Tuesday, May 22, 2012
Technology Networks
Technology Networks
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 | Wither Biobanking for Cancer? Building our Reserves or, a Spending Spree? Malcolm Mason, Director of the Wales Cancer Bank, speaking at World Biobanking Summit 2011. |
 | Actionable Biomarkers for Rheumatoid Arthritis Dr William Robinson, Stanford University, speaking at Microarray World Congress 2011. |
Competitor Analysis: Anti-Obesity Peptides and Biologics
La Merie
The report provides a competitor evaluation in the field of R&D projects with anti-obesity peptides and biologics as of February 2012. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. The database also contains information about discontinued projects.
Cryopreservation Equipments in Stem Cells - A Global Market Watch, 2009-2015
Axis Research Mind
The report reviews the latest trends in cryopreservation equipments used in stem cells technology with a perceptive to disclose the near-future growth prospects in cryopreservation of stem cells.
3D Cell Culture Trends
HTStec
This market report summarizes the results of HTStec’s second industry-wide global web-based benchmarking survey on three dimensional (3D) cell culture carried out in October 2011.
Preclinical Development of Monoclonal Antibodies and Related Biologicals: Emerging technologies and new therapeutic candidates
Business Insights
This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others. More than 80 popular and emerging technologies are named, explained and illustrated with original full-color diagrams.
Global Biosimilars (Follow-on biologics) Market: An Analysis
Koncept Analytics
The report covers the overview, market size and segmentation of the biosimilars market. The various drivers and the challenges faced by the market are also discussed in detail. The competitive aspect of the market is also highlighted and the key players are profiled with their strategies for this market.
Cell-Based Assays For Biologics Trends 2011
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on cell-based assays for biologics carried out in July 2011.
Umbilical Cord Blood Banking Market Trends 2011
Select Biosciences Ltd
This report focuses upon cord blood banking and provided quantitative market analysis of the space as it relates to the growth of the field, utilization trends of cord blood for different diseases in different countries of the world.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights
This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Biostorage Trends 2010
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on biological sample storage carried out in July 2010. The objectives of the study were to comprehensively document current practices and preferences in biological sample storage and to understand future user requirements.
Cancer Vaccines & Circulating Tumor Cells (CTCs) 2011 Report
Select Biosciences Ltd
This market report from Select Biosciences presents a comprehensive industry analysis of the cancer vaccines space as well as that of the emerging circulating tumor cells (CTCs) space. These two areas are evolving and expanding driven by the greater emphasis on personalized medicine especially in the cancer/oncology space.
La Merie
The report provides a competitor evaluation in the field of R&D projects with anti-obesity peptides and biologics as of February 2012. Purchase of the downloadable pdf report includes a 6-month online access to the data of the report and any updates since the publication date. The database also contains information about discontinued projects.
Cryopreservation Equipments in Stem Cells - A Global Market Watch, 2009-2015
Axis Research Mind
The report reviews the latest trends in cryopreservation equipments used in stem cells technology with a perceptive to disclose the near-future growth prospects in cryopreservation of stem cells.
3D Cell Culture Trends
HTStec
This market report summarizes the results of HTStec’s second industry-wide global web-based benchmarking survey on three dimensional (3D) cell culture carried out in October 2011.
Preclinical Development of Monoclonal Antibodies and Related Biologicals: Emerging technologies and new therapeutic candidates
Business Insights
This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others. More than 80 popular and emerging technologies are named, explained and illustrated with original full-color diagrams.
Global Biosimilars (Follow-on biologics) Market: An Analysis
Koncept Analytics
The report covers the overview, market size and segmentation of the biosimilars market. The various drivers and the challenges faced by the market are also discussed in detail. The competitive aspect of the market is also highlighted and the key players are profiled with their strategies for this market.
Cell-Based Assays For Biologics Trends 2011
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on cell-based assays for biologics carried out in July 2011.
Umbilical Cord Blood Banking Market Trends 2011
Select Biosciences Ltd
This report focuses upon cord blood banking and provided quantitative market analysis of the space as it relates to the growth of the field, utilization trends of cord blood for different diseases in different countries of the world.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights
This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Biostorage Trends 2010
HTStec
This market report summarizes the results of HTStec’s global web-based benchmarking survey on biological sample storage carried out in July 2010. The objectives of the study were to comprehensively document current practices and preferences in biological sample storage and to understand future user requirements.
Cancer Vaccines & Circulating Tumor Cells (CTCs) 2011 Report
Select Biosciences Ltd
This market report from Select Biosciences presents a comprehensive industry analysis of the cancer vaccines space as well as that of the emerging circulating tumor cells (CTCs) space. These two areas are evolving and expanding driven by the greater emphasis on personalized medicine especially in the cancer/oncology space.
