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ADC Synthesis in Flow...
Behind the Science, ep. 12: My Samples A...Get Smart with Protein Digestion...Increase volume throughput from samples ...

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Webcasts
The Tip of the Iceberg - How Pipette Tips Influence Assay ResultsThe Tip of the Iceberg - How Pipette Tips Influence Assay Results
n this webinar, you will learn everything you need to know about pipette tips and the huge impact they can have on your results.
Pipette calibration - DonPipette calibration - Don't risk your results!
In this educational webinar, you will learn why the calibration of liquid handling instruments is important, how calibration is performed in a professional service center and which instruments should be calibrated on a regular basis.

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Pharmaceutical Key Trends 2011: Biosimilar Market Overview
Datamonitor plc

Biosimilars were estimated to have generated approximately $200m in sales during the twelve months to March 2010. Going forward, with branded biologics worth $55bn set to face patent expiry between 2011 and 2015, this presents a major opportunity for companies looking to enter the biosimilars market.
Preclinical Development of Monoclonal Antibodies and Related Biologicals: Emerging technologies and new therapeutic candidates
Business Insights

This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others. More than 80 popular and emerging technologies are named, explained and illustrated with original full-color diagrams.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights

This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Cancer Vaccines & Circulating Tumor Cells (CTCs) 2011 Report
Select Biosciences Ltd

This market report from Select Biosciences presents a comprehensive industry analysis of the cancer vaccines space as well as that of the emerging circulating tumor cells (CTCs) space. These two areas are evolving and expanding driven by the greater emphasis on personalized medicine especially in the cancer/oncology space.
Biosimilars and Biobetters: Positioning for a New Market
Select Biosciences Ltd

As regulatory frameworks for biosimilars development begin to take shape worldwide, there are growing opportunities for generics companies to enter the biologics market, a segment which is uniquely driven by unmet needs, commands premium prices, and continues to outperform the global pharma market.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Scientific News
Making It Personal
Cancer vaccine linked to increased immune response against leukemia cells.
Improved Stability, Shelf Life of Protein Drugs
Study improves protein drug stability and extend their shelf life by tested a novel route for non-covalent protein modification.
More Effective Strategy for Producing Flu Vaccines
Researchers have developed a virus backbone, allowing producers to grow vaccine viruses in mammalian cells, rather than in eggs.
Improving Drug Production with Computer Model
A model has been developed that can be used to improve and accelerate the production of biotherapeutics, cancer drugs, and vaccines.
First New HIV Vaccine Study for Seven Years Begins
South Africa hosts historic clinical trial of experimental HIV vaccine aiming to safely prevent HIV infection.
Vaccination Against UTIs
Researchers have successfully vaccinated mice against E.coli growth in the bladder and kidneys.
First Steps to Neutralising Zika
Researchers have discovered a highly potent antibody that neutralises Zika infection at a cellular level.
Human Astrovirus Structure Could Lead to Therapies, Vaccines
Study shows where neutralizing antibody binds to human astrovirus, a leading cause of viral diarrhoea in children, elderly, and the immune-compromised.
Fighting Off HIV Infection Closer to Reality
Researchers have made significant progress in the development of a potential vaccine to protect against HIV infection.
Powerful New Tools to Combat Zika
Researchers have created a way to replicate the stucture of Zika virus, removing the genes that make the virus infectious.
Business News
Synpromics, Sartorius Stedim Cellca Partner
The collaboration is set to develop an improved biologicals manufacturing process using synthetic promoters.
Novasep Pushes Further into Japanese Biopharma Market
Stronger local representation in growing Japanese biopharma market will improve Novasep’s capacity to equip and service Japanese clients.
GE Healthcare Expands Single-Use Manufacturing Capabilities
The expanded site will manufacture a range of single-use products, including cell growth bags, based on a newly developed film platform resulting from GE’s strategic alliance with Sealed Air.
Avacta Appoints Cancer Stem Cell Expert to Scientific Advisory Board
Professor Gerard Evan brings world leading expertise to the Affimer immuno-oncology therapeutics programme.
Cancer Research UK, TYG Oncology Partner
Cancer Research UK and CRT have signed an agreement with TYG oncology to take its new cancer vaccine TYG100 into clinical trials.
Eppendorf Acquires Calibration Technology
Acquisition will allow Eppendorf to expand it's service presence into Ireland.
CASSS, Biophysics Working Group Partner Up
Collaboration aims to bring scientists together from across public and private sectors to address challenges in biologics research and development.
Plasticell Completes £1.32 Million Financing to Advance Therapeutic Projects
Plasticell announces the completion of a two-part equity financing round, raising a total of £1.32 million from its shareholders and new investors.
FDA Accepts Novartis NDA for Ribociclib
Novartis LEE011 (ribociclib) granted FDA Priority Review for first-line treatment of HR+/HER2- advanced breast cancer.
BioStorage Technologies Accelerates Global Sample Management Service Expansion
Expands sample storage services in the U.S. and bioprocessing capabilities in China.

