with modeling Parkinson’s disease in animals. Using newfound insights, they improve both cell and animal models for the disease, which can propel research and drug development.
Improving Delivery of Poorly Soluble Drugs Using Nanoparticles
A technology that could forever change the delivery of drugs is undergoing evaluation by the Technology Evaluation Consortium™ (TEC). Developed by researchers at Northeastern University, the technology is capable of creating nanoparticle structures that could deliver drugs into the bloodstream orally – despite the fact that they are normally poorly soluble.
Toxicity Testing With Cultured Liver Cells
Microreactor replaces animal testing.
Neural Networks Adapt to the Presence of a Toxic HIV Protein
HIV-associated neurocognitive disorders (HAND) afflict approximately half of HIV infected patients.
Faster Drug Discovery?
Startup develops more cost-effective test for assessing how cells respond to chemicals.

Preclinical Models: Innovative solutions to accelerate drug discovery and development
Bookmark and Share

Introduction

Preclinical models are developed to test lead compounds for toxicity and efficacy. They are valuable tools for minimizing development costs and reducing failures prior to the commencement of human trials. Problems with traditional animal models such as cost, ethics and suitability have prompted researchers to develop new models and systems to overcome these disadvantages.

Scope of this research

  • Assessment of current developments in preclinical ADMET research for drug discovery and development.
  • Evaluation of the drivers behind innovation in preclinical research.
  • Details of current trends in ADMET research and how technology companies are developing models to improve and accelerate discovery and development.
  • Analysis of the in-vivo, in-vitro, in-silico and systems biology models that are advancing toxicity prediction in early drug discovery.
  • Key recommendations for industry players relating to the development of preclinical models to accelerate productivity and increase knowledge.

Research and analysis highlights

Established preclinical models correlate poorly with human in-vivo biological responses, and innovation is therefore needed to approximate human responses more accurately.

In-vivo, in-vitro and in-silico models are becoming increasingly more sophisticated, and a push for integration is creating demand for highly efficient centralized platforms to expedite predictive ADMET insight.

Pharmaceutical companies need more innovative preclinical solutions to advance drug discovery efforts, and in-silico biosimulation has the potential to transform the discovery and development process.

Key reasons to purchase this research

  • Understand the basis of ADMET testing and why it is a necessary and important component of preclinical research.
  • Evaluate the key recent developments and activities of companies who are developing and licensing new ADMET technologies.
  • Identify existing models and discover how new ones are being developed to improve productivity and knowledge.
  • Assess the technologies and systems that are driving drug discovery and development.
  • Examine action points and considerations for technology providers and pharmaceutical companies looking to accelerate preclinical research.



SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!