Model Requirements for Biobank Software Systems
The overview shows that the guideline successfully incorporates the best practices of international standards on biobanks, giving users a single and consistent document to review.
Mucosis Announces Positive Proof-Of-Concept Data for Mimopath® Platform in Humans
Mimopath®-based vaccines are able to produce balanced immune responses in both circulating blood and the respiratory tract.
Prosonix Demonstrates Improved Delivery and Co-localization of Respiratory Medicines
New review published in European Respiratory Disease(ERD).
Mucosis Announces Publication of Preclinical Data of Novel Influenza Vaccines
Mucosally administered Mimopath-based influenza vaccine protects against both homologous and heterologous challenge.
Insights into MRSA Epidemic
Scientists identify a gene playing a pivotal role in epidemic waves of MRSA infections in Asia.
Possible Clues Found to why HIV Vaccine Showed Modest Protection
Analysis by NIH-supported scientists may help identify requirements for HIV vaccine.
HPV Vaccine May Help Women With Cervical Conditions
Healthcare article reports how study suggests immunization can reduce their risk for cervical disease later on.
J. Craig Venter, Ph.D., Describes Biofuels, Vaccines and Foods from Made-to-Order Microbes
Scientists are using decades of knowledge garnered from sequencing or “reading” the genetic codes of thousands of living things to now start writing new volumes in the library of life.
‘Universal’ Vaccines could Finally Allow for Wide-Scale Flu Prevention
An emerging class of long-lasting flu vaccines could do more than just save people the trouble of an annual flu shot.
Analysis of Host-Cell Proteins in Biotherapeutic Proteins by Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry
This paper presents assays for identification and quantification of host-cell proteins in biotherapeutic proteins over 5 orders of magnitude in concentration.
The overview shows that the guideline successfully incorporates the best practices of international standards on biobanks, giving users a single and consistent document to review.
Mucosis Announces Positive Proof-Of-Concept Data for Mimopath® Platform in Humans
Mimopath®-based vaccines are able to produce balanced immune responses in both circulating blood and the respiratory tract.
Prosonix Demonstrates Improved Delivery and Co-localization of Respiratory Medicines
New review published in European Respiratory Disease(ERD).
Mucosis Announces Publication of Preclinical Data of Novel Influenza Vaccines
Mucosally administered Mimopath-based influenza vaccine protects against both homologous and heterologous challenge.
Insights into MRSA Epidemic
Scientists identify a gene playing a pivotal role in epidemic waves of MRSA infections in Asia.
Possible Clues Found to why HIV Vaccine Showed Modest Protection
Analysis by NIH-supported scientists may help identify requirements for HIV vaccine.
HPV Vaccine May Help Women With Cervical Conditions
Healthcare article reports how study suggests immunization can reduce their risk for cervical disease later on.
J. Craig Venter, Ph.D., Describes Biofuels, Vaccines and Foods from Made-to-Order Microbes
Scientists are using decades of knowledge garnered from sequencing or “reading” the genetic codes of thousands of living things to now start writing new volumes in the library of life.
‘Universal’ Vaccines could Finally Allow for Wide-Scale Flu Prevention
An emerging class of long-lasting flu vaccines could do more than just save people the trouble of an annual flu shot.
Analysis of Host-Cell Proteins in Biotherapeutic Proteins by Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry
This paper presents assays for identification and quantification of host-cell proteins in biotherapeutic proteins over 5 orders of magnitude in concentration.
Spectral Diagnostics to Present at BioFinance 2012
Conference to be held at the St. Andrew's Club & Conference Centre in Toronto, Ontario.
TTP Labtech will Showcase its Latest Automated Technology Innovations in Europe
Delivering a wealth of new products to the attendees of ELA 2012.
USPTO Grants Codexis Patent for Enzymes Used in Hep-C Therapeutics
Highlights how Codexis platform enables breakthrough biocatalytic processes.
Partnership Provides Processing and Scale-up for AAV Vectors
Avalanche Biotechnologies, Inc. and Lonza announce global manufacturing collaborate for adeno-associated viral vectors for gene therapy.
European Life Science Awards Nominees Announced
The awards ceremony celebrates the very best of the industry’s achievements and precedes the Second European Lab Automation (ELA) conference and exhibition taking place from 30th- 31st May at the Congress Centre Hamburg.
GE Healthcare Life Sciences Completes Acquisition of Xcellerex, Inc.
Acquisition expands GE Healthcare’s offering of technologies and services for the manufacture of recombinant proteins, antibodies and vaccines.