Events
2nd Good Laboratory Practice C
26 Jan 2017
2nd Good Laboratory Practice C ...
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2nd Annual Biomarker Conferenc
06 Feb 2017
2nd Annual Biomarker Conferenc ...
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European KOL/External Expert E
07 Feb 2017
European KOL/External Expert E ...
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Cell Culture & Downstream Worl
21 Feb 2017
Cell Culture & Downstream Worl ...
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ePosters
Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice
1. School of Pharmacy and Pharmaceutical Sciences, 2. School of Psychology Cardiff University, Cardiff, UK

The work presented in this poster aims to assess whether intracerebroventricular (ICV) administration of 2B3 alleviated age dependent memory deficits in PDAPP mice and to determine whether 2B3 altered APP metabolism and NMDA receptor phosphorylation ex vivo.
Multiplexed Cell- and Bead-based Assays in a No-wash Format for Biologics Screening and Characterization
TTP Labtech Inc, One Kendall Square, Suite B2303, Cambridge MA 02139-1594, USA

Here we present the results generated from multiplexed no-wash protocols using TTP Labtech’s mirrorball, a laser scanning cytometer.
Development of a Homogenous RSV Neutralization Assay on the Mirrorball Fluorescence Cytometer: A Simple, Safe and Robust Approach for High-throughput Screening
TTP Labtech Ltd, Melbourn Science Park, Melbourn, Royston, Hertfordshire, SG86EE, UK.

Here we present the development and implementation of a simple RSV-neutralization assay on TTP Labtech’s mirrorball fluorescence cytometer.
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
Quantitative Cell-Based Bioassays for Individual and Combination Immune Checkpoint Immunotherapy Targets
Promega Corporation

Immune checkpoint receptors are promising new immunotherapy
targets for the treatment of a variety of diseases including cancer and
autoimmune-mediated disorders. We developed a suite of cell-based
bioluminescent reporter bioassays for individual and combination
immune checkpoint immunotherapy targets including: PD-1 (PD-L1 or PD-L2), CTLA-4, LAG-3, TIGIT, PD-1+TIGIT, GITR, 4-1BB, CD40, and OX40.

Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis
Institute of high performance Computing, Astar

Recognising the key challenges, we develop an end-to-end computational framework for HCA dubbed “Deep Phenotyping” that perform unsupervised analysis to leverage on the data richness for the discovery of unknown sub-phenotypes with minimal labeling cost.
Translational Research of oral Neural Crest-Derived Stem Cells (oNCSCs) in Regenerative Dentistry
1Stavropol State Medical University, Russian Federation, 2Praxisteam Hasslinghausen, Germany, 3Implantology Center Kassel, Germany, 4Witten/ Herdecke University, Germany, 5University of Reading, UK, 6

In this review poster, we summarize current knowledge on the oral neural crest-derived stem cell populations (oNCSCs) and discuss their potential in regenerative periodontology as a part of regenerative dentistry.
Better Cell-Based Assays for Anti-CTLA-4, Anti-PD-1/PD-L1, and Bispecific Immunotherapy Drug Studies
Promega Corporation

Here we report the development of a panel of robust reporter assays to measure the potencies for biologics in immunotherapy. These assays reflect mode of action and can serve as valuable tools in immunotherapy drug development and discovery.
Development of a Robust Reporter-based T cell Activation Assay for Therapeutic Biologics in Immunotherapy
Promega Corporation

Jurkat T-cells stably expressing luciferase reporter driven by IL2 promoter or NFAT-RE, are used as effector cells. Tumor cell lines endogenously expressing cancer antigen are used as antigen presenting cells (APC). By co-cultivating the two cell lines in the presence of CD3 bispecific antibody, TCR/CD3 is activated in Jurkat effector cells. Luciferase activity is up regulated through IL-2 promoter or NFAT-RE activation.
Reporter Bioassays to Assess Therapeutic Antibodies for Immunotherapy Programs
Promega Corporation

Immunotherapy, also called biologic therapy or biotherapy, stimulates certain parts of the immune system to fight diseases such as cancer. Important drug targets in immunotherapy include: Co-inhibitory receptors, such as PD-1/PD-L1, CTLA-4, LAG3, Tim3; and co-stimulatory receptors, such as GITR, CD40, OX40, 4-1BB.
Current approaches to assaying these targets are cumbersome and variable. Here we offer an improved in vitro bioassay approach.
Application Notes
Integrating Automation and DOE to Streamline and Accelerate Quality by Design Activities for Process Chemistry
Unchained Labs

Unchained Labs' tools translate complex experiments into executable methods.
Preformulation and Stability Studies of Biotherapeutics Using DSC
Malvern Instruments Limited

The Malvern MicroCal VP-Capillary DSC has been used for rapid screening of buffers in preformulation development and for the optimization of storage conditions of antibodies during process development. The results correspond well with those obtained by other more time-consuming methods.
Accelerating Biotherapeutic Process Development Using Differential Scanning Calorimetry
Malvern Instruments Limited

This document illustrates how the technique can be used to examine the stability of individual domains in multi-domain proteins and guide process development for antibodies and other proteins.
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Malvern Instruments Limited

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
Identification of Insulin Oligomeric States Using SEC-MALS
Wyatt Technology Corporation

This application note shows how the combination of column chromatography (SEC/GPC) with MALS, DLS and RI detection can be applied as a powerful tool to identify monomers, dimers, hexamers and higher aggregates of insulin.
Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Wyatt Technology Corporation

Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.
The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability
Wyatt Technology Corporation

This experiment demonstrates that thermal and colloidal stability of proteins, two indicators of propensity to aggregate, as well as actual aggregation states, are all determined simultaneously during the screening process with dynamic light scattering (DLS) tools in order to rank the effectiveness of candidates and formulation conditions.
Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Malvern Instruments Limited

DSC data is useful in predicting the stability of a protein in solution. The Tm indicates thermostability, and Tm determination in different formulations is an approximate measure of the susceptibility to aggregation and other irreversible changes at lower temperatures.
Differentiation and characterization of subvisible particulates in therapeutic protein products
Malvern Instruments Limited

The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity.
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