Intercell Completes Equity Private Placement of EUR 15.2 Million at a Price of EUR 2.30 Per New Share
Bringing total volume of combined debt and equity financing to EUR 35.2 million.
Frost & Sullivan gives an overview of the Global Automated Biobanking market
Robotics to aid and drive long term vision of truly personalised medicine
Shengquan and Novozymes in partnership to commercialize cellulosic ethanol
The Chinese Shengquan Group will start commercial production of cellulosic ethanol for solvents and biochemicals in June 2012 utilizing enabling technology from Novozymes
Service & Production Co-ordinator Appointed by Hi-Line Industries
Appointment of Mr Mark Baily as a service & production co-ordinator.
Conference to be held at the St. Andrew's Club & Conference Centre in Toronto, Ontario.
TTP Labtech will Showcase its Latest Automated Technology Innovations in Europe
Delivering a wealth of new products to the attendees of ELA 2012.
USPTO Grants Codexis Patent for Enzymes Used in Hep-C Therapeutics
Highlights how Codexis platform enables breakthrough biocatalytic processes.
Partnership Provides Processing and Scale-up for AAV Vectors
Avalanche Biotechnologies, Inc. and Lonza announce global manufacturing collaborate for adeno-associated viral vectors for gene therapy.
European Life Science Awards Nominees Announced
The awards ceremony celebrates the very best of the industry’s achievements and precedes the Second European Lab Automation (ELA) conference and exhibition taking place from 30th- 31st May at the Congress Centre Hamburg.
GE Healthcare Life Sciences Completes Acquisition of Xcellerex, Inc.
Acquisition expands GE Healthcare’s offering of technologies and services for the manufacture of recombinant proteins, antibodies and vaccines.
Intercell Completes Equity Private Placement of EUR 15.2 Million at a Price of EUR 2.30 Per New Share
Bringing total volume of combined debt and equity financing to EUR 35.2 million.
Frost & Sullivan gives an overview of the Global Automated Biobanking market
Robotics to aid and drive long term vision of truly personalised medicine
Shengquan and Novozymes in partnership to commercialize cellulosic ethanol
The Chinese Shengquan Group will start commercial production of cellulosic ethanol for solvents and biochemicals in June 2012 utilizing enabling technology from Novozymes
Service & Production Co-ordinator Appointed by Hi-Line Industries
Appointment of Mr Mark Baily as a service & production co-ordinator.
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Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments
Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
Biopharmaceuticals Hiding in the Woods
University of New Brunswick
Suggestions are provided of how efficient industrial bioprocessing can be accomplished, independently of highly expensive molecular biology approaches, in order to recover natural products of medicinal value from wild plant species.
Expansion of mesenchymal stem cells from frozen UCB
StemCare A/S and Bioneer A/S
Umbilical cord blood (UCB) has recently been the focus of clinical applications. UCB contains of hematopoietic stem cells and mesenchymal stem cells (MSC). Clinical studies shows that MSC can be used in regenerative medicine hereby treatment of cardiac diseases. The aim of this project is to establish a protocol for isolation of MSCs from frozen UCB. This study demonstrated that it’s possible to expand MSC.
A Mix-and-Read Cell-Based Assay for Antibody Screening Against Epidermal Growth Factor Receptor
TTP Labtech Ltd
The conventional antibody screening assay based on antibody-antigen binding has been enzyme-linked immunosorbent assay (ELISA). While tedious and consuming, ELISA has proved sufficient for the identification of antibodies directed against secreted antigens. However, cell surface antigens (e.g. GPCRs) provide challenges for ELISA due to the shortage of soluble antigens and high variability resulting from loss of cells during wash procedures.
Facing the challenges in bio-pharmaceutical production: newly developed polymer-based ion exchange chromatography media and their application to the purification for Immunoglobulin – from egg yolk
YMC
Much attention has been given to ion exchange (IEX) media as a means to improve productivity as a result of increasing demand for higher efficiency on the downstream process. Until recently, strain optimisation for high productivity and upstream purification were the bottlenecks for most bio-processes.
Development and NDA-Level Validation of a Real-Time PCR Procedure for Detection and Quantification of Residual E.coli DNA Contamination of Biopharmaceutical Products
Aptuit, Inc.
Escherichia coli (E. coli) has been commonly used for the production of biopharmaceuticals. Among the impurities that must be monitored in biopharmaceuticals is residual host-cell DNA (HCD). This study describes the development and subsequent NDA-level validation of a real time PCR procedure developed in response to a client’s need to improve the sensitivity of detection and quantification of residual E. coli HCD in their drug product.
Gene Expression Profiling of Archived FFPE Samples
Miltenyi Biotech
According to the BBMRI (Biobanking and Biomolecular Resources Research Infrastructure) about 8,000,000 formalin-fixed paraffin-embedded (FFPE) samples derived from a multitude of different diseases have been collected in medical centers and biobanks all over Europe during the last decades.
BioTek Instruments
Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments
Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences
Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
Biopharmaceuticals Hiding in the Woods
University of New Brunswick
Suggestions are provided of how efficient industrial bioprocessing can be accomplished, independently of highly expensive molecular biology approaches, in order to recover natural products of medicinal value from wild plant species.
Expansion of mesenchymal stem cells from frozen UCB
StemCare A/S and Bioneer A/S
Umbilical cord blood (UCB) has recently been the focus of clinical applications. UCB contains of hematopoietic stem cells and mesenchymal stem cells (MSC). Clinical studies shows that MSC can be used in regenerative medicine hereby treatment of cardiac diseases. The aim of this project is to establish a protocol for isolation of MSCs from frozen UCB. This study demonstrated that it’s possible to expand MSC.
A Mix-and-Read Cell-Based Assay for Antibody Screening Against Epidermal Growth Factor Receptor
TTP Labtech Ltd
The conventional antibody screening assay based on antibody-antigen binding has been enzyme-linked immunosorbent assay (ELISA). While tedious and consuming, ELISA has proved sufficient for the identification of antibodies directed against secreted antigens. However, cell surface antigens (e.g. GPCRs) provide challenges for ELISA due to the shortage of soluble antigens and high variability resulting from loss of cells during wash procedures.
Facing the challenges in bio-pharmaceutical production: newly developed polymer-based ion exchange chromatography media and their application to the purification for Immunoglobulin – from egg yolk
YMC
Much attention has been given to ion exchange (IEX) media as a means to improve productivity as a result of increasing demand for higher efficiency on the downstream process. Until recently, strain optimisation for high productivity and upstream purification were the bottlenecks for most bio-processes.
Development and NDA-Level Validation of a Real-Time PCR Procedure for Detection and Quantification of Residual E.coli DNA Contamination of Biopharmaceutical Products
Aptuit, Inc.
Escherichia coli (E. coli) has been commonly used for the production of biopharmaceuticals. Among the impurities that must be monitored in biopharmaceuticals is residual host-cell DNA (HCD). This study describes the development and subsequent NDA-level validation of a real time PCR procedure developed in response to a client’s need to improve the sensitivity of detection and quantification of residual E. coli HCD in their drug product.
Gene Expression Profiling of Archived FFPE Samples
Miltenyi Biotech
According to the BBMRI (Biobanking and Biomolecular Resources Research Infrastructure) about 8,000,000 formalin-fixed paraffin-embedded (FFPE) samples derived from a multitude of different diseases have been collected in medical centers and biobanks all over Europe during the last decades.
Contaminant bovine IgG assay
Molecular Devices
Fetal calf serum containing bovine IgG is commonly used in mammalian cell culture media for the production of recombinant pharmaceuticals. During the purification process of a recombinant pharmaceutical, bovine IgG may be copurified with the product, and may represent a biological hazard for clinical use. Therefore, it may be necessary to assay for contaminant bovine IgG in a final product originating from mammalian cells.
LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Thermo Fisher Scientific
LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
Sample Reformatting and Sample Archiving
FluidX
Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
FluidX
With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.
Integrated Solutions for High-Throughput Bioprocessing Applications
Thermo Fisher Scientific
Advances in blood banking, industrial biotechnology, bio-production and pharmaceutical laboratories have driven the need to process multiple sample batches.
Molecular Devices
Fetal calf serum containing bovine IgG is commonly used in mammalian cell culture media for the production of recombinant pharmaceuticals. During the purification process of a recombinant pharmaceutical, bovine IgG may be copurified with the product, and may represent a biological hazard for clinical use. Therefore, it may be necessary to assay for contaminant bovine IgG in a final product originating from mammalian cells.
LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Thermo Fisher Scientific
LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
Sample Reformatting and Sample Archiving
FluidX
Biobanking is becoming a central element in the study of patient genetic data and clinical application of genetic research. Until recently, collections of DNA samples have tended to be fairly small and localized with varied sample containers that were unsuitable for an increasing throughput and automated system use.
Reading Racked 2D-Coded Cryo Tubes directly from -80ºC Freezer
FluidX
With the storage of biological samples such as DNA, protein, blood fractions and viable cells becoming commonplace. The need to store them at lower temperatures has resulted in reading challenges for traditional rack readers.
Integrated Solutions for High-Throughput Bioprocessing Applications
Thermo Fisher Scientific
Advances in blood banking, industrial biotechnology, bio-production and pharmaceutical laboratories have driven the need to process multiple sample batches.